Near-Infrared Optical Imaging of the Breast with Model-Based Reconstruction

Jiang, Huabei; Iftimia, Nicusor; Xu, Yong; Eggert, Julie; Fajardo, Laurie L.; Klove, K.

doi:10.1016/s1076-6332(03)80169-1

Cited by 120 publications

(85 citation statements)

References 32 publications

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“…[10][11][12][13][14] Most DOT breast imaging systems used fibers to deliver lasers to breast surface and collected the diffused light on the breast surface, in which the measurement number was determined by the optode pairings. 11,[15][16][17][18][19][20][21][22] To increase the number of measurement data, Culver et al reported a charge coupled device (CCD) camera based DOT imaging system. 23 Turner et al used a CCD camera to measure early photons in a DOT imaging system.…”

Section: Introductionmentioning

confidence: 99%

Diffuse optical tomography for breast cancer imaging guided by computed tomography: A feasibility study

Baikejiang

Zhang

2017

XST

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Abstract. Diffuse optical tomography (DOT) has attracted attentions in the last two decades due to its intrinsic sensitivity in imaging chromophores of tissues such as hemoglobin, water, and lipid. However, DOT has not been clinically accepted yet due to its low spatial resolution caused by strong optical scattering in tissues. Structural guidance provided by an anatomical imaging modality enhances the DOT imaging substantially. Here, we propose a computed tomography (CT) guided multispectral DOT imaging system for breast cancer imaging. To validate its feasibility, we have built a prototype DOT imaging system which consists of a laser at the wavelength of 650 nm and an electron multiplying charge coupled device (EMCCD) camera. We have validated the CT guided DOT reconstruction algorithms with numerical simulations and phantom experiments, in which different imaging setup parameters, such as projection number of measurements and width of measurement patch, have been investigated. Our results indicate that an air-cooling EMCCD camera is good enough for the transmission mode DOT imaging. We have also found that measurements at six angular projections are sufficient for DOT to reconstruct the optical targets with 2 and 4 times absorption contrast when the CT guidance is applied. Finally, we have described our future research plan on integration of a multispectral DOT imaging system into a breast CT scanner.

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Section: Introductionmentioning

confidence: 99%

Diffuse optical tomography for breast cancer imaging guided by computed tomography: A feasibility study

Baikejiang

Zhang

2017

XST

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“…Optical methods are currently being evaluated for use in breast cancer detection and monitoring. 29,30 The most significant limitation at this early date is spatial resolution and sensitivity to small lesions.…”

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confidence: 99%

Monitoring neoadjuvant chemotherapy in breast cancer using quantitative diffuse optical spectroscopy: a case study

et al. 2004

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Abstract. Presurgical chemotherapy is widely used in the treatment of locally advanced breast cancer. Monitoring the response to therapy can improve survival and reduce morbidity. We employ a noninvasive, near-infrared method based on diffuse optical spectroscopy (DOS) to quantitatively monitor tumor response to neoadjuvant chemotherapy. DOS was used to monitor tumor response in one patient with locally advanced breast cancer throughout the course of her therapy. Measurements were performed prior to doxorubicincyclophosphamide therapy and at several time points over the course of three treatment cycles (68 days). Our results show strong tumor to normal (T/N) tissue contrast in total hemoglobin concentration (T/N =2.4), water fraction (T/N=6.9), tissue hemoglobin oxygen saturation, S t O 2 (T/N=0.9), and lipid fraction (T/N=0.7) prior to treatment. Over a 10-week period, the peak total hemoglobin and water dropped 56 and 67%, respectively. Lipid content nearly returned to baseline (T/N ϭ0.9) while S t O 2 exceeded pretreatment levels (T/N =1.5). Approximately half of the hemoglobin and water changes occurred within 5 days of treatment (26 and 37%, respectively). These data suggest that noninvasive, quantitative optical methods that characterize tumor physiology may be useful in assessing and optimizing individual response to neoadjuvant chemotherapy. © 2004 Society of Photo-Optical Instrumentation Engineers.

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“…For example, because of the high optical absorption of haemoglobin (Hb), PAI can image blood vessels successfully [37]. Some in vivo studies showed that the ratio between the optical absorption contrasts of normal and tumour tissues in the breast can be as high as 1 : 3 in the NIR region owing to the greatly increased vascularity in the tumours [57][58][59]. Thus, in contrast to light scattering imaging, PAI requires the contrast agents to have high optical absorption.…”

Section: Photoacoustic Imaging Of Cancer Cellsmentioning

confidence: 99%

Cancer cell sensing and therapy using affinity tag-conjugated gold nanorods

et al. 2013

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Through the developments in controlling the shape of gold nanoparticles, synthesis of gold nanorods (AuNRs) can be considered as a milestone discovery in the area of nanomaterial-based cancer treatments. Besides having tuneable absorption maxima at near infrared (NIR) range, AuNRs have superior absorption cross section at NIR frequencies compared with other gold nanoparticles. When this unique optical property is combined with the specificity against cancer cells used by affinity tag conjugations, AuNRs become one of the most important nanoparticles used in both cancer cell sensing and in therapy. In this review, the impact of size and shape control of nanoparticles, especially AuNRs, on cancer cell treatments and a range of aptamer-conjugated AuNR applications in this regard are reviewed.

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Near-Infrared Optical Imaging of the Breast with Model-Based Reconstruction

Cited by 120 publications

References 32 publications

Diffuse optical tomography for breast cancer imaging guided by computed tomography: A feasibility study

Diffuse optical tomography for breast cancer imaging guided by computed tomography: A feasibility study

Monitoring neoadjuvant chemotherapy in breast cancer using quantitative diffuse optical spectroscopy: a case study

Cancer cell sensing and therapy using affinity tag-conjugated gold nanorods

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