Near-infrared/pH dual-responsive nanocomplexes for targeted imaging and chemo/gene/photothermal tri-therapies of non-small cell lung cancer

Li, Ziying; Zhu, Lisheng; Liu, Weiqun; Zheng, Yilin; Li, Xudong; Ye, Jinxiang; Li, Bifei; Chen, Haijun; Gao, Yu

doi:10.1016/j.actbio.2020.03.004

Cited by 49 publications

(24 citation statements)

References 56 publications

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“…In addition, as a tyrosine kinase receptor, EGFR can be inhibited by corresponding small molecule inhibitors, such as getinib 47,48 and erlotinib. 49,50 Both monoclonal antibodies and inhibitors inhibit EGFR-mediated downstream signalling when providing targeting capabilities.…”

Section: "Intracellular Targets"mentioning

confidence: 99%

Dual-targeted photothermal agents for enhanced cancer therapy

et al. 2020

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Section: "Intracellular Targets"mentioning

confidence: 99%

Dual-targeted photothermal agents for enhanced cancer therapy

et al. 2020

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“…[31] It can be seen from Figure 4, the rapid release occurred in the initial few hours is mainly attributed to the NAT adsorbed on the surface of ICOP. [32] Subsequently, NAT released slowly from the inside of the ICOP. Noteworthily, NAT-ICOP composite presents an obvious pH-responsive drug release behavior.…”

Section: Resultsmentioning

confidence: 99%

Guanidinium‐Based Ionic Covalent Organic Porous Polymer as Natamycin Delivery Agents for Anti‐Candida albicans

et al. 2021

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Here, we have strategically prepared a biodegradable ionic covalent organic porous polymers (ICOP) with dynamic double selenium bond (SeÀ Se) which was further used as carriers for the antifungal drug-natamycin (NAT). ICOP presents a high drug-loading capability (DL) of 79.33 � 0.12 %, as well as high encapsulation efficiency (EE) of 76.75 � 0.58 % to NAT. Meanwhile, owning to the simultaneous introduction of À SeÀ SeÀ bond and imine linkage, the composite drug delivery system are responsive to pH, with selective and sustained release in acidic media (pH = 5.5), almost 1.34 fold as much as that in neutral conditions (pH = 7.4). This special drug release behavior is consisted well with the optimum growing environment of candida albicans (pH = 5.5), in which, more drugs could be released continuously, enhancing the duration of drug interactions with fungi and inhibiting the growth of fungus effectively. This novel dosing strategy is promising for the development of intelligent drug delivery system which could avoid the overdoses of drugs, and reduce the emergence of resistant strains.

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“…Targeted therapy that delivers drugs to cancer cells is important for improving treatment efficacy and avoiding systemic toxicity (Li et al, 2020;Shen et al, 2020). In recent years, the focus on developing targeted therapy with NP delivery systems has increased (Swain et al, 2016;Genchi et al, 2017;Adekiya et al, 2020).…”

Section: Discussionmentioning

confidence: 99%