Optical imaging of the cervix

Drezek, Rebekah A.; Richards‐Kortum, Rebecca; Brewer, Molly; Feld, Michael S.; Pitris, Costas; Ferenczy, Alex; Faupel, Mark L.; Follen, Michele

doi:10.1002/cncr.11678

Cited by 86 publications

(59 citation statements)

References 39 publications

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“…47 Other reports of the most recent research in cervical cancer have also combined scattering spectroscopy with fluorescence. 48 Richards-Kortum's group has investigated the application of reflectance spectroscopy to other gynecological cancers. In an exploratory study of ovarian cancer in 18 patients, Utzinger et al were able to retrospectively separate ovarian cancers from normal ovary and benign neoplasms with a sensitivity of 86% and specificity of 80%.…”

Section: © 2 0 0 4 L a N D E S B I O S C I E N C E D O N O T D I S mentioning

confidence: 99%

Spectrroscopic Sensing of Cancer and Cancer Therapy: Current Status of Translational Research

Bigio

Bown²

2004

Cancer Biology & Therapy

143

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Various types of optical spectroscopy have been investigated as methods to effect a non-invasive, real-time in-situ assessment of tissue pathology. All of these methods have one basic principle in common: the optical spectrum of a tissue contains information about the biochemical composition and/or the structure of the tissue, and that information conveys diagnostic information. The biochemical information can be obtained by measuring absorption, fluorescence, or Raman scattering signals. Structural and morphological information may be obtained by techniques that assess the elastic-scattering properties of tissue. These basic approaches are useful for the detection of cancer as well as for other diagnostic applications such as hemoglobin saturation, intra-luminal detection of atherosclerosis, and simply the identification of different tissue types during procedures. Optical spectroscopic measurements can also be employed in the management of disease treatment. The site-specific pharmacokinetics of chemotherapy and photodynamic therapy agents can be used to customize dosage to the patient, and diagnostic spectroscopy can be used to monitor response to treatment. In recent years clinical studies have provided indications of potential efficacy, and some of these modalities are now entering a translational research stage, with an eye to approval and commercialization. A benefit of these methods is their inherent low cost and ease of implementation, generally mediated with small portable instruments, not requiring any specialized facilities, and eventually not requiring expert interpretation. This paper reviews briefly the most common methods of diagnostic optical spectroscopy, and reviews in greater depth recent clinical translational research invoking scattering spectroscopy as the enabling technology, which has been the experience of the authors.

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Section: © 2 0 0 4 L a N D E S B I O S C I E N C E D O N O T D I S mentioning

confidence: 99%

Spectrroscopic Sensing of Cancer and Cancer Therapy: Current Status of Translational Research

Bigio

Bown²

2004

Cancer Biology & Therapy

143

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“…Peak emission intensities from collagen, NADH and FAD are typically seen at emission wavelengths of 390, 450 and 550 nm, respectively. LIF has been studied in multiple pathologies, 27 including gynecologic applications such as human cervical neoplasia, [26][27][28][29][30][31] human ovarian malignancies 16,32 and primate models for ovarian cancer chemopreventative studies. 33,34 Both OCT and LIF have shown promise in ovarian cancer diagnostics independently.…”

Section: Resultsmentioning

confidence: 99%

Simultaneous optical coherence tomography and laser induced fluorescence imaging in rat model of ovarian carcinogenesis

Hariri

Liebmann

Marion

et al. 2010

Cancer Biology & Therapy

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pathologic changes in the ovary, specifically the characterization of precursor lesions to malignant transformation.The incidence of all types of ovarian cancer except germ cell neoplasms increases approximately ten-fold in post-menopausal women, 1 thus the availability of an animal ovarian cancer model mimicking the post-menopausal state would be most applicable to epithelial and stromal ovarian tumors. Recently, a rodent model was developed to mirror the post-menopausal state, utilizing 4-vinylcyclohexene diepoxide (VCD) to accelerate atresia of ovarian follicles. VCD selectively eradicates primordial and primary follicles from the ovary without direct effect on larger, more mature follicles resulting in a gradual onset of ovarian failure with accompanying hormonal changes emulating the human peri-menopausal state.

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“…Various optical microscopy techniques including reflectance and fluorescence [12,17,18], Raman [19], confocal [20,21], and optical coherence tomography [22,23] have been used to exploit intrinsic sources of contrast in thick tissues. Additionally, fluorescence microscopy has been combined with vital fluorescent stains such as acridine orange (AO) [24][25][26], acriflavine [27,28], and DAPI [29] to visualize micro-anatomical features in skin [24], breast [29], ovarian [26], oral [27], and esophageal [28] cancers.…”

Section: Aim 2: Optical Quantitative Biology Of Different Breast Cancmentioning

confidence: 99%

Harnessing the Power of Light to See and Treat Breast Cancer

Ramanujam¹

2013

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Public reporting burden for this collection of information is estimated to average 1 hour per response, including the time for reviewing instructions, searching existing data sources, gathering and maintaining the data needed, and completing and reviewing this collection of information. Send comments regarding this burden estimate or any other aspect of this collection of information, including suggestions for reducing this burden to Department of Defense, Washington Headquarters Services, Directorate for Information SPONSORING / MONITORING AGENCY NAME(S) AND ADDRESS(ES) U.S. Army Medical Research And Material Command SPONSOR/MONITOR'S ACRONYM(S)Fort Detrick, Maryland 21702-5012 SPONSOR/MONITOR'S REPORT NUMBER(S) DISTRIBUTION / AVAILABILITY STATEMENTApproved for public release; distribution unlimited. SUPPLEMENTARY NOTESOur objective is to exploit the wealth of physiological, metabolic, morphological and molecular sources of optical contrast to develop novel strategies that focus on two breast cancer applications: tumor margin assessment and prediction of response to neo-adjuvant therapy. The proposed aims of this grant are expected to result in three major contributions. The first has the most immediate impact. An optically based strategy that can quickly and non-destructively detect positive tumor margins will decrease the need for re-excision surgery and thereby decrease the local recurrence rate and rate of distant metastases in women electing BCS. Gaining insight into the physiological, metabolic, morphological and molecular sources of heterogeneity within and among tumors and how they are modulated by therapy, drug resistance and metastatic potential will directly benefit prognostication, prediction of outcome and planning of cancer therapies. With these tools, clinicians and clinical researchers can get a better understanding of this disease and how it might react to a drug. Basic science researchers could use it as an informed approach to study tumor biology and assay the effect of novel therapeutic agents in vivo.

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Optical imaging of the cervix

Cited by 86 publications

References 39 publications

Spectrroscopic Sensing of Cancer and Cancer Therapy: Current Status of Translational Research

Spectrroscopic Sensing of Cancer and Cancer Therapy: Current Status of Translational Research

Simultaneous optical coherence tomography and laser induced fluorescence imaging in rat model of ovarian carcinogenesis

Harnessing the Power of Light to See and Treat Breast Cancer

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