The promise of nanotechnology for solving clinical problems in breast cancer

Grobmyer, Stephen R.; Morse, David L.; Fletcher, Bradley S.; Gutwein, Luke G.; Sharma, Prashant; Krishna, Vijay; Frost, Susan C.; Moudgil, Brij M.; Brown, Scott C.

doi:10.1002/jso.21698

Cited by 32 publications

(12 citation statements)

References 97 publications

(107 reference statements)

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“…Breast cancer is the most common invasive cancer worldwide and for triple negative breast cancer, no targeted effective therapy is available till date 1 , 2 . Resistance to anticancer drugs and their side effects are the major hurdles in the treatment of TNBC.…”

Section: Introductionmentioning

confidence: 99%

Gold nanoparticles-induced cytotoxicity in triple negative breast cancer involves different epigenetic alterations depending upon the surface charge

Surapaneni

Bashir

Tikoo

2018

Sci Rep

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Gold nanoparticles (AuNPs) are used enormously in different cancers but very little is known regarding their molecular mechanism and surface charge role in the process of cell death. Here, we elucidate the molecular mechanism by which differentially charged AuNPs induce cytotoxicity in triple negative breast cancer (TNBC) cells. Cytotoxicity assay revealed that both negatively charged (citrate-capped) and positively charged (cysteamine-capped) AuNPs induced cell-death in a dose-dependent manner. We provide first evidence that AuNPs-induced oxidative stress alters Wnt signalling pathway in MDA-MB-231 and MDA-MB-468 cells. Although both differentially charged AuNPs induced cell death, the rate and mechanism involved in the process of cell death were different. Negatively charged AuNPs increased the expression of MKP-1, dephosphorylated and deacetylated histone H3 at Ser10 and K9/K14 residues respectively whereas, positively charged AuNPs decreased the expression of MKP-1, phosphorylated and acetylated histone H3 at Ser 10 and K9/K14 residues respectively. High-resolution transmission electron microscopy (HRTEM) studies revealed that AuNPs were localised in cytoplasm and mitochondria of MDA-MB-231 cells. Interestingly, AuNPs treatment makes MDA-MB-231 cells sensitive to 5-fluorouracil (5-FU) by decreasing the expression of thymidylate synthetase enzyme. This study highlights the role of surface charge (independent of size) in the mechanisms of toxicity and cell death.

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Section: Introductionmentioning

confidence: 99%

Gold nanoparticles-induced cytotoxicity in triple negative breast cancer involves different epigenetic alterations depending upon the surface charge

Surapaneni

Bashir

Tikoo

2018

Sci Rep

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“…3 Preliminary evidence indicates the potential of nanoparticles to cross biological barriers and cause adverse health effects. 4 On a positive note, nanoparticle-based theranostics 5 are one of the most promising applications that can help shape the way diseases 6 are diagnosed and treated 7 by MRI, 8 X-Rays, 9 and Photo Acoustic Tomography (PAT). 10 Both the potential adverse effects and the theranostics efficacy are directly related to the nanoparticle uptake from the cells.…”

Section: Introductionmentioning

confidence: 99%

Nanoparticle–Nanoparticle Interactions in Biological Media by Atomic Force Microscopy

et al. 2013

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Particle-particle interactions in physiological media are important determinants for nanoparticle fate and transport. Herein, such interactions are assessed by a novel Atomic Force Microscopy (AFM) based platform. Industry-relevant CeO2, Fe2O3, and SiO2 nanoparticles of various diameters were made by the flame spray pyrolysis (FSP) based Harvard Versatile Engineering Nanomaterials Generation System (Harvard VENGES). The nanoparticles were fully characterized structurally and morphologically and their properties in water and biological media were also assessed. The nanoparticles were attached on AFM tips and deposited on Si substrates to measure particle–particle interactions. The corresponding force was measured in air, water and biological media that are widely used in toxicological studies. The presented AFM based approach can be used to assess the agglomeration potential of nanoparticles in physiological fluids. The agglomeration potential of CeO2 nanoparticles in water and RPMI 1640 (Roswell Park Memorial Institute formulation 1640) was inversely proportional to their primary particle (PP) diameter, but for Fe2O3 nanoparticles, that potential is independent of PP diameter in these media. Moreover, in RPMI+10% Fetal Bovine Serum (FBS) the corona thickness and dispersibility of the CeO2 is independent of PP diameter while for Fe2O3, the corona thickness and dispersibility were inversely proportional to PP diameter. The present method can be combined with (dynamic light scattering (DLS), proteomics, and computer simulations to understand the nano-bio interactions, with emphasis on the agglomeration potential of nanoparticles and their transport in physiological media.

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“…Nanotechnology has potential to revolutionize cancer diagnosis and therapy comprising non-invasive therapy, advanced imaging, monitoring response to therapy, improved nodal staging and treatment of metastatic disease [5]. Nanotechnology may modify pharmaco-kinetics and delivery refining effectiveness and lessening side effects [23,24]. The size and surface properties enrich drug portability, mobility, flexibility and thus enhance choosy internment in tumour tissue making them potentially operative tumour conveyance vectors [25].…”

Section: Nanotechnology In Targeted Drug Deliverymentioning

confidence: 99%

Nanomaterials as nanocarriers: a critical assessment why these are multi-chore vanquisher in breast cancer treatment

Naz

Shahzad

Ali

et al. 2017

Artificial Cells, Nanomedicine, and Biotechnology

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Breast cancer is a group of diseases with various subtypes and leads to high mortality throughout the globe. Various conventional techniques are in practice to cure breast cancer but these techniques are linked with various shortcomings. Mostly these treatments are not site directed and cause toxicity towards normal cells. In order to overcome these issues, we need smart system that can deliver anticancer drugs to specific sites. Targeted drug delivery can be achieved via passive or active drug delivery using nanocarriers. This mode of drug delivery is more effective against breast cancer and may help in the reduction of mortality rate. Potentially used nanocarriers for targeted drug delivery belong to organic and inorganic molecules. Various FDA approved nano products are in use to cure breast cancer. However, body's defense system is main limitation for potential use of nano systems. However, this can be overcome by surface modification of nanocarriers. In this review, breast cancer and its types, targeted drug delivery and nanocarriers used to cure breast cancer are discussed. By progressing nanotechnology, we will be able to fight against this life threatening issue and serve the humanity, which is the basic aim of scientific knowledge.

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The promise of nanotechnology for solving clinical problems in breast cancer

Cited by 32 publications

References 97 publications

Gold nanoparticles-induced cytotoxicity in triple negative breast cancer involves different epigenetic alterations depending upon the surface charge

Gold nanoparticles-induced cytotoxicity in triple negative breast cancer involves different epigenetic alterations depending upon the surface charge

Nanoparticle–Nanoparticle Interactions in Biological Media by Atomic Force Microscopy

Nanomaterials as nanocarriers: a critical assessment why these are multi-chore vanquisher in breast cancer treatment

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