Cell-mediated drug-delivery systems have received considerable attention for their enhanced therapeutic specificity and efficacy in cancer treatment. Neutrophils (NEs), the most abundant type of immune cells, are known to penetrate inflamed brain tumours. Here we show that NEs carrying liposomes that contain paclitaxel (PTX) can penetrate the brain and suppress the recurrence of glioma in mice whose tumour has been resected surgically. Inflammatory factors released after tumour resection guide the movement of the NEs into the inflamed brain. The highly concentrated inflammatory signals in the brain trigger the release of liposomal PTX from the NEs, which allows delivery of PTX into the remaining invading tumour cells. We show that this NE-mediated delivery of drugs efficiently slows the recurrent growth of tumours, with significantly improved survival rates, but does not completely inhibit the regrowth of tumours.

Improving charge extraction and suppressing charge recombination are critically important to minimize the loss of absorbed photons and improve the device performance of polymer solar cells (PSCs). In this work, highly efficient PSCs are demonstrated by progressively improving the charge extraction and suppressing the charge recombination through the combination of side‐chain engineering of new nonfullerene acceptors (NFAs), adopting ternary blends, and introducing volatilizable solid additives. The 2D side chains on BTP‐Th induce a certain steric hindrance for molecular packing and phase separation, which is mitigated by fluorination of side chains on BTP‐FTh. Moreover, by introducing two highly crystalline molecules as the second acceptor and volatilizable solid additive, respectively, into the BTP‐FTh‐based host blend, the molecular crystallinity is significantly improved and the blend morphology is finely optimized. As expected, enhanced charge extraction and suppressed charge recombination are progressively realized, contributing to the largely improved fill factor (FF) of the resultant devices. Accompanied by the enhanced open‐circuit voltage (Voc) and short‐circuit current density (Jsc), a record high power conversion efficiency (PCE) of 19.05% is realized finally.

To achieve deep tumor penetration of large-sized nanoparticles (NPs), we have developed a reversible swelling-shrinking nanogel in response to pH variation for a sequential intra-intercellular NP delivery. The nanogel had a crosslinked polyelectrolyte core, consisting of N-lysinal-N'-succinyl chitosan and poly(N-isopropylacrylamide), and a crosslinked bovine serum albumin shell, which was able to swell in an acidic environment and shrink back under neutral conditions. The swelling resulted in a rapid release of the encapsulated chemotherapeutics in the cancer cells for efficient cytotoxicity. After being liberated from the dead cells, the contractive nanogel could infect neighboring cancer cells closer to the center of the tumor tissue.

Zwitterionic oligopeptide liposomes (HHG2C(18)-L) containing a smart lipid (1,5-dioctadecyl-L-glutamyl 2-histidyl-hexahydrobenzoic acid, HHG2C(18)) are developed to overcome the barriers faced by anticancer drugs on the route from the site of injection into the body to the final antitumor target within transport steps with multiple physiological and biological barriers. HHG2C(18)-L show the multistage pH-responsive to the tumor cell (the mitochondria in this case). Their multistage pH response leads to more effective entry of the tumor cell, improved escape from the endolysosomes, and accumulation at the mitochondria (see picture).

Power conversion efficiency (PCE) of organic solar cells (OSCs) has crossed the 18% mark for OSCs, which are largely fabricated by spin‐coating, and the optimal photoactive thickness is limited to 100 nm. To increase reproducibility of results with industrial roll‐to‐roll (R2R) processing, slot‐die coating coupled with a ternary strategy for optimal performance of large‐area, thick OSCs is used. Based on miscibility differences, a highly crystalline molecule, BTR‐Cl, is incorporated, and the phase‐separation kinetics of the D18:Y6 film is regulated. BTR‐Cl provides an early liquid–liquid phase separation and early aggregation of Y6, which slightly improves the molecular crystallinity and vertical phase separation of the ternary blends, resulting in high PCEs of 17.2% and 15.5% for photoactive films with thicknesses of 110 and 300 nm, respectively. The ternary design strategy for large‐area and thick films is further used to fabricate high‐efficiency flexible devices, which promises reproducibility of the lab results from slot‐die coating to industrial R2R manufacturing.