Near-infrared-triggered in situ hybrid hydrogel system for synergistic cancer therapy

Zhang, Huijuan; Zhu, Xiali; Ji, Yandan; Jiao, Xiaojing; Chen, Qianqian; Hou, Lin; Zhang, Hongling; Zhang, Zhenzhong

doi:10.1039/c5tb00904a

Cited by 69 publications

(47 citation statements)

References 57 publications

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“…SEM was also utilized to observe the morphology of PSiNPs/PEGDA hydrogels. Figure (b) presented the homogeneously ripple‐like networks of PEGDA crosslinking, similar with TiO 2 /PEGDA hydrogels . With NIR laser power intensity or PSiNPs concentration increasing, the width of these ripples became larger, due to the enhanced degree of PEGDA crosslinking.…”

Section: Resultsmentioning

confidence: 66%

“…And DOX release profiles of PSiNPs/PEGDA/DOX hydrogels were mainly dependent on PSiNPs concentration incorporated into hydrogels, not pH value. Notably, when PSiNPs concentration was 1.2 mg mL −1 , the maximum release ratio could reach over 80%, much higher than that (<10%) of TiO 2 /PEGDA hydrogels …”

Section: Resultsmentioning

confidence: 87%

“…Recently, in the presence of inorganic nanoparticles‐based nanocomposites (such as titanium oxide [TiO 2 ], oxidized graphene, and carbon nanotube, etc.) as photosensitizers, singlet oxygen ( 1 O 2 ) was generated by near‐infrared (NIR) light to initiate in situ polymerization of poly(ethylene glycol) double acrylates (PEGDA) . In comparison with traditional UV or visible light, NIR light has remarkably deeper penetration and negligible photo‐damage in body, which is more suitable for local cancer therapy in vivo .…”

Section: Introductionmentioning

confidence: 99%

“…In comparison with traditional UV or visible light, NIR light has remarkably deeper penetration and negligible photo‐damage in body, which is more suitable for local cancer therapy in vivo . However, some concerns regarding the toxicity of TiO 2 nanoparticles, and nondegradable PEGDA hydrogels with low drug release efficiency (<10%), impeded their further clinical applications.…”

Section: Introductionmentioning

confidence: 99%

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NIR light‐triggered gelling in situ of porous silicon nanoparticles/PEGDA hybrid hydrogels for localized combinatorial therapy of cancer cells

Xia

Zhang

Shi

et al. 2018

J of Applied Polymer Sci

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Porous silicon-based nanocomposite hydrogels were readily constructed with the gelation of poly(ethylene glycol) double acrylates (PEGDA) macromers, due to the initiation of singlet oxygen photosensitized with porous silicon nanoparticles (PSiNPs) under near-infrared (NIR) light irradiation. Multifunctional PSiNPs/PEGDA nanocomposite hydrogels showed strong fluorescence, excellent biodegradability, significant photothermal effect, and sustained drug release with high efficiency (>80%). Finally, in situ growth of PSiNPs/PEGDA hybrid hydrogels on cancer cells was also achieved by NIR light, and then their biodegradation, drug release and synergistic chemo-phototherapeutic efficacy were further demonstrated, which could provide a significant localized inhibition for the viability, adherence, and migration of cancer cells in vitro. Thus, we suggested that these resultant hybrid hydrogels would have important potential on local cancer therapy in future clinical practice.

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Section: Resultsmentioning

confidence: 66%

Section: Resultsmentioning

confidence: 87%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

NIR light‐triggered gelling in situ of porous silicon nanoparticles/PEGDA hybrid hydrogels for localized combinatorial therapy of cancer cells

Xia

Zhang

Shi

et al. 2018

J of Applied Polymer Sci

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“…The composite hydrogel shell on cancer cells exhibits several competitive advantages including enhanced antitumor effect by retaining the high concentration of drugs around cancer cells, excellent PDT/PTT compatibility as well as high loading and controllable release of fluorouracil (5-FU) for synergetic multimodal treatment. In another work, Zhang et al [58] developed a DOX-loaded PEGDA photoinduced hydrogel triggered by NIR laser irradiation. In this in-situ drug delivery system, the TiO2@multi-walled carbon nanotube (TiO2@MWCNT) nanocomposite was explored as the photoinitiator and a PS-photothermal agent for intermittent tumor therapy with multi-mechanisms by a single NIR laser.…”

Section: Other Phototherapy-involving Combination Therapymentioning

confidence: 99%

Hydrogel-based phototherapy for fighting cancer and bacterial infection

et al. 2017

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Hydrogels constitute a group of polymeric materials which can hold a large amount of water in their three-dimensional networks due to their hydrophilic structures. In the past few years, they have been researched for various biomedical applications, such as drug/cell carriers, tissue engineering, and biosensors. Particularly, the hydrogels used as drug delivery systems have shown distinct advantages in phototherapy. This review presents recent advancements of hydrogel's use in phototherapeutic applications by focusing on three kinds of phototherapeutic methods including photodynamic therapy (PDT), photothermal therapy (PTT), and phototherapy-containing combination therapy (PCCT). The applications of these therapies in anticancer and antibacterial fields have also been summarized. We hope that this review will inspire researchers to further develop promising materials for phototherapy applications.

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Releasing Acceptor from Donor Matrix to Accelerate Crystallization Kinetics with a Second Donor toward High‐Efficiency Green‐Printable Organic Photovoltaics

Xue

Zhao

et al. 2023

Adv Funct Materials

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The state‐of‐the‐art power conversion efficiency (PCE) of organic solar cells (OSCs) is typically achieved in the devices fabricated by toxic halogen solvents with complex post‐treatment processes in strictly inert atmosphere. Developing suitable processing method for printing in ambient air using eco‐friendly solvents with continuous solution supply and fabricating efficient devices without any post‐treatment are intensively desired. Controlling the crystallization kinetics to fine‐tune the acceptor's assembly behavior with a second donor for favorable morphological evolution is an effective approach to achieve above requirements. Herein, a kinetics‐controlling strategy is implemented by introducing a strong crystalline small molecule, BTR‐Cl, to enhance the crystallinity of acceptors. The combined in situ spectra characterizations revealed that the earlier aggregation of acceptor and modulation in conformation of PM6 can be achieved. This unique aggregation behavior facilitated enhanced film crystallization with reduced paracrystallinity of π–π stacking, resulting in improved charge transport and inhibited charge recombination. An outstanding PCE of 17.50% is obtained for the device processed with o‐xylene via ambient air printing without any post‐treatment. More significantly, efficient all‐printed inverted devices and large‐area modules are prepared. The generalization of this strategy has been confirmed in other efficient systems, suggesting a great potential for universally fabricating high‐efficiency and eco‐friendly OSCs.

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Near-infrared-triggered in situ hybrid hydrogel system for synergistic cancer therapy

Abstract: The photo-polymerization of PEGDA hydrogel and its synergetic anti-tumor effect triggered by a single NIR laser.

Cited by 69 publications

References 57 publications

NIR light‐triggered gelling in situ of porous silicon nanoparticles/PEGDA hybrid hydrogels for localized combinatorial therapy of cancer cells

NIR light‐triggered gelling in situ of porous silicon nanoparticles/PEGDA hybrid hydrogels for localized combinatorial therapy of cancer cells

Hydrogel-based phototherapy for fighting cancer and bacterial infection

Releasing Acceptor from Donor Matrix to Accelerate Crystallization Kinetics with a Second Donor toward High‐Efficiency Green‐Printable Organic Photovoltaics

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