Near-infrared-excited upconversion photodynamic therapy of extensively drug-resistantAcinetobacter baumanniibased on lanthanide nanoparticles

Abstract

<p>This work reports a novel strategy to combat extensively drug-resistant <italic>Acinetobacter baumannii via</italic> NIR-responsive UCNPs-based PDT.</p>

Which is Better for Nanomedicines: Nanocatalysts or Single‐Atom Catalysts?

“…•− , [217] which mainly occur in the bacterial cell membrane via hydrogen extraction with unsaturated phospholipid molecules. The phospholipid molecules further react with O 2 to form lipid peroxides, which destroy the structural integrity and increase the ionic permeability of bacterial biofilms.…”

“…Thus, the endogenous and exogenous trigger mechanisms will not be discussed here. The reaction of electron transport chain produces free radicals, such as •OH and O 2 •− , [ 217 ] which mainly occur in the bacterial cell membrane via hydrogen extraction with unsaturated phospholipid molecules. The phospholipid molecules further react with O 2 to form lipid peroxides, which destroy the structural integrity and increase the ionic permeability of bacterial biofilms.…”

A photo-sensitizable phage for multidrug-resistant Acinetobacter baumannii therapy and biofilm ablation

“…Photodynamic antimicrobial chemotherapy (PACT) has gained broad attention 9 and the use of many inorganic and metallic nanocomposites is the most researched strategy. 10,11 However such nanomaterials are difficult to degrade in vivo, which is the most fatal drawback for their practical application. [12][13][14] In contrast, organic small molecules have high biosafety owing to easy metabolism in vivo, and they hold great promise in PACT.…”

Mesoporous silica-coated gold nanorods loaded with tetrazolyl phthalocyanine as NIR light-activated nano-switches for synergistic photothermal and photodynamic inactivation of antibiotic-resistant Escherichia coli

“…20 Photodynamic therapy (PDT) against microbial cells is also considered to be an alternative high-efficiency strategy to eliminate bacteria both in vitro and in vivo. 13,21,22 The antibacterial strategy uses a specific wavelength of light to activate photosensitizers (PSs), which react with oxygen to produce reactive oxygen species (ROS) to kill bacteria. Phthalocyanines (Pcs) and metal phthalocyanines (MPcs) have been used as promising photosensitisers for PDT of cancerous and noncancerous diseases.…”