Near-IR mediated intracellular uncaging of NO from cell targeted hollow gold nanoparticles

Levy, Elizabeth; Morales, Demosthenes P.; Garcia, John V.; Reich, Norbert O.; Ford, Peter C.

doi:10.1039/c5cc07989f

Cited by 38 publications

(22 citation statements)

References 30 publications

(40 reference statements)

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“…Recently, Tortiglione and co‐workers developed a gold nanoparticle containing microcapsule and demonstrated that near‐infrared light can control the Wnt/β‐catenin signaling pathway in Hydra via photothermal uncaging of alkaline phosphatase . Efficient photothermal‐mediated uncaging requires continuous light irradiation and takes minutes or even hours . In addition to the slow uncaging, heat‐induced damage to proteins remains another major limitation.…”

Section: Introductionmentioning

confidence: 99%

Ultrafast Near‐Infrared Light‐Triggered Intracellular Uncaging to Probe Cell Signaling

Che

Mazhar

et al. 2017

Adv Funct Materials

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The possibility of regulating cell signaling with high spatial and temporal resolution within individual cells and complex cellular networks has important implications in biomedicine. In this report, we demonstrate a general strategy that uses near-infrared tissue-penetrating laser pulses to uncage biomolecules from plasmonic gold-coated liposomes, i.e. plasmonic liposomes, to activate cell signaling in a non-thermal, ultrafast and highly controllable fashion. Near-infrared picosecond laser pulse induces transient nanobubbles around plasmonic liposomes. The mechanical force generated from the collapse of nanobubbles rapidly ejects encapsulated compound within 0.1 ms. We showed that single pulse irradiation triggers the rapid intracellular uncaging of calcein from plasmonic liposomes inside endo-lysosomes. The uncaged calcein then evenly distributes over the entire cytosol and nucleus. Furthermore, we demonstrated the ability to trigger calcium signaling in both an immortalized cell line and primary dorsal root ganglion (DRG) neurons by intracellular uncaging of inositol triphosphate (IP3), an endogenous cell calcium signaling second messenger. Compared with other uncaging techniques, this ultrafast near-infrared light-driven molecular uncaging method is easily adaptable to deliver a wide range of bioactive molecules with an ultrafast optical switch, enabling new possibilities to investigate signaling pathways within individual cells and cellular networks.

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Section: Introductionmentioning

confidence: 99%

Ultrafast Near‐Infrared Light‐Triggered Intracellular Uncaging to Probe Cell Signaling

Che

Mazhar

et al. 2017

Adv Funct Materials

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“…In recent years, NO has been reported to reverse the MDR of cancer cells by reducing the expression level of P‐gp, which promptes the development of new NO delivery systems for MDR cancer chemotherapy . However, NO has a short half‐life and high sensitivity to biological substances, which greatly restricts the development of NO‐based therapeutic system in clinical applications . Furthermore, low NO concentration may promoting the growth of tumor .…”

Section: Methodsmentioning

confidence: 99%

Dual Stimuli‐Responsive Controlled Release Nanocarrier for Multidrug Resistance Cancer Therapy

Jiao

Wang

et al. 2019

ChemPhysChem

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Multidrug resistance of cancer cells is a major obstacle for cancer chemotherapy. Herein, we present a nanocarrier that can release chemotherapeutic agents to induce tumor cell death and generate NO under NIR to overcome multidrug resistance in cancer chemotherapy. Owing to the unique structure of the water channel in this controlled release system for chemotherapeutic agents, the nanocarrier surface is equipped with more active sites to graft NO donor molecules. The released NO performs very well in reversing multidrug resistance by inhibiting P‐gp expression. Our findings provide new insight into multidrug resistance cancer therapy and controlled release nanocarriers for multiple drugs.

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“…The gaseous nature has made their targeted delivery and controlled administration more challenging 108a,111. In the past two decades, researchers have developed various donors for NO and CO that are able to release the gaseous molecules under certain stimuli, such as pH, heat, and light, and some of them are already commercially available.…”

Section: Combination With Novel Oncotherapymentioning

confidence: 99%

Multifunctional Nanotherapeutics for Photothermal Combination Therapy of Cancer

Tian

Guo

Yang

2018

Advanced Therapeutics

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Recently, photothermal therapy (PTT) has demonstrated excellent results in the treatment of preclinical cancer models and thus attracted intensive interests from the research fields of material science, biochemistry, oncology, and pharmacy. Also, its combination with other cancer therapies shows great promise for clinical application: PTT is able to make up for the drawbacks of others and improve the prognosis through various synergistic effects. In these combination therapies, design of nanoscale multifunctional therapeutics is key to achieve enhanced or even synergistic therapeutic effect. Herein, the recent progress is summarized in the development of strategies involving combination of PTT with other cancer therapies, conventional or emerging, with increased efficacy. The highlight lies in integrating various functional units to form multifunctional nanomaterials that play the role of photothermal agents as well as other therapeutics in a combination therapy and the design of an effective targeted delivery system for them. Smart combination of therapies will undoubtedly improve the therapeutic efficacy and make a contribution to the advancement in fighting cancer.

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Near-IR mediated intracellular uncaging of NO from cell targeted hollow gold nanoparticles

Abstract: NIR light triggers NO delivery with unprecedented spatio-temporal control inside prostate cancer cells from surface-modified hollow gold nanoshells.

Cited by 38 publications

References 30 publications

Ultrafast Near‐Infrared Light‐Triggered Intracellular Uncaging to Probe Cell Signaling

Ultrafast Near‐Infrared Light‐Triggered Intracellular Uncaging to Probe Cell Signaling

Dual Stimuli‐Responsive Controlled Release Nanocarrier for Multidrug Resistance Cancer Therapy

Multifunctional Nanotherapeutics for Photothermal Combination Therapy of Cancer

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