Neurotoxic effects of indocyanine green -cerebellar granule cell culture viability study

Toczyłowska, Beata; Ziemińska, Elżbieta; Goch, Grażyna; Milej, Daniel; Gerega, Anna; Liebert, Adam

doi:10.1364/boe.5.000800

Cited by 17 publications

(11 citation statements)

References 77 publications

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“…Additionally, we did not recognize any side effects associated with the examination in this series of patients, in contrast to previous evidence of a minimal risk of neurotoxicity in two previous studies 15 , 16 . Nevertheless, we suggest that the NIRS/ICG test is a very safe test that can easily be performed even on the bedside, and that the dynamics of ICG measured via NIRS can be taken to reflect the local cerebral circulation.…”

Section: Discussioncontrasting

confidence: 97%

Bedside assessment of regional cerebral perfusion using near-infrared spectroscopy and indocyanine green in patients with atherosclerotic occlusive disease

Saitô

Ishikawa

Tanabe

et al. 2018

Sci Rep

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This pilot study aimed to investigate the utility of near-infrared spectroscopy/indocyanine green (NIRS/ICG) for examining patients with occlusive cerebrovascular disease. Twenty-nine patients with chronic-stage atherosclerotic occlusive cerebrovascular disease were included. The patients were monitored using NIRS at the bedside. Using ICG time-intensity curves, the affected-to-unaffected side ratios were calculated for several parameters, including the maximum ICG concentration (ΔICGmax), time to peak (TTP), rise time (RT), and blood flow index (BFI = ΔICGmax/RT), and were compared to the affected-to-unaffected side ratios of the regional cerebral blood flow (rCBF) and regional oxygen extraction fraction (rOEF) obtained using positron emission tomography with 15O-labeled gas. The BFI ratio showed the best correlation with the rCBF ratio among these parameters (r = 0.618; P = 0.0004), and the RT ratio showed the best correlation with the rOEF ratio (r = 0.593; P = 0.0007). The patients were further divided into reduced rCBF or elevated rOEF groups, and the analysis revealed significant related differences. The present results advance the measurement of ICG kinetics using NIRS as a useful tool for the detection of severely impaired perfusion with reduced rCBF or elevated rOEF. This method may be applicable as a monitoring tool for patients with acute ischemic stroke.

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Section: Discussioncontrasting

confidence: 97%

Bedside assessment of regional cerebral perfusion using near-infrared spectroscopy and indocyanine green in patients with atherosclerotic occlusive disease

Saitô

Ishikawa

Tanabe

et al. 2018

Sci Rep

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“…[23] The conjugation of FA causes two specific bands to appear at l % 300 and 380 nm, and they correspond to the aromatic moiety of the FA compartment. [25] Consequently,t he addition of ICG resultsi namarked absorbance at l = 660 and 780 nm, which confirms that ICG is loaded onto FA-CD. [26] To analyze the pH/redox responsiveness of the nanoparticles, we analyzed the absorption properties of ICG-CD by UV/Vis spectroscopy under pH, GSH, and combined pH/redox (GSH) treatments.…”

Section: Resultsmentioning

confidence: 62%

“…As shown in Figure b, the UV/Vis‐NIR absorption spectrum of ICG‐CD demonstrates a wide band at λ ≈250–420 nm that is indicative of the π–π bonds of the polymer dots species . The conjugation of FA causes two specific bands to appear at λ ≈300 and 380 nm, and they correspond to the aromatic moiety of the FA compartment . Consequently, the addition of ICG results in a marked absorbance at λ= 660 and 780 nm, which confirms that ICG is loaded onto FA‐CD .…”

Section: Resultsmentioning

confidence: 67%

pH/Redox‐Triggered Photothermal Treatment for Cancer Therapy Based on a Dual‐Responsive Cationic Polymer Dot

et al. 2018

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In the present study, a pH/redox‐responsive cationic polymer dot (CD) was successfully prepared for a near‐infrared (NIR)‐mediated, simultaneously controllable photothermal temperature guided imaging off/on system to monitor therapeutic delivery. Carbonized disulfide cross‐linked branched polyethyleneimine (bPEI) was conjugated with folic acid (FA) as a targeting moiety and partially formed an ionic complex with anionic indocyanine green (ICG) to afford a bPEI‐based CD (ICG‐CD). This was responsive to mild reductive (glutathione, GSH) and acidic tumor conditions, which enabled the simultaneous biodegradation of those hydrophobic and complex sites. The ICG‐CD internalized readily into the cytoplasm of cancer cells by a FA receptor and cationic‐mediated endocytosis in the off state, whereas if ICG‐CD met intracellular GSH at high concentrations, GSH contributed partially to the recovery of fluorescence and was then internalized into acidic endosomes to induce complete restoration of fluorescence. This tumor‐sensitive degradability of the CD not only facilitated ICG release in the tumor location but also allowed controllable photothermal therapy effects of nanoparticles under NIR irradiation, which resulted in improved cancer therapy. Taken together, the results indicate great potential in tumor targeting, intracellular imaging, and controllable therapeutic delivery through a fluorescence off/on assay under the pH/redox conditions of cancer cells.

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“… 17 , 27–30 Its concentration does not influence lymphatic function. 31 Only rare cases of allergy, 32 when intravenously injected at high dosages have been reported, but no other evidence of adverse effects such as neurotoxicity 33 are reported. Until the present, we have performed more than thousand NIRFLI in patients and normal subjects and have never observed any adverse effects.…”

Section: Methodsmentioning

confidence: 99%

Near-Infrared Fluorescence Lymphatic Imaging to Reconsider Occlusion Pressure of Superficial Lymphatic Collectors in Upper Extremities of Healthy Volunteers

Belgrado

Vandermeeren

Vankerckhove

et al. 2016

Lymphatic Research and Biology

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Background: There are very little scientific data on occlusion pressure for superficial lymphatic collectors. Given its importance in determining the transport capacity of lymphatic vessels, it is crucial to know its value. The novel method of near-infrared fluorescence lymphatic imaging (NIRFLI) can be used to visualize lymphatic flow in real time. The goal of this study was to see if this method could be used to measure the lymphatic occlusion pressure.Methods: We observed and recorded lymph flow in the upper limb of healthy volunteers through a transparent cuff using near-infrared fluorescence lymphatic imaging. After obtaining a baseline of the lymph flow without pressure inside the cuff, the cuff was inflated by increments of 10 mm Hg starting at 30 mm Hg. A NIRFLI guided manual lymphatic drainage technique named “Fill & Flush Drainage Method” was performed during the measurement to promote lymph flow. Lymphatic occlusion pressure was determined by observing when lymph flow stopped under the cuff.Results: We measured the lymphatic occlusion pressure on 30 healthy volunteers (11 men and 19 women). Mean lymphatic occlusion pressure in the upper limb was 86 mm Hg (CI ±3.7 mm Hg, α = 0.5%). No significant differences were found between age groups (p = 0.18), gender (p = 0.12), or limb side (p = 0.85).Conclusions: NIRFLI, a transparent sphygmomanometer cuff and the “Fill and Flush” manual lymphatic drainage method were used to measure the lymphatic occlusion pressure in 30 healthy humans. That combination of these techniques allows the visualization of the lymph flow in real time, while ensuring the continuous filling of the lymph collectors during the measurement session, reducing false negative observations. The measured occlusion pressures are much higher than previously described in the medical literature.

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Neurotoxic effects of indocyanine green -cerebellar granule cell culture viability study

Cited by 17 publications

References 77 publications

Bedside assessment of regional cerebral perfusion using near-infrared spectroscopy and indocyanine green in patients with atherosclerotic occlusive disease

Bedside assessment of regional cerebral perfusion using near-infrared spectroscopy and indocyanine green in patients with atherosclerotic occlusive disease

pH/Redox‐Triggered Photothermal Treatment for Cancer Therapy Based on a Dual‐Responsive Cationic Polymer Dot

Near-Infrared Fluorescence Lymphatic Imaging to Reconsider Occlusion Pressure of Superficial Lymphatic Collectors in Upper Extremities of Healthy Volunteers

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