Near infrared light activatable PEI-wrapped bismuth selenide nanocomposites for photothermal/photodynamic therapy induced bacterial inactivation and dye degradation

Gorle, Govinda; Bathinapatla, Ayyappa; Chen, Yi-Zhan; Ling, Yong‐Chien

doi:10.1039/c8ra02183j

Cited by 28 publications

(20 citation statements)

References 44 publications

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“…13a2) were fabricated via a high-temperature reaction (colloidal synthesis) and their surface was coated with polyethyleneimine (PEI) through electrostatic interactions. 293 These NPs, at a concentration of 80 parts per million (ppm), were found to eradicate nearly 99% of S. aureus and around 97% of E. coli bacteria upon 10 min of NIR light irradiation through combined PTT and photodynamic therapy (PDT) via the generation of heat and ROS, respectively ( Fig. 13a3 and a4).…”

Section: Antimicrobial Activity Of Binps and Their Compositesmentioning

confidence: 99%

The versatile biomedical applications of bismuth-based nanoparticles and composites: therapeutic, diagnostic, biosensing, and regenerative properties

et al. 2020

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Studies of nanosized forms of bismuth (Bi)-containing materials have recently expanded from optical, chemical, electronic, and engineering fields towards biomedicine, as a result of their safety, cost-effective fabrication processes, large surface area, high stability, and high versatility in terms of shape, size, and porosity. Bi, as a nontoxic and inexpensive diamagnetic heavy metal, has been used for the fabrication of various nanoparticles (NPs) with unique structural, physicochemical, and compositional features to combine various properties, such as a favourably high X-ray attenuation coefficient and near-infrared (NIR) absorbance, excellent light-to-heat conversion efficiency, and a long circulation half-life. These features have rendered bismuth-containing nanoparticles (BiNPs) with desirable performance for combined cancer therapy, photothermal and radiation therapy (RT), multimodal imaging, theranostics, drug delivery, biosensing, and tissue engineering. Bismuth oxyhalides (BiO x , where X is Cl, Br or I) and bismuth chalcogenides, including bismuth oxide, bismuth sulfide, bismuth selenide, and bismuth telluride, have been heavily investigated for therapeutic purposes. The pharmacokinetics of these BiNPs can be easily improved via the facile modification of their surfaces with biocompatible polymers and proteins, resulting in enhanced colloidal stability, extended blood circulation, and reduced toxicity. Desirable antibacterial effects, bone regeneration potential, and tumor growth suppression under NIR laser radiation are the main biomedical research areas involving BiNPs that have opened up a new paradigm for their future clinical translation. This review emphasizes the synthesis and state-of-the-art progress related to the biomedical applications of BiNPs with different structures, sizes, and compositions. Furthermore, a comprehensive discussion focusing on challenges and future opportunities is presented.

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Section: Antimicrobial Activity Of Binps and Their Compositesmentioning

confidence: 99%

The versatile biomedical applications of bismuth-based nanoparticles and composites: therapeutic, diagnostic, biosensing, and regenerative properties

et al. 2020

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“…The average hydrodynamic diameter of bare CuS-BSA NPs was found to be 122 ± 8.8 nm ( Figure S6 ), with a surface charge of −18.6 ± 2.4 mV ( Figure S7 ), owing to the presence of hydroxyl and carboxyl groups in BSA [ 26 ]. After lysozyme loading, an average size of 158.2 nm and a surface charge of +7.13 ± 3.28 mV were recorded, indicating the successful adsorption of positively charged lysozyme onto a negatively charged CuS-BSA surface; the positive charge of CuS-BSA/lysozyme is favorable for attachment to the negatively charged bacterial surfaces [ 56 ]. The DLS size of the NPs is higher than that determined by TEM analysis owing to the hydration shell formed by water molecules on the nanoparticle’s surface [ 57 , 58 ].…”

