Near-Infrared Spectroscopy of Amine Salts

Sinsheimer, Joseph E.; Keuhnelian, Anne M.

doi:10.1002/jps.2600551115

Cited by 20 publications

(2 citation statements)

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“…Meanwhile, there was no -NH bending vibration detected in the neat 3DMAP and 3DEAP due to the absence of -NH bond in the tertiary alkanolamine (3DMAP and 3DEAP). However, in the 3DMAPS spectrum, a new weak peak was observed at 1625.70 cm -1 and at 1626.18 cm -1 in 3DEAPS, which denotes the vibration peaks of protonated tertiary amine -NH + [17,18]. On top of that, the carboxylate anion (-COO -) was detected at 1377.408 and 1379.818 cm -1 in the spectrum of the 3DMAPS and 3DEAPS, respectively.…”

Section: Ftir Spectroscopymentioning

confidence: 92%

Salicylate-Based Protic Ionic Liquids as a Potential Antioxidant

2019

MJAS

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Salicylate-based protic ionic liquids (PILs) were synthesised, characterised and assessed in this study for potential antioxidant in drug design. The synthesised PILs were known as 3-dimethylamino-1-propanol salicylate (3DMAPS) and 3-diethylamino-1propanol salicylate (3DEAPS). Proton nuclear magnetic resonance ( 1 HNMR), Fourier transformation infrared spectroscopy (FTIR) and thermogravimetric analysis (TGA) were used to characterise the synthesised PILs. Furthermore, the antioxidant activity of the synthesised PILs was determined using the 2,2-diphenyl-1-picrylhydrazyl (DPPH) free radical assay. Both 3DMAPS and 3DEAPS showed a good antioxidant activity compared to parent acid (salicylic acid) as these two compounds could scavenge 20% of DPPH free radical at a concentration of 66.76 ± 0.09 µM and 27.27 ± 0.10 µM, respectively. AbstrakCecair ionik protik (PILs) berasaskan salisilat disintesis, dicirikan dan dinilai untuk potensi antioksidan dalam reka bentuk dadah. Dua PILs iaitu 3-dimetilamino-1-propanol salisilat (3DMAPS) dan 3-diethilamino-1-propanol salisilat (3DEAPS) telah berjaya disintesis. Proton resonans magnetik nuklear ( 1 HNMR), spektroskopi transformasi inframerah (FTIR) dan analisis termogravimetrik (TGA) digunakan untuk pencirian PIL yang di sintesis. Tambahan pula, aktiviti antioksidan PIL ditentukan dengan menggunakan ujian radikal bebas 2,2-difenil-1-pikrilhidrazil (DPPH). Kedua-dua 3DMAPS dan 3DEAPS menunjukkan aktiviti antioksidan yang baik berbanding dengan asid induk (asid salisilat) kerana kedua-dua sebatian ini boleh membakar 20% radikal bebas DPPH masing-masing pada kepekatan 66.76 ± 0.09 μM dan 27.27 ± 0.10 μM.Kata kunci: cecair ionic protik, asid salisilik, perangkap radikal, radikal bebas, ujian DPPH

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