Near infrared spectroscopy in brain injury: today’s perspective

Al-Rawi, Pippa G.

doi:10.1007/3-211-32318-x_93

Cited by 32 publications

(11 citation statements)

References 57 publications

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“…Amongst many potential applications, NIRS/DOS has been utilized for cerebral monitoring of adults with traumatic brain injury (TBI) and subarachnoid hemorrhage (SAH) [440–445], ischemic stroke [80, 277–280, 446–453], sleep apnea and other sleep disorders [454–457], intraoperative brain monitoring [458, 459] and in neonates and children [433, 460–462]. This list is not exhaustive; it is meant to give a “flavor” of the field.…”

Section: Optical Monitoring Of Cerebral Hemodynamicsmentioning

confidence: 99%

Diffuse optics for tissue monitoring and tomography

et al. 2010

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This review describes the diffusion model for light transport in tissues and the medical applications of diffuse light. Diffuse optics is particularly useful for measurement of tissue hemodynamics, wherein quantitative assessment of oxy- and deoxy-hemoglobin concentrations and blood flow are desired. The theoretical basis for near-infrared or diffuse optical spectroscopy (NIRS or DOS, respectively) is developed, and the basic elements of diffuse optical tomography (DOT) are outlined. We also discuss diffuse correlation spectroscopy (DCS), a technique whereby temporal correlation functions of diffusing light are transported through tissue and are used to measure blood flow. Essential instrumentation is described, and representative brain and breast functional imaging and monitoring results illustrate the workings of these new tissue diagnostics.

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Section: Optical Monitoring Of Cerebral Hemodynamicsmentioning

confidence: 99%

Diffuse optics for tissue monitoring and tomography

et al. 2010

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“…7,8 Our group has developed a continuous-wave ͑CW͒, nearinfrared spectroscopy ͑NIRS͒ technique for measuring CBF in newborns. [9][10][11] The technique is based on bolus-tracking theory 12 and uses the near-infrared light absorbing dye indocyanine green ͑ICG͒ as an intravascular contrast agent.…”

Section: Introductionmentioning

confidence: 99%

Comparison of time-resolved and continuous-wave near-infrared techniques for measuring cerebral blood flow in piglets

et al. 2010

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Abstract.A primary focus of neurointensive care is monitoring the injured brain to detect harmful events that can impair cerebral blood flow ͑CBF͒, resulting in further injury. Since current noninvasive methods used in the clinic can only assess blood flow indirectly, the goal of this research is to develop an optical technique for measuring absolute CBF. A time-resolved near-infrared ͑TR-NIR͒ apparatus is built and CBF is determined by a bolus-tracking method using indocyanine green as an intravascular flow tracer. As a first step in the validation of this technique, CBF is measured in newborn piglets to avoid signal contamination from extracerebral tissue. Measurements are acquired under three conditions: normocapnia, hypercapnia, and following carotid occlusion. For comparison, CBF is concurrently measured by a previously developed continuous-wave NIR method. A strong correlation between CBF measurements from the two techniques is revealed with a slope of 0.79± 0.06, an intercept of −2.2± 2.5 ml/ 100 g / min, and an R 2 of 0.810± 0.088. Results demonstrate that TR-NIR can measure CBF with reasonable accuracy and is sensitive to flow changes. The discrepancy between the two methods at higher CBF could be caused by differences in depth sensitivities between continuous-wave and time-resolved measurements. © 2010 Society of Photo-Optical Instrumentation Engineers.

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“…Near‐infrared spectroscopy (NIRS) is well established as a non‐invasive method of detecting changes in brain total haemoglobin concentration and oxygenation. NIRS provides a unique opportunity for continuous and non‐invasive bedside recording of brain oxygenation in patients with stroke [1,2] and head injury [3,4]. The method is based on the fact that near‐infrared light can penetrate biological tissue and is predominantly absorbed by haemoglobin.…”

Section: Introductionmentioning

confidence: 99%

Changes in cerebral blood flow after acetazolamide: an experimental study comparing near‐infrared spectroscopy and SPECT

Schytz

Wienecke

Jensen

et al. 2009

Euro J of Neurology

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Background and purpose-It is important to find a reliable and bedside method, which can estimate the cerebral blood flow (CBF) of patients in clinical settings. Estimation of CBF by calculating a blood flow index (BFI) using continuous wave near-infrared spectroscopy (CW-NIRS) and indocyanine green (ICG) as an iv tracer has been proposed to be a feasible and promising method. To validate if the BFI method can detect relative changes in CBF we compared data with the established method 133 Xenon single photon emission computer tomography ( 133 Xe-SPECT).

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Near infrared spectroscopy in brain injury: today’s perspective

Cited by 32 publications

References 57 publications

Diffuse optics for tissue monitoring and tomography

Diffuse optics for tissue monitoring and tomography

Comparison of time-resolved and continuous-wave near-infrared techniques for measuring cerebral blood flow in piglets

Changes in cerebral blood flow after acetazolamide: an experimental study comparing near‐infrared spectroscopy and SPECT

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