Neat reaction technology for the synthesis of 4-oxo-thiazolidines derived from 2-SH-benzothiazole and antimicrobial screening of some synthesized 4-thiazolidinones

Abstract

The synthesis of 4-thiazolidinones 4a-j in a good yields from the heterocyclization reaction of 2-(benzothiazol-2-ylthio)-N'-benzylideneacetohydrazide 3a-j with SHCH 2 COOH in DMF in the presence of a catalytic amount of anhydrous ZnCl 2 under microwave irradiation is described and compared with conventional synthesis methods. All structures of the newly synthesized compounds were elucidated by elemental analysis and spectral data. Some of the new compounds were tested against bacteria (Gram-ve and Gram+ ve) and fungi.

Biological Activities of 2-Mercaptobenzothiazole Derivatives: A Review

“…The synthesized compounds were screened for their in vitro antimicrobial activities [88]. Screening results revealed significant inhibitory activity (inhibition zone 20–25 mm) of derivatives having a 2-OCH 3 -C 6 H 4 group at second position of the thiazolidine ring against Escherichia coli , Candida albicans, and Candida parapsilosis , whereas derivatives bearing 4-NO 2 -C 6 H 4 , 2-OH-C 6 H 4 , 4-OH-C 6 H 4 , 4-OCH 3 -C 6 H 4 , 2-Cl-C 6 H 4, and 4-Cl-C 6 H 4 groups were found to have moderate activity (inhibition zone 15–20 mm) against Bacillus subtilis , Staphylococcus aureus, and Escherichia coli .…”

Synthesis and spectroscopy studies of new neodymium(III) complexes with cyanamide derivatives as N-Donor ligand

“…The C=N stretching bands of phen in [Nd(phen) 2 Cl 3 .OH 2 ] underwent a modification when cyanamide ligands coordinated to the metal. The absorption bands at 1514, 1421 cm -1 (C=N of phen) shifted to lower waves upon complexation with cyanamide groups [12,22].…”

Synthesis, Characterization and Antimicrobial Activity of 1,2‐dihydroquinoxaline‐3‐yl‐3‐Substitutedphenyl‐1H‐pyrazole‐4‐Carbaldehyde

“…Among them, five membered heterocyclic compounds occupy a unique place in the realm of natural and synthetic organic chemistry. A few small heterocyclic molecules are known as pharmacophores as there are a number of biologically active and medicinally useful molecules . Electron‐rich nitrogen heterocycles play an important role in diverse biological activities.…”