Comparison of time-resolved and continuous-wave near-infrared techniques for measuring cerebral blood flow in piglets

Diop, Mamadou; Tichauer, Kenneth M.; Elliott, Jonathan T.; Migueis, Mark; Lee, Ting‐Yim; Lawrence, Keith St.

doi:10.1117/1.3488626

Cited by 62 publications

(49 citation statements)

References 45 publications

(64 reference statements)

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“…It was shown that optical monitoring of the inflow and washout of the dye allows assessing cerebral blood flow [19][20][21][22] and cerebral blood volume [22][23][24]. Recently, it was shown that advanced optical techniques can be used in monitoring of the inflow and washout of ICG in brain tissues, which constitutes a good basis for development of a clinical useful method, easy to apply in Intensive Care Units (ICU) in monitoring of brain perfusion in critically ill patients [25].…”

Section: Introductionmentioning

confidence: 99%

Neurotoxic effects of indocyanine green -cerebellar granule cell culture viability study

Toczyłowska

Ziemińska

Goch

et al. 2014

Biomed. Opt. Express

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Abstract:The aim of this study was to examine neurotoxicity indocyanine green (ICG). We assessed viability of primary cerebellar granule cell culture (CGC) exposed to ICG to test two mechanisms that could be the first triggers causing neuronal toxicity: imbalance in calcium homeostasis and the degree of oligomerization of ICG molecules. We have observed this imbalance in CGC after exposure to 75-125μΜ ICG and dose and application sequence dependent protective effect of Gadovist on surviving neurons in vitro when used with ICG. Spectroscopic studies suggest the major cause of toxicity of the ICG is connected with oligomers formation. ICG at concentration of 25 μM (which is about 4 times higher than the highest concentration of ICG in the brain applied in in-vivo human studies) is not neurotoxic in the cell culture. Orlock, and C. A. Puliafito, "Adverse reactions due to indocyanine green," Ophthalmology 101(3), 529-533 (1994). 2. B. F. Hochheimer, "Angiography of the retina with indocyanine green," Arch. Ophthalmol. 86(5), 564-565 (1971). 3. J. Fishbaugh, "Retina: indocyanine green (ICG) angiography," Insight 19(3), 30-32 (1994). 4. J. Caesar, S. Shaldon, L. Chiandussi, L. Guevara, and S. Sherlock, "The use of indocyanine green in the measurement of hepatic blood flow and as a test of hepatic function," Clin. Sci. 21, 43-57 (1961). 5. A. El-Desoky, A. M. Seifalian, M. Cope, D. T. Delpy, and B. R. Davidson, "Experimental study of liver dysfunction evaluated by direct indocyanine green clearance using near infrared spectroscopy," Br. J. Surg. 1005-1011 (1999). 6. T. Ishizawa, N. Fukushima, J. Shibahara, K. Masuda, S. Tamura, T. Aoki, K. Hasegawa, Y. Beck, M. Fukayama, and N. Kokudo, "Real-time identification of liver cancers by using indocyanine green fluorescent imaging," Cancer 115(11), 2491-2504 (2009 4998-5003 (2006). 17. T. L. Jackson, "Indocyanine green accused," Br. J. Ophthalmol. 89(4), 395-396 (2005). Reson. Imaging 14(6), 619-623 (1996). 77. D. E. Ray, J. B. Cavanagh, C. C. Nolan, and S. C. Williams, "Neurotoxic effects of gadopentetate dimeglumine: behavioral disturbance and morphology after intracerebroventricular injection in rats," AJNR Am. J. Neuroradiol. 17(2), 365-373 (1996). 78. X. Feng, Q. Xia, L. Yuan, X. Yang, and K. Wang, "Impaired mitochondrial function and oxidative stress in rat cortical neurons: implications for gadolinium-induced neurotoxicity," Neurotoxicology 31(4), 391-398 (2010). 79. M. P. Mattson and Y. Goodman, "Different amyloidogenic peptides share a similar mechanism of neurotoxicity involving reactive oxygen species and calcium," Brain Res. 676(1), 219-224 (1995). 86(8),

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Section: Introductionmentioning

confidence: 99%

Neurotoxic effects of indocyanine green -cerebellar granule cell culture viability study

Toczyłowska

Ziemińska

Goch

et al. 2014

Biomed. Opt. Express

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“…The PMT was connected to a time-correlated single photon counting (TCSPC) module (HydraHarp 400, PicoQuant, Germany) to generate temporal-point-spread functions (TPSFs) from the collected photons. The instrument response function (IRF) was also measured using our previously described method [42,43].…”

Section: Instrumentationmentioning

confidence: 99%

Joint blood flow is more sensitive to inflammatory arthritis than oxyhemoglobin, deoxyhemoglobin, and oxygen saturation

Rajaram

Ioussoufovitch

Morrison

et al. 2016

Biomed. Opt. Express

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Joint hypoxia plays a central role in the progression and perpetuation of rheumatoid arthritis (RA). Thus, optical techniques that can measure surrogate markers of hypoxia such as blood flow, oxyhemoglobin, deoxyhemoglobin, and oxygen saturation are being developed to monitor RA. The purpose of the current study was to compare the sensitivity of these physiological parameters to arthritis. Experiments were conducted in a rabbit model of RA and the results revealed that joint blood flow was the most sensitive to arthritis and could detect a statistically significant difference (p<0.05, power = 0.8) between inflamed and healthy joints with a sample size of only four subjects. Considering that this a quantitative technique, the high sensitivity to arthritis suggests that joint perfusion has the potential to become a potent tool for monitoring disease progression and treatment response in RA.

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“…In several studies the technique of monitoring of the dye inflow and washout was validated as a tool for estimation of cerebral hemodynamic parameters [9][10][11][12]. Critical problem associated with the use of the NIRS-based techniques is connected with the fact that the measured signals are sensitive to changes in oxygenation and perfusion of intraand extra-cerebral tissue compartments [13].…”

Section: Introductionmentioning

confidence: 99%

An algorithm for assessment of inflow and washout of optical contrast agent to the brain by analysis of time-resolved diffuse reflectance and fluorescence signals

Milej

Kruczkowski

Gerega

et al. 2013

2013 35th Annual International Conference of the IEEE Engineering in Medicine and Biology Society (EMBC)

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In optical measurements of the brain oxygenation and perfusion the problem of contamination of the signals with the components related to the extracerebral tissues remains an obstacle limiting clinical applicability of the technique. In this paper we present an algorithm allowing for derivation of signals related to the changes in absorption in the intracerebral tissues based on analysis of time-resolved diffuse reflectance and fluorescence. The proposed method was validated in series of Monte Carlo simulations in which inflow and washout of an optical contrast agent into the two-layered human head model was considered. It was shown that the decomposed intracerebral component of the signal can be derived with uncertainty of about 5%. This result suggests that the method proposed can be applied in improved estimation of brain perfusion parameters based on the bolus-tracking technique.

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Comparison of time-resolved and continuous-wave near-infrared techniques for measuring cerebral blood flow in piglets

Cited by 62 publications

References 45 publications

Neurotoxic effects of indocyanine green -cerebellar granule cell culture viability study

Neurotoxic effects of indocyanine green -cerebellar granule cell culture viability study

Joint blood flow is more sensitive to inflammatory arthritis than oxyhemoglobin, deoxyhemoglobin, and oxygen saturation

An algorithm for assessment of inflow and washout of optical contrast agent to the brain by analysis of time-resolved diffuse reflectance and fluorescence signals

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