Section: Resultsmentioning

confidence: 99%

Enhanced Antibacterial Activity of CuS-BSA/Lysozyme under Near Infrared Light Irradiation

et al. 2021

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The synthesis of multifunctional photothermal nanoagents for antibiotic loading and release remains a challenging task in nanomedicine. Herein, we investigated a simple, low-cost strategy for the preparation of CuS-BSA nanoparticles (NPs) loaded with a natural enzyme, lysozyme, as an antibacterial drug model under physiological conditions. The successful development of CuS-BSA NPs was confirmed by various characterization tools such as transmission electron microscopy (TEM), X-ray diffraction (XRD), Raman spectroscopy, and X-ray photoelectron spectroscopy (XPS). Lysozyme loading onto CuS-BSA NPs was evaluated by UV/vis absorption spectroscopy, Fourier-transform infrared spectroscopy (FTIR), zeta potential, and dynamic light scattering measurements. The CuS-BSA/lysozyme nanocomposite was investigated as an effective means for bacterial elimination of B. subtilis (Gram-positive) and E. coli (Gram-negative), owing to the combined photothermal heating performance of CuS-BSA and lysozyme release under 980 nm (0.7 W cm−2) illumination, which enhances the antibiotic action of the enzyme. Besides the photothermal properties, CuS-BSA/lysozyme nanocomposite possesses photodynamic activity induced by NIR illumination, which further improves its bacterial killing efficiency. The biocompatibility of CuS-BSA and CuS-BSA/Lysozyme was elicited in vitro on HeLa and U-87 MG cancer cell lines, and immortalized human hepatocyte (IHH) cell line. Considering these advantages, CuS-BSA NPs can be used as a suitable drug carrier and hold promise to overcome the limitations of traditional antibiotic therapy.

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“…In addition to the above-mentioned 2D NBG antibacterial nanomaterials, some other new members of 2D nanomaterials, such as layered double hydroxides (LDHs) 213-216, laponite (Lap) 217, 218, hexagonal boron nitride (BN) 176, III 2 -VI 3 compounds (In 2 Se 3 , Bi 2 Se 3 , Sb 2 Se 3 ) 90, 177, 219, 220, and RuO 2 have also been deemed as promising antibacterial agents. For example, Wang et al prepared various morphology of lysozyme modified LDHs through tuning the ratio of cations, and found that bloom flower structure of LDHs not only could load more lysozyme but also adhere to more bacteria, which show excellent antibacterial activity and wound healing ability 175.…”

Section: 2d Nbg Antibacterial Nanomaterialsmentioning

confidence: 99%

Two-dimensional nanomaterials beyond graphene for antibacterial applications: current progress and future perspectives

et al. 2020

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The marked augment of drug-resistance to traditional antibiotics underlines the crying need for novel replaceable antibacterials. Research advances have revealed the considerable sterilization potential of two-dimension graphene-based nanomaterials. Subsequently, two-dimensional nanomaterials beyond graphene (2D NBG) as novel antibacterials have also demonstrated their power for disinfection due to their unique physicochemical properties and good biocompatibility. Therefore, the exploration of antibacterial mechanisms of 2D NBG is vital to manipulate antibacterials for future applications. Herein, we summarize the recent research progress of 2D NBG-based antibacterial agents, starting with a detailed introduction of the relevant antibacterial mechanisms, including direct contact destruction, oxidative stress, photo-induced antibacterial, control drug/metallic ions releasing, and the multi-mode synergistic antibacterial. Then, the effect of the physicochemical properties of 2D NBG on their antibacterial activities is also discussed. Additionally, a summary of the different kinds of 2D NBG is given, such as transition-metal dichalcogenides/oxides, metal-based compounds, nitride-based nanomaterials, black phosphorus, transition metal carbides, and nitrides. Finally, we rationally analyze the current challenges and new perspectives for future study of more effective antibacterial agents. This review not only can help researchers grasp the current status of 2D NBG antibacterials, but also may catalyze breakthroughs in this fast-growing field.

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Near infrared light activatable PEI-wrapped bismuth selenide nanocomposites for photothermal/photodynamic therapy induced bacterial inactivation and dye degradation

Abstract: Inactivation of bacteria and degradation of organic pollutants by engineered nanomaterials (NMs) are very effective approaches in producing safe and clean drinking water.

Cited by 28 publications

References 44 publications

The versatile biomedical applications of bismuth-based nanoparticles and composites: therapeutic, diagnostic, biosensing, and regenerative properties

The versatile biomedical applications of bismuth-based nanoparticles and composites: therapeutic, diagnostic, biosensing, and regenerative properties

Enhanced Antibacterial Activity of CuS-BSA/Lysozyme under Near Infrared Light Irradiation

Two-dimensional nanomaterials beyond graphene for antibacterial applications: current progress and future perspectives

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