Bioorthogonal chemistry for prodrug activation <i>in vivo</i>

Fu, Qunfeng; Shen, Siyong; Sun, Pengwei; Gu, Zhi; Bai, Yifei; Wang, Xianglin; Liu, Zhibo

doi:10.1039/d2cs00889k

Cited by 21 publications

(7 citation statements)

References 210 publications

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“…The drug's pharmacological activity is concealed in the prodrug and is only restored in vivo after biotransformation is complete. 69 The concentration of carnosine in lenses decreased from approximately 25 μM to 5 μM during different stages of cataract development. 27 LCS, a dipeptide found naturally, has demonstrated potential in preventing and treating cataracts due to its antioxidant properties, ability to reduce glycosylation, and inhibition of protein degradation.…”

Section: Prodrugsmentioning

confidence: 97%

Breaking Barriers: Nanomedicine-Based Drug Delivery for Cataract Treatment

Chen,

Ye,

Chen

et al. 2024

IJN

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Cataract is a leading cause of blindness globally, and its surgical treatment poses a significant burden on global healthcare. Pharmacologic therapies, including antioxidants and protein aggregation reversal agents, have attracted great attention in the treatment of cataracts in recent years. Due to the anatomical and physiological barriers of the eye, the effectiveness of traditional eye drops for delivering drugs topically to the lens is hindered. The advancements in nanomedicine present novel and promising strategies for addressing challenges in drug delivery to the lens, including the development of nanoparticle formulations that can improve drug penetration into the anterior segment and enable sustained release of medications. This review introduces various cutting-edge drug delivery systems for cataract treatment, highlighting their physicochemical properties and surface engineering for optimal design, thus providing impetus for further innovative research and potential clinical applications of anti-cataract drugs.

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Section: Prodrugsmentioning

confidence: 97%

Breaking Barriers: Nanomedicine-Based Drug Delivery for Cataract Treatment

Chen,

Ye,

Chen

et al. 2024

IJN

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“…Additional desired features may also play a role. For example, the scope of click to release reactions is constantly expanding, with molecules that can release cargo or a quencher of their fluorescent moiety upon reaction completion [ 124 ]. So far, click to release has been reported from the Staudinger ligation [ 125 ], tetrazines [ 126 ], TCOs [ 127 , 128 ], VBAs [ 129 ], iminosydnones [ 39 , 40 ], and primary isonitriles [ 130 ].…”

Section: Considerations and Challenges In Mutual Bioorthogonal Chemistrymentioning

confidence: 99%

Mutually Orthogonal Bioorthogonal Reactions: Selective Chemistries for Labeling Multiple Biomolecules Simultaneously

Venrooij,

de Bondt,

Bonger

2024

Top Curr Chem (Z)

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Bioorthogonal click chemistry has played a transformative role in many research fields, including chemistry, biology, and medicine. Click reactions are crucial to produce increasingly complex bioconjugates, to visualize and manipulate biomolecules in living systems and for various applications in bioengineering and drug delivery. As biological (model) systems grow more complex, researchers have an increasing need for using multiple orthogonal click reactions simultaneously. In this review, we will introduce the most common bioorthogonal reactions and discuss their orthogonal use on the basis of their mechanism and electronic or steric tuning. We provide an overview of strategies to create reaction orthogonality and show recent examples of mutual orthogonal chemistry used for simultaneous biomolecule labeling. We end by discussing some considerations for the type of chemistry needed for labeling biomolecules in a system of choice.

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“…Bioorthogonal chemistry introduced new reactions that enable selective chemistry in such complex systems. 1–6…”

Section: Introductionmentioning

confidence: 99%

Discovery of new tetrazines for bioorthogonal reactions with strained alkenes via computational chemistry

Májek,

Trtúšek

2024

RSC Adv.

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Bioorthogonal chemistry for prodrug activation in vivo

Abstract: Bioorthogonal chemistry used in prodrug activation for cancer treatment and its potential for clinical translation.

Cited by 21 publications

References 210 publications

Breaking Barriers: Nanomedicine-Based Drug Delivery for Cataract Treatment

Breaking Barriers: Nanomedicine-Based Drug Delivery for Cataract Treatment

Mutually Orthogonal Bioorthogonal Reactions: Selective Chemistries for Labeling Multiple Biomolecules Simultaneously

Discovery of new tetrazines for bioorthogonal reactions with strained alkenes via computational chemistry

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