Near-infrared light remote-controlled intracellular anti-cancer drug delivery using thermo/pH sensitive nanovehicle

Qin, Yanping; Chen, Jun; Bi, Ying; Xu, Xiaohan; Zhou, Hui; Gao, Jimin; Hu, Yi; Zhao, Yuliang; Chai, Zhifang

doi:10.1016/j.actbio.2015.01.026

Cited by 151 publications

(82 citation statements)

References 51 publications

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“…Suitable functional groups like chitosan may facilitate pH sensitivity. 146 The interaction of the loaded drug with components of the carrier can also impart pH responsiveness to the carrier. Wang et al 147 showed that the functional groups of DOX can bind to the amine and carboxyl groups of porous carbon nanocapsules, generating pH sensitivity, whereas the basic carbon structure of the carrier would absorb NIR energy and generate heat to release the drug.…”

Section: Light Activation As a Component Of Dual/multiresponsive Smentioning

confidence: 99%

Smart Nanostructures for Cargo Delivery: Uncaging and Activating by Light

et al. 2017

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Nanotechnology has begun to play a remarkable role in various fields of science and technology. In biomedical applications, nanoparticles have opened new horizons, especially for biosensing, targeted delivery of therapeutics, and so forth. Among drug delivery systems (DDSs), smart nanocarriers that respond to specific stimuli in their environment represent a growing field. Nanoplatforms that can be activated by an external application of light can be used for a wide variety of photoactivated therapies, especially light-triggered DDSs, relying on photoisomerization, photo-cross-linking/un-cross-linking, photoreduction, and so forth. In addition, light activation has potential in photodynamic therapy, photothermal therapy, radiotherapy, protected delivery of bioactive moieties, anticancer drug delivery systems, and theranostics (i.e., real-time monitoring and tracking combined with a therapeutic action to different diseases sites and organs). Combinations of these approaches can lead to enhanced and synergistic therapies, employing light as a trigger or for activation. Nonlinear light absorption mechanisms such as two-photon absorption and photon upconversion have been employed in the design of light-responsive DDSs. The integration of a light stimulus into dual/multiresponsive nanocarriers can provide spatiotemporal controlled delivery and release of therapeutic agents, targeted and controlled nanosystems, combined delivery of two or more agents, their on-demand release under specific conditions, and so forth. Overall, light-activated nanomedicines and DDSs are expected to provide more effective therapies against serious diseases such as cancers, inflammation, infections, and cardiovascular disease with reduced side effects and will open new doors toward the treatment of patients worldwide.

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Section: Light Activation As a Component Of Dual/multiresponsive Smentioning

confidence: 99%

Smart Nanostructures for Cargo Delivery: Uncaging and Activating by Light

et al. 2017

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“…Nanomedicine that uses laser or light irradiation can induce energy exchange for a temperature rise in the target region. Because of the non‐invasive and remote control ability, various light‐responsive nanomedicines have been developed in recent decades for controllable drug release under irradiation at a specific wavelength (Q. Feng et al, ; D. Li et al, ; Liu et al, ; Qin et al, ; Vankayala & Hwang, ; D. Wu, Xie, Kadi, & Zhang, ; X. Yang et al, ). The conventional light‐induced drug delivery system shows low penetration depth and strong scatter of soft tissue, due to the ultraviolet–visible light source.…”

