Near-infrared-activated anticancer platinum(IV) complexes directly photooxidize biomolecules in an oxygen-independent manner

Bioorthogonal chemistry for prodrug activation in vivo

“…115 Recently, Zhu and coworkers developed near-infrared-activated carboplatin- and oxaliplatin-based Pt( iv ) photooxidants. 116 This validates the concept of metal-enhanced photooxidation in anti-metastatic tumours by directly damaging intracellular biomolecules and decreasing pHi.…”

A Multifunctional Covalent Organic Framework Nanozyme for Promoting Ferroptotic Radiotherapy against Esophageal Cancer

“…Similarly, NADH was also rapidly oxidized to nicotinamide adenine dinucleotide (NAD + ) in a concentration-dependent manner with the aid of TADI-COF-Fc , resulting in decreased absorbance at 340 nm and increased absorbance at 260 nm (Figure H) . High-resolution mass spectrometry (HRMS) further confirmed the conversion of NADH to NAD + (Figure I) . Michaelis–Menten kinetic analysis showed that the reaction rate was dependent on the concentration of H 2 O 2 (Figures J and S13), and Lineweaver–Burk fitting yielded a K m value of 22.67 mM (Figure K), confirming the NDH-like catalytic activity of TADI-COF-Fc .…”

“…93 High- resolution mass spectrometry (HRMS) further confirmed the conversion of NADH to NAD + (Figure 5I). 94 Michaelis− Menten kinetic analysis showed that the reaction rate was dependent on the concentration of H 2 O 2 (Figures 5J and S13), and Lineweaver−Burk fitting yielded a K m value of 22.67 mM (Figure 5K), confirming the NDH-like catalytic activity of TADI-COF-Fc. In Vitro Radiotherapy.…”

Ru(II) Phenanthroline-Based Oligothienyl Complexes as Phototherapy Agents

“…In addition, PDT can induce hypoxia as oxygen is consumed during irradiation. , Decreased generation of ROS limits damage to cancerous cells. To address this, there is motivation to develop light-triggered compounds that exploit oxygen-independent mechanisms for phototoxicity. − In this context, metal complexes such as Ru(II) polypyridyl systems have attracted considerable attention. ,,,− Judicious choice of ligand–metal combinations provides access to a variety of excited-state configurations with characteristic photophysical properties and reactivities. Strategies have included photorelease of bulky ligands to reveal phototoxic metals and/or ligands, ,,,,,− photocaging of chemotherapeutics and enzyme inhibitors, ,,,,,− …”