NDM-1- and OXA-23-producing Acinetobacter baumannii isolated from intensive care unit patients in Tunisia

Maamar, Elaa; Alonso, Carla Andrea; Ferjani, Sana; Jendoubi, Ali; Hamzaoui, Zaineb; Jebri, Alia; Saïdani, Mabrouka; Ghedira, S.; Torres, Carmén; Boubaker, Ilhem Boutiba-Ben

doi:10.1016/j.ijantimicag.2018.04.008

Cited by 25 publications

(14 citation statements)

References 34 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Further genome sequence analysis of ST451 in 2019, there was only one copy of TEM-1 in the MDR A. baumannii isolates in the study, indicating the specific molecular mechanism of the resistance of A. baumannii to cefoperazone-sulbactam might be diversity. As an important resistance gene of A. baumannii, only one isolate carried bla NDM−1 in 2010-2011, however, given its distribution worldwide, enhanced monitoring is needed (20,21). In addition, A. baumannii isolates carried several aminoglycoside-resistant genes and gene for 16s rRNA methylation enzymes, of which ant(3")-I and armA could be detected every year.…”

Section: Discussionmentioning

confidence: 99%

Epidemiological Analysis of Multidrug-Resistant Acinetobacter baumannii Isolates in a Tertiary Hospital Over a 12-Year Period in China

Jiang

Chen

Liu

et al. 2021

Front. Public Health

View full text Add to dashboard Cite

Acinetobacter baumannii is an important nosocomial pathogen, which is multidrug resistant (MDR). Acinetobacter baumannii has become a major threat to public health worldwide due to its ability to easily acquire resistant genes. In order to analyze its epidemiology characteristics and the genetic evolution, A. baumannii isolates obtained from a Chinese tertiary hospital in the past 12 years (2008–2019), 295 isolates of non-repetitive A. baumannii, were recovered from patients and wards environments. The resistance genes were analyzed using antimicrobial susceptibility testing. The genetic relatedness of 295 isolates was identified by multilocus sequence typing (MLST) and eBURST analysis. It was found that the antibiotic-resistant and carbapenemase-resistant genes of all the 295 MDR A. baumannii in the hospital have not changed significantly over the past 12 years; all of them were resistant to multiple antibiotics except the polymyxin E and tigecycline. The results of drug-resistant genes showed that the detection rates of carbapenemase-resistant genes blaOXA−23, blaTEM−1, and blaOXA−66 were 97.6, 75.3, and 71.9%, respectively, which were detected almost every year from 2008 to 2019. Additionally, 16s rRNA methylation enzyme gene armA, aminoglycoside-resistant gene ant(3")-I, and class I integrase gene could also have a high positive rate. By MLST, these isolates were assigned to 12 sequence types (STs), including ST369, ST208, ST195, ST191, ST368, ST530, ST469, ST451, ST229, ST381, ST543, and ST1176. eBURST analysis showed that 9 STs with ST208 as the founder genotype belonged to Group 1 except for ST229, ST530, and ST1176. Therefore, most MDR A. baumannii isolates had a relatively close genetic relationship. Notably, the predominant ST208 and ST369 at the early stage changed to ST451 in 2019, indicating that the complex and diverse genetic background of the prevalence of A. baumannii isolates in the hospital. Overall, further epidemiological surveillance and genetic evolution analysis of A. baumannii are required, which can provide new strategies for the prevention and control of A. baumannii infections.

show abstract

Section: Discussionmentioning

confidence: 99%

Epidemiological Analysis of Multidrug-Resistant Acinetobacter baumannii Isolates in a Tertiary Hospital Over a 12-Year Period in China

Jiang

Chen

Liu

et al. 2021

Front. Public Health

View full text Add to dashboard Cite

show abstract

“…The carbapenemases belonging to the groups OXA-23, OXA-24/40, OXA-58, and OXA-143are frequently observed among A . baumannii clinical isolates[4]. The genes encoding for such enzymes are generally associated with mobile genetic elements, such as insertion sequences (IS) that lead to their mobilization for other A .…”

Section: Introductionmentioning

confidence: 99%

A high mortality rate associated with multidrug-resistant Acinetobacter baumannii ST79 and ST25 carrying OXA-23 in a Brazilian intensive care unit

et al. 2018

View full text Add to dashboard Cite

The global spread of carbapenem-resistant Acinetobacter baumannii (A. baumannii) strains has restricted the therapeutic options available to treat infections due to this pathogen. