Near real time confocal microscopy of amelanotic tissue: detection of dysplasia in ex-vivo cervical tissue

Collier, Tom; Lacy, Alicia; Malpica, Anaís; Follen, Michelle; Richards‐Kortum, Rebecca

doi:10.1109/iembs.2002.1106235

Cited by 45 publications

(74 citation statements)

References 19 publications

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“…5). 39 These trials further support the enormous potential of this new technology. Their results demonstrated that confocal imaging had a sensitivity of 89% and a specificity of 91%, which both were significantly better than those for colposcopy (a sensitivity of 85%, and a specificity of 69%).…”

Section: Reflectance Confocal Microscopymentioning

confidence: 86%

Optical imaging of the cervix

Drezek

Richards‐Kortum

Brewer

et al. 2003

Cancer

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Section: Reflectance Confocal Microscopymentioning

confidence: 86%

Optical imaging of the cervix

Drezek

Richards‐Kortum

Brewer

et al. 2003

Cancer

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“…Parameters extracted from confocal images were used to discriminate high-grade cervical pre-cancers with a sensitivity of 100% and a specificity of 91% in a study of 25 samples (Collier et al 2002). In vivo CRM has already been applied to oral mucosa.…”

Section: Confocal Reflectance Microscopymentioning

confidence: 99%

Non-Invasive Techniques for Detection and Diagnosis of Oral Potentially Malignant Disorders

Liu

Zhao

Zeng

et al. 2016

Tohoku J. Exp. Med.

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Oral squamous cell carcinoma (OSCC) is the most common oral and maxillofacial malignancy, and its morbidity and mortality rates are still high in most countries. Oral potentially malignant disorders (PMDs) are used to refer to a heterogeneous group of conditions that are characterized by increased risk for malignant transformation to OSCC. Currently identified oral PMDs include leukoplakia, erythroplakia, palatal lesions associated with reverse smoking, oral lichen planus, oral submucous fibrosis, actinic keratosis, and discoid lupus erythematosus. The early detection and diagnosis of these lesions are important for cancer prevention and disease management. In recent years, there has been a growing and persistent demand for new non-invasive, practical diagnostic techniques that might facilitate the early detection of oral PMDs. The non-invasive detection techniques evaluated in this review are divided into four categories: vital staining with a solution that can be used as a mouth rinse or applied onto a suspected area of the mouth, light-based detection systems, optical diagnostic technologies that employ returned optical signals to reflect structural and morphological changes within tissues, and salivary biomarkers. Most of these techniques have shown great potential for screening and monitoring oral PMDs. In this review article, the authors critically assess these non-invasive detection techniques for oral PMDs. We also provide a summary of the sensitivity and specificity of each technique in detecting oral PMDs and oral cancer, as well as their advantages, disadvantages, clinical applications, and indications.

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“…By moving the focal plane, different layers of the tissue are displayed. The imaging depth is up to 0.5 mm and allows identification of many intra-epithelial lesions (Collier et al, 2002;Rajadhyaksha et al, 1995;White et al, 1999). With special software, it is possible to 3D-reconstruct the volume scans in vivo.…”

Section: Introductionmentioning

confidence: 99%

“…The potentially high impact of RCE is due to several unique properties and recent technical developments: 1. Imaging depths of 0.2 -0.5 mm allow reliable identification of many intra-epithelial lesions (Collier et al, 2002;Rajadhyaksha et al, 1995;White et al, 1999). 2.…”

Section: Introductionmentioning

confidence: 99%