Section: Physical‐responsive Nanomedicinementioning

confidence: 99%

Physical‐, chemical‐, and biological‐responsive nanomedicine for cancer therapy

Liao

Jia

et al. 2019

WIREs Nanomed Nanobiotechnol

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Cancer therapy is unsatisfactory as it typically has serious side effects, because normal cells in healthy organs are destroyed along with the tumor. Thus, researchers have tried to develop effective therapies with minimal side effects. One such method is to use nanotechnology to carry the drugs or therapeutic agents to the tumor region by secure encapsulation without leakage. Once the nanomedicine enters the target tumor site, it can release therapeutic agents in an effective manner. Accordingly, various nanomedicines have been developed to enhance the efficiency of cancer therapy and minimize the systematic toxicity. Here, we provide an overview and discuss the different types of responsive nanomedicines including physically, chemically, biologically, dual, and multi‐responsive nanomedicines, for the in situ release of cargos in recent years. We propose critical considerations that must be considered for the design of excellent stimuli‐nanomedicine. Furthermore, the possible directions for the development of successful stimuli‐responsive (smart) nanomedicine are highlighted. With the development of responsive nanomedicines, precise and personalized nanomedicine will be realized with great promise in the future. This article is categorized under: Therapeutic Approaches and Drug Discovery > Nanomedicine for Oncologic Disease Nanotechnology Approaches to Biology > Nanoscale Systems in Biology

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“…Moreover, apart from the gold‐related nanostructures for NIR light‐triggered drug release, a variety of nanostructures, including CuS nanoparticles, MoS 2 , carbon‐based nanomaterials, and some hybrid nanostructures or nanocomposites (e.g., Au‐Ag NPs, Fe 3 O 4 ‐Au NPs, FeCo/graphitic nanocrystals, and UCNPs‐Au composite nanomaterials), also demonstrated their promising photothermal properties for NIR light controlled drug delivery. For instance, Yang et al presented a new type of assembled Gd 2 O 3 :Yb/Er mesoporous silica UCNPs composites, which could demonstrate 2D hexagonal (MCM‐41‐Gd) and 3D cubical (MCM‐48‐Gd) network structures, respectively .…”

Section: Photoactivated Drug Delivery and Bioimaging Using Nir Light mentioning

confidence: 99%

Photoactivated drug delivery and bioimaging

Yang

Xing

2016

WIREs Nanomed Nanobiotechnol

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Among the various types of diseases, cancer remains one of the most leading causes of mortality that people are always suffering from and fighting with. So far, the effective cancer treatment demands accurate medical diagnosis, precise surgery, expensive medicine administration, which leads to a significant burden on patients, their families, and the whole national healthcare system around the world. In order to increase the therapeutic efficiency and minimize side effects in cancer treatment, various kinds of stimuli-responsive drug delivery systems and bioimaging platforms have been extensively developed within the past decades. Among them, the strategy of photoactivated approach has attracted considerable research interest because light enables the precise control, in a highly spatial and temporal manner, the release of drug molecules as well as the activation of bioimaging agents. In general, several appropriate photoresponsive systems, which are normally sensitive to ultraviolet (UV) or visible light irradiation to undergo the multiple reaction pathways such as photocleavage and photoisomerization strategy etc. have been mainly involved in the light activated cancer therapies. Considering the potential issues of poor tissue penetration and high photoctotoxicity of short wavelength light, the recently emerged therapies based on long-wavelength irradiation, e.g., near-infrared (NIR) light (700-1000 nm), have displayed distinct advantages in biomedical applications. The light irradiation at NIR window indicates minimized photodamage, deep penetration, and low autofluorescence in living cells and tissues, which are of clinical importance in the desired diagnosis and therapy. In this review article, we introduce the recent advances in light-activated drug release and biological imaging mainly for anticancer treatment. Various types of strategies such as photocage, photo-induced isomerization, optical upconversion, and photothermal release by which different wavelength ranges of light can play the important roles in the controlled therapeutic or imaging agents delivery, and activation will be systemically discussed. In addition, the challenges and future perspectives for photo-based cancer theranostics will be also summarized. WIREs Nanomed Nanobiotechnol 2017, 9:e1408. doi: 10.1002/wnan.1408 For further resources related to this article, please visit the WIREs website.

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Near-infrared light remote-controlled intracellular anti-cancer drug delivery using thermo/pH sensitive nanovehicle

Cited by 151 publications

References 51 publications

Smart Nanostructures for Cargo Delivery: Uncaging and Activating by Light

Smart Nanostructures for Cargo Delivery: Uncaging and Activating by Light

Physical‐, chemical‐, and biological‐responsive nanomedicine for cancer therapy

Photoactivated drug delivery and bioimaging

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