Near-infrared absorbing and luminescent gold speckled silica nanoparticles for photothermal therapy

Sharma, Prashant; Brown, Scott C.; Singh, Amit; Iwakuma, Nobutaka; Pyrgiotakis, Georgios; Krishna, Vijay; Knapik, Jacquelyn A.; Barr, Keira; Moudgil, Brij M.; Grobmyer, Stephen R.

doi:10.1039/c0jm00354a

Cited by 30 publications

(31 citation statements)

References 29 publications

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“…Numerous studies have demonstrated the efficacy of these nanomaterials for tumor ablation in vitro. 2,7,8,13 Several studies have focused on the effect of photothermal therapy using these nanomaterials using in vivo models. 1,10,13 These in vivo studies have demonstrated that a single photothermal treatment results in partial but incomplete tumor destruction based on long term follow-up of tumor growth.…”

Section: Introductionmentioning

confidence: 99%

“…6 Numerous nanomaterials including nanoshells, 1,2 polyhydroxy fullerenes, 5 gold speckled silica nanoparticles (NPs), 7 gold NPs, 8 gold nanorods, 3 nanotubes, 9,10 nanocages, 11 and quantum dots 12 have been investigated as anticancer photothermal agents. Numerous studies have demonstrated the efficacy of these nanomaterials for tumor ablation in vitro.…”

Section: Introductionmentioning

confidence: 99%

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Fractionated photothermal antitumor therapy with multidye nanoparticles

Gutwein¹,

Singh²,

Hahn³

et al. 2012

IJN

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Purpose: Photothermal therapy is an emerging cancer treatment paradigm which involves highly localized heating and killing of tumor cells, due to the presence of nanomaterials that can strongly absorb near-infrared (NIR) light. In addition to having deep penetration depths in tissue, NIR light is innocuous to normal cells. Little is known currently about the fate of nanomaterials post photothermal ablation and the implications thereof. The purpose of this investigation was to define the intratumoral fate of nanoparticles (NPs) after photothermal therapy in vivo and characterize the use of novel multidye theranostic NPs (MDT-NPs) for fractionated photothermal antitumor therapy. Methods: The photothermal and fluorescent properties of MDT-NPs were first characterized. To investigate the fate of nanomaterials following photothermal ablation in vivo, novel MDTNPs and a murine mammary tumor model were used. Intratumoral injection of MDT-NPs and real-time fluorescence imaging before and after fractionated photothermal therapy was performed to study the intratumoral fate of MDT-NPs. Gross tumor and histological changes were made comparing MDT-NP treated and control tumor-bearing mice. Results: The dual dye-loaded mesoporous NPs (ie, MDT-NPs; circa 100 nm) retained both their NIR absorbing and NIR fluorescent capabilities after photoactivation. In vivo MDT-NPs remained localized in the intratumoral position after photothermal ablation. With fractionated photothermal therapy, there was significant treatment effect observed macroscopically (P = 0.026) in experimental tumor-bearing mice compared to control treated tumor-bearing mice. Conclusion: Fractionated photothermal therapy for cancer represents a new therapeutic paradigm enabled by the application of novel functional nanomaterials. MDT-NPs may advance clinical treatment of cancer by enabling fractionated real-time image guided photothermal therapy.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Fractionated photothermal antitumor therapy with multidye nanoparticles

Gutwein¹,

Singh²,

Hahn³

et al. 2012

IJN

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“…For breast cancer, intratumoral delivery could involve direct intratumoral injection of nanoparticles guided by traditional imaging [ultrasound, magnetic resonance imaging (MRI), or mammography] 10. Advantages of this approach are restricted exposure of delivered nanomaterials to diseased sites.…”

Section: Delivering Nanomaterials To Breast Cancer Sitesmentioning

confidence: 99%

“…A number of nanomaterials are active photothermal agents including gold speckled silica nanoparticles, nanoshells, nanorods, nanocages, and nanotubes 2. Sharma et al 10 have recently demonstrated the efficacy of gold speckled silica nanoparticles as multifunctional photothermal cancer agents in a murine model of breast cancer (Fig. 1).…”

Section: Non‐invasive Treatment Of Breast Cancermentioning

confidence: 99%

The promise of nanotechnology for solving clinical problems in breast cancer

Grobmyer

Morse

Fletcher

et al. 2011

Journal of Surgical Oncology

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Approaches for breast cancer treatment are invasive, disfiguring, have significant side-effects, and are not always curative. Nanotechnology is an emerging area which is focused on engineering of materials <100 × 10(-9) m. There is significant promise for advancing nanotechnology to improve breast cancer diagnosis and treatment including non-invasive therapy, monitoring response to therapy, advanced imaging, treatment of metastatic disease, and improved nodal staging. Current approaches and important future directions are discussed.

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“…7,8 Therefore a facile route to synthesize nanosized metallic particles has become highly desirable. 22,35,[46][47][48] Inspired by these considerations, this work aims to synthesize silica nanotube (SNT)-supported noble metallic nanoparticles (i.e., Au, Ag, and Pd) under ambitious conditions and explore their catalytic activity in the reaction of 4-nitrophenol reduction by sodium borohydride. As the particle size is reduced, the surface energy of nanoparticles increases, making them unstable with high tendency for inter-particle aggregation.…”

Section: Introductionmentioning

confidence: 99%

Self-assembled laminated nanoribbon-directed synthesis of noble metallic nanoparticle-decorated silica nanotubes and their catalytic applications

et al. 2012

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Substrate-supported noble metallic nanoparticles have received intense attention owing to their great potential in various applications. In this work, silica nanotube-supported metallic nanoparticles (i.e., Au, Ag, and Pd) are synthesized by in situ reducing metal ions into nanoparticles on the nanotube surface. The silica nanotubes are prepared through the traditional sol-gel approach using laminated nanoribbons as soft templates, which are self-assembled from dipeptide-amphiphiles. The surface of silica nanotubes is functionalized to display amino groups, which serve as active sites to host metallic particles. By changing the preparation conditions, the wall thickness of silica nanotubes is adjusted and the density of metallic nanoparticles on silica surface is facilely tuned. Finally the metallic nanoparticlecoated silica nanotubes are proven to be applicable in recyclable catalysis of 4-nitrophenol (4-NP) reduction.

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Near-infrared absorbing and luminescent gold speckled silica nanoparticles for photothermal therapy

Cited by 30 publications

References 29 publications

Fractionated photothermal antitumor therapy with multidye nanoparticles

Fractionated photothermal antitumor therapy with multidye nanoparticles

The promise of nanotechnology for solving clinical problems in breast cancer

Self-assembled laminated nanoribbon-directed synthesis of noble metallic nanoparticle-decorated silica nanotubes and their catalytic applications

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