Near-infrared fluorescence probe: BSA-protected gold nanoclusters for the detection of metronidazole and related nitroimidazole derivatives

Meng, Lei; Yin, Jian‐Hang; Yuan, Yaqing; Xu, Na

doi:10.1039/c6ay03280j

Cited by 20 publications

(12 citation statements)

References 39 publications

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“…But these methods need expensive instruments, complicated operations and time‐consuming sample pretreatments, which greatly limit the detection efficiency of MTZ. However, it is worth noting that fluorescent chemosensors have been increasingly applied for the detection of MTZ with high sensitivity, selectivity, and facility . Among them, organic dyes and fluorescent metal nanoclusters are the chemosensors mainly used.…”

Section: Introductionmentioning

confidence: 99%

Detection of metronidazole in honey and metronidazole tablets using carbon dots‐based sensor via the inner filter effect

et al. 2018

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In this work, carbon dots (CDs) with a high quantum yield (22.3%) were easily prepared by hydrothermal pyrolysis of acid fuchsin 6B and hydrogen peroxide at 180°C for 10 h. The resultant CDs possess a narrow size distribution in the range of 2.6 to 3.2 nm and emit blue fluorescence. Interestingly, the absorption band of metronidazole (MTZ) centered at 318 nm can complementary overlap with the excitation band of the as-prepared CDs centered at 320 nm, resulting in an inner filter effect (IFE) in high efficiency. In fact, the fluorescence quenching of the CDs depends on the concentration of MTZ. Therefore, a simple method for the detection of MTZ can be established using the CDs-based sensor via the IFE. The linear range of the proposed method was 0-10 μg mL with the limit of detection as low as 0.257 μg mL . This CDs-based sensor had been applied for the detection of MTZ in honey and MTZ tablets with the recoveries in the range of 98.0% to 105.1% and 95.7% to 106.5%, respectively. Therefore, the as-prepared CDs have a potential to be developed as a MTZ sensor with high selectivity, sensitivity and accuracy.

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Section: Introductionmentioning

confidence: 99%

Detection of metronidazole in honey and metronidazole tablets using carbon dots‐based sensor via the inner filter effect

et al. 2018

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“…Deionized water (2.5 mL) and GE [various concentrations (0-222 mg mL −1 ) for optimization, 2.5 mL] were added into the aforementioned samples, which were then sonicated for an additional 30 s for the preparation of G-BSA-AuNCs. The final mixed samples of the sonicated solutions were transferred to microwave Teflon tubes, and the microwave oven was adjusted for different reaction temperatures (50, 60, 70, 80, and 90 • C) and different reaction times (5,8,10,12,15, and 20 min), according to an optimization process. The products obtained after the microwave reactions were purified through centrifugation in a 3 K centrifugal membrane at a speed of 8000 rpm for 25 min (with an interval time of 5 min).…”

Section: Preparation and Optimization Of The Mw_bsa-aunc And Mw_g-bsamentioning

confidence: 99%

“…We optimized the synthesis conditions. The final mixtures of sonicated solutions were transferred to microwave Teflon tubes for a microwave reaction at 70 • C (100 W) for different reaction times (5,8,10,12,15, and 20 min). The obtained products were purified.…”

Section: Optimization Of the Microwave Reaction Timementioning

confidence: 99%

“…However, some heavy metal components of QDs have been investigated for potential toxic effects in applications. Gold nanoclusters (AuNCs) have become popular for fluorescent probe applications because of their ultra-small size, easy preparation, and good photostability [8][9][10][11]. Bovine serum albumin (BSA)-modified AuNCs (BSA-AuNCs) have gained attention and popularity in applications of aqueous solutions due to their excellent biocompatibility and abundant functional groups [8][9][10].…”

Section: Introductionmentioning

confidence: 99%

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Microwave Synthesis of Gold Nanoclusters with Garlic Extract Modifications for the Simple and Sensitive Detection of Lead Ions

2020

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Novel bovine serum albumin (BSA)-gold nanoclusters with garlic extract modifications (mw_G-BSA-AuNCs) were prepared through microwave-assisted rapid synthesis. The modified nanoclusters were characterized and used for the simple and sensitive detection of Pb2+ ions. Both turn-on and turn-off methods were used and compared for Pb2+ ion detection. For Pb2+ ions, the preparation time for the modified nanoclusters was 10 min, and the detection time for the nanoclusters was 6 min. The modified nanoclusters were stable, and their fluorescence intensities changed by less than 10% in 60 days. The detection limit and linear range for the “off-on” method of mw_G-BSA-AuNCs for Pb2+ ion detection were 0.28 and 1–20 nM, respectively. The recoveries of the mw_G-BSA-AuNCs probe used for the detection of the Pb(II) ion in tap water ranged from 93.8% to 102.2%, with an average of 97.1%. The “off-on” method of mw_G-BSA-AuNCs can provide a lower detection limit, higher selectivity, and better recovery than the commonly used “turn-off” methods of mw_BSA-AuNCs for Pb2+ ion detection. The proposed method is superior to other methods proposed from 2018 to 2019 because it can provide a shorter preparation time and a lower detection limit with good selectivity. The microwave-assisted novel compound, mw_G-BSA-AuNCs, can be rapidly synthesized in a green manner and can provide a low detection limit, good selectivity, and a simple and fast reaction for Pb2+ ion detection.

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“…Recently, near-infrared (NIR) fluorescent probes have received much attention due to its advantages in deep tissue penetration, low background interference and minimal damage to cells and tissues [23–26]. While significant advances have been made towards detecting cellular targets or small molecules with near-IR probes [24–28], no such probes for Pb(II) detection in living cells were reported.…”

Section: Introductionmentioning

confidence: 99%

Near-infrared fluorescent probe for sensitive detection of Pb(II) ions in living cells

Fang

Wang

et al. 2017

Inorganica Chimica Acta

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A new near-infrared fluorescent probe (NIR-PbP) for sensitive detection of Pb(II) ions in solution and living cells has been rationally designed and synthesized. The NIR-PbP is inherently non-fluorescent and gains fluorescence in the presence Pb(II) ions. The ion detection is based on Pb(II)-induced unmasking the fluorophore through the opening of the spyrocycle, with more than 500-fold fluorescence for sub-micromolar Pb(II) concentration. The NIR-PbP has high sensitivity, good photo-stability, low detection limit, and reversible response to Pb(II) ions.

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Near-infrared fluorescence probe: BSA-protected gold nanoclusters for the detection of metronidazole and related nitroimidazole derivatives

Abstract: BSA-protected gold nanoclusters (AuNCs@BSA), as near infrared fluorescence probes, are synthesized to detect metronidazole (MTZ) and nitroimidazole derivatives, based on a photon-induced electron transfer (PET) process.

Cited by 20 publications

References 39 publications

Detection of metronidazole in honey and metronidazole tablets using carbon dots‐based sensor via the inner filter effect

Detection of metronidazole in honey and metronidazole tablets using carbon dots‐based sensor via the inner filter effect

Microwave Synthesis of Gold Nanoclusters with Garlic Extract Modifications for the Simple and Sensitive Detection of Lead Ions

Near-infrared fluorescent probe for sensitive detection of Pb(II) ions in living cells

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