Near‐visible light and <scp>UV</scp> photoprotection in the treatment of melasma: a double‐blind randomized trial

Castanedo-Cázares, Juan Pablo; Hernández-Blanco, Diana; Carlos-Ortega, Blanca; Fuentes-Ahumada, Cornelia; Torres-Álvarez, Bertha

doi:10.1111/phpp.12086

Cited by 91 publications

(78 citation statements)

References 21 publications

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“…Table shows the composition (INCI name) and the percentage added of each component to the formulation as well as the respective color index (CI) of the pigments. The pigments present in the formulation under study are iron oxides, which are used as visible light‐absorbing pigments in broad‐spectrum sunscreens . The color index (CI) classification is a system that promotes a universally accepted nomenclature for dyes and pigments that describes which numbers the exact color tone used as well as its chemical structure and properties …”

Section: Methodsmentioning

confidence: 99%

Influence of visible light on cutaneous hyperchromias: Clinical efficacy of broad‐spectrum sunscreens

Martini

Campos

2018

Photoderm Photoimm Photomed

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Section: Methodsmentioning

confidence: 99%

Influence of visible light on cutaneous hyperchromias: Clinical efficacy of broad‐spectrum sunscreens

Martini

Campos

2018

Photoderm Photoimm Photomed

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“…25 More recently, visible light (VL) has been implicated in development of melasma, especially in those with skin of colour. 28 Thus, for difficult to treat cases, the application of sunscreen, especially opaque ironoxide-containing sunscreens, should be considered. 26 Opaque sunscreens (e.g.…”

Section: Photoprotectionmentioning

confidence: 99%

Melasma: clinical diagnosis and management options

2015

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“…This may explain recurrence of melasma. 30 Therefore, further studies regarding the inflammatory profile in relation to onset, chronicity, use of bleaching agents, and exposure to different ranges of radiation are desirable, as this information may allow for preventive and therapeutic strategies for this disorder.…”

Section: Discussionmentioning

confidence: 99%

CD4, IL-17, and COX-2 Are Associated With Subclinical Inflammation in Malar Melasma

Rodríguez-Arámbula

Torres-Álvarez

Cortés-García

et al. 2015

The American Journal of Dermatopathology

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The pathogenesis of melasma, a common, photo-induced hyperpigmentary disorder, is not clearly understood. Significant factors linked to melasma are ultraviolet radiation exposure and genetic predisposition. Histological analysis has demonstrated that melasma is caused by a network of cellular interactions among melanocytes, keratinocytes, mast cells, fibroblasts, and dermal vasculature exhibits, features similar to chronic sun damage. Dermal inflammation caused by ultraviolet radiation might play an important role in the hyperpigmentation and reactivation of melasma lesions through the production of melanogenic cytokines and growth factors. Because the role of inflammation in this disorder is unknown, we used histochemistry, immunohistochemistry, and quantitative real-time polymerase chain reaction to evaluate melasma lesions from healthy female patients (n = 20) with malar melasma. Lesional skin without specific solar exposure or photoprotection measures within the previous 4 weeks was compared with nonlesional skin. The increased lymphocytic infiltrate in lesional skin was mainly composed of CD4 T cells, mast cells, and macrophages. Levels of the cytokine interleukin (IL)-17 and the proinflammatory mediator cyclooxygenase (COX)-2 were significantly elevated in affected skin compared with healthy skin. In addition, the Melasma Activity and Severity Index score, fraction of solar elastosis, and epidermal melanin were positively associated with COX-2 expression. There was no statistically significant difference in IL-1α, IL-1β, R-IL1, IL-6, IL-8, vascular endothelial growth factor, and tumor necrosis factor alpha expression levels. Together, these data indicated that melasma under unchallenged conditions is characterized by chronic inflammatory cells and mediators, which may explain its recurrent nature.

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Near‐visible light and UV photoprotection in the treatment of melasma: a double‐blind randomized trial

Abstract: UV-VL sunscreen enhances the depigmenting efficacy of hydroquinone compared with UV-only sunscreen in treatment of melasma. These findings suggest a role for VL in melasma pathogenesis.

Cited by 91 publications

References 21 publications

Influence of visible light on cutaneous hyperchromias: Clinical efficacy of broad‐spectrum sunscreens

Influence of visible light on cutaneous hyperchromias: Clinical efficacy of broad‐spectrum sunscreens

Melasma: clinical diagnosis and management options

CD4, IL-17, and COX-2 Are Associated With Subclinical Inflammation in Malar Melasma

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