Near‐infrared chemiluminescent carbon nanogels for oncology imaging and therapy

Shen, Cheng‐Long; Jiang, Tianci; Lou, Qing; Zhao, Wenbo; Lv, Chunxiao; Zheng, Guang‐Song; Liu, Hangrui; Li, Pengfei; Dai, Lingling; Liu, Kaikai; Zang, Jinhao; Wang, Feng; Dong, Lin; Qu, Songnan; Cheng, Zhe; Shan, Chongxin

doi:10.1002/smm2.1099

Cited by 27 publications

(17 citation statements)

References 52 publications

(120 reference statements)

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“…Fluorescent nanocomposite hydrogels constructed by CDs and polymers have recently attracted much attention due to the extensive applications in the field of adsorption, [ 51 ] sensing, [ 52 ] bioimaging, [ 53 ] drug delivery, [ 54 ] and wound healing. [ 55 ] The long covalent chains of polymers give them a large number of reactive functional groups and provide excellent mechanical properties.…”

Section: Preparations and Gelation Mechanisms Of Cd‐based Hydrogelsmentioning

confidence: 99%

Carbon Dot‐Based Hydrogels: Preparations, Properties, and Applications

Wang

Yin

et al. 2023

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heat, electricity, magnetism, mechanics, and chemistry. For example, the involvement of nanoparticles has proved to be an effective strategy to impart multifunctional properties to the hydrogels. [11] As a composite material, nanoparticle hydrogel composites have made remarkable progress in the fields of biomedicine, [12,13] sensing, [14,15] advanced energy technology, [16] environment and industry. [17] For another example, fluorescent hydrogels have been constructed by introducing organic dyes, [18,19] lanthanides, [20,21] or semiconductor quantum dots [22] into the hydrogel system.CDs are a novel class of carbon-based nanomaterials, which can be viewed as the relatives of nanoparticles with contractible sizes (typically <10 nm). Compared with other nanoparticles, CDs have high photostability, [23] low cost, [24] good biocompatibility, [25] high water solubility, and tunable photoluminescence. [26] These intriguing properties afford CDs many potential applications in biomedicine, [27,28] sensing, [29,30] catalysis, [31,32] optoelectronic devices, [33][34][35] and anticounterfeiting. [36] The emergence of CDs solved the long-lasting drawbacks of traditional PL materials, such as the poor photostability of organic dyes, the high cost of lanthanides, and the toxicity of semiconductor quantum dots. Generally, CDs can be obtained by two strategies. One is the top-down route, in which the CDs are broken off from larger carbon species. The other is the bottomup route, in which the CDs are synthesized by using molecular precursors. [37] According to the micro-/nanostructure, formation mechanism, and precursors used, CDs are mainly divided into four categories: [38] graphene quantum dots (GQDs), carbon quantum dots (CQDs), carbon nanodots (CNDs), and carbonized polymer dots (CPDs). GQDs with one or multiple-layer graphite structure and apparent graphene lattices are generally gained by "top-down" prepared routes: oxidation of cutting bulky graphitized carbon materials. CQDs, CNDs, and CPDs are usually synthesized from biomass, small molecules, or polymers by assembling, polymerization, crosslinking, and carbonization by "bottom-up" routes. CQDs have graphitelike crystal lattices with surface functional groups, showing internal state luminescence and the quantum size confinement. CNDs also have a large number of functional groups on the surface, but the cores of CNDs contain amorphous carbon without apparent crystal lattices. [39] CPDs have unique "core-shell" nanostructures, consisting of carbon cores with Hydrogels have extremely high moisture content, which makes it very soft and excellently biocompatible. They have become an important soft material and have a wide range of applications in various fields such as biomedicine, bionic smart material, and electrochemistry. Carbon dot (CD)-based hydrogels are based on carbon dots (CDs) and auxiliary substances, forming a gel material with comprehensive properties of individual components. CDs embedding in hydrogels could not only solve their aggregation-caused quenching (A...

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Section: Preparations and Gelation Mechanisms Of Cd‐based Hydrogelsmentioning

confidence: 99%

Carbon Dot‐Based Hydrogels: Preparations, Properties, and Applications

Wang

Yin

et al. 2023

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“…[ 79 ] Finally, self‐assembled chemiluminescent carbonized polymer dots for highly biocompatible and self‐luminous carbon nanogel preparation with high detection sensitivity and specificity and superior imaging quality can also be utilized to provide efficient and excellent tools for biosensing and biomedical fields. [ 80 ]…”

Section: Properties Of Cdsmentioning

confidence: 99%

Deep‐Red to Near‐Infrared Carbon Dots in Biosensing and Bio‐medical Applications

Huang

Chen

et al. 2023

Chin. J. Chem.

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Comprehensive SummaryWith the rapid development in the field of biomedical diagnosis and treatment, carbon dots (CDs) with favorable photostability, biocompatibility and high quantum yields for deep‐red to near‐infrared emission have attracted the attention of a majority of researchers. By enlarging the sp2 domain in the core of CDs, doping them with heteroatoms like nitrogen and sulfur, applying hydrothermal, electrochemical, or microwave‐assisted techniques, CDs can be made with the aforementioned photoemission capabilities. In view of these excellent properties, CDs are flourishing in biosensing and biomedical applications, so that a thorough description and discussion of this topic is beneficial to capture the up‐to‐date progress of CDs in this field, providing suggestions and considerations for readers.

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“…With the previous report, the PL centers of the CNDs controlled by the π-conjugate system, which is formed with N heterocycles and aromatic rings, can provide deep-red emission with narrow FWHM. 25,47 Thereby, the corresponding energy level diagram of CNDs has been illustrated in Figure 5f. In the process, the CNDs have quite simple excited-state relaxation channels from the S 1 state to the ground state (S 0 state), leading to the high color purity deep-red emission.…”

Section: ■ Introductionmentioning

confidence: 99%

Biosynthesis of the Narrowband Deep-Red Emissive Carbon Nanodots from Eggshells

Deng

Shen

Zhao

et al. 2023

ACS Sustainable Chem. Eng.

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Safely recycling high-performance fluorescent materials from waste is an appealing route to reduce environmental pollution. This work presents one facile approach to massively producing high-performance carbon nanodots (CNDs) from discarded cooked eggshells. The obtained CND solution exhibits two excitation-independent deep-red emission peaks at 632 and 700 nm with a high photoluminescence quantum yield of 19.98% and a narrow full width at half-maximum (FWHM) of 16.2 nm. The deep-red emission of the CNDs originates from the porphyrin-like structure in the CNDs, which are formed in the eggshells and further carbonized by cooking. In addition, the deepred emission and unprecedented narrow FWHM of the CNDs deliver promising applications in bioimaging as an imaging agent. The recycled deep-red emissive CNDs pave a new strategy to design nanomaterials from biomass and provide a novel green pathway to recycle high-performance fluorescent nanomaterials sustainably.

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Near‐infrared chemiluminescent carbon nanogels for oncology imaging and therapy

Cited by 27 publications

References 52 publications

Carbon Dot‐Based Hydrogels: Preparations, Properties, and Applications

Carbon Dot‐Based Hydrogels: Preparations, Properties, and Applications

Deep‐Red to Near‐Infrared Carbon Dots in Biosensing and Bio‐medical Applications

Biosynthesis of the Narrowband Deep-Red Emissive Carbon Nanodots from Eggshells

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