Near-Infrared-Responsive Cancer Photothermal and Photodynamic Therapy Using Gold Nanoparticles

Kim, Hyung Shik; Lee, Dong Yun

doi:10.3390/polym10090961

Cited by 189 publications

(152 citation statements)

References 85 publications

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“…The sharp penetration and minor nonspecic and non-uniform distribution of photothermal heating in the NIR window can result in lower light absorption by the tissues and in greater transparency within the optical window. 34 In particular, novel materials with high optical absorbance in the NIR region for PTT include gold nanoshells, 34 gold nanorods 35,36 and CNTs. [37][38][39] In Table 1, the photothermal therapies utilising different materials and an 808 nm diode laser are demonstrated with the effective laser intensity of 0.7-9.2 W cm À2 .…”

Section: Introductionmentioning

confidence: 99%

Development of hydrophobic reduced graphene oxide as a new efficient approach for photochemotherapy

et al. 2020

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Section: Introductionmentioning

confidence: 99%

Development of hydrophobic reduced graphene oxide as a new efficient approach for photochemotherapy

et al. 2020

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“…[22], Copyright , The Royal Society of Chemistry, 2017. (g) Different localised surface plasmon resonance (LSPR) tuning the size of Au NPs [36] and shape (h-k). Reproduced with permission from [37], Copyright Elsevier, 2019 [22], Copyright, The Royal Society of Chemistry, 2017.…”

Section: Plasmonic Nps: Au Nps and Ag Npsmentioning

confidence: 99%

Green Plasmonic Nanoparticles and Bio-Inspired Stimuli-Responsive Vesicles in Cancer Therapy Application

et al. 2020

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In the last years, there is a growing interest in the application of nanoscaled materials in cancer therapy because of their unique physico-chemical properties. However, the dark side of their usability is limited by their possible toxic behaviour and accumulation in living organisms. Starting from this assumption, the search for a green alternative to produce nanoparticles (NPs) or the discovery of green molecules, is a challenge in order to obtain safe materials. In particular, gold (Au NPs) and silver (Ag NPs) NPs are particularly suitable because of their unique physico-chemical properties, in particular plasmonic behaviour that makes them useful as active anticancer agents. These NPs can be obtained by green approaches, alternative to conventional chemical methods, owing to the use of phytochemicals, carbohydrates, and other biomolecules present in plants, fungi, and bacteria, reducing toxic effects. In addition, we analysed the use of green and stimuli-responsive polymeric bio-inspired nanovesicles, mainly used in drug delivery applications that have revolutionised the way of drugs supply. Finally, we reported the last examples on the use of metallic and Au NPs as self-propelling systems as new concept of nanorobot, which are able to respond and move towards specific physical or chemical stimuli in biological entities.

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“…Many thermal sources are used for this method, such as microwave, radiofrequency and nearinfrared light. [1][2][3] As a local therapeutic modality, photothermal therapy (PTT) utilizes photoabsorbers to generate heat from near-infrared light absorption, leading to the thermal ablation of cancer cells. 4 During PTT, chromophores contained in healthy tissue within the light path can also absorb energy, reducing the effectiveness of heat deposition within tumor cells and increasing nonspecific injury to adjacent healthy tissue.…”

Section: Introductionmentioning

confidence: 99%

<p>Molecular Antenna-Sensitized Upconversion Nanoparticle for Temperature Monitored Precision Photothermal Therapy</p>

Wei¹,

Liu²,

Pan³

et al. 2020

IJN

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Background: Photothermal therapy with accurate and real-time temperature detection is desired in clinic. Upconversion nanocrystals (UCNs) are candidate materials for simultaneous temperature detection and photothermal agents carrying. However, the weak luminescence and multiple laser excitations of UCNs limit their application in thermal therapy. Materials and Methods: NaYF 4 :Yb 3+ ,Er 3+ ,Nd 3+ , PL-PEG-NH 2 , IR-806 and folic acid are selected as structural components. A nanoprobe (NP) integrated with efficient photothermal conversion and sensitive temperature detection capabilities is synthesized for precise photothermal therapy. The probes are based on near-infrared upconversion nanocrystals doped with Yb, Er and Nd ions, which can be excited by 808 nm light. IR-806 dye molecules are modified on the surface as molecular antennas to strongly absorb near-infrared photons for energy transfer and conversion. Results: The results show that under an 808 nm laser irradiation upconversion luminescence of the nanocrystals is enhanced based on both the Nd ion absorption and the FRET energy transfer of IR-806. The luminescence ratio at 520 and 545 nm is calculated to accurately monitor the temperature of the nanoparticles. The temperature of the nanoprobes increases significantly through energy conversion of the molecular antennas. The nanoparticles are found successfully distributed to tumor cells and tumor tissue due to the modification of the biocompatible molecules on the surface. Tumor cells can be killed efficiently based on the photothermal effect of the NPs. Under the laser irradiation, temperature at mouse tumor site increases significantly, tissue necrosis and tumor cell death can be observed. Conclusion: Precision photothermal therapy can thus be achieved by highly efficient nearinfrared light absorption and accurate temperature monitoring, making it promising for tumor treatment, as well as the biological microzone temperature detection.

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Near-Infrared-Responsive Cancer Photothermal and Photodynamic Therapy Using Gold Nanoparticles

Cited by 189 publications

References 85 publications

Development of hydrophobic reduced graphene oxide as a new efficient approach for photochemotherapy

Development of hydrophobic reduced graphene oxide as a new efficient approach for photochemotherapy

Green Plasmonic Nanoparticles and Bio-Inspired Stimuli-Responsive Vesicles in Cancer Therapy Application

<p>Molecular Antenna-Sensitized Upconversion Nanoparticle for Temperature Monitored Precision Photothermal Therapy</p>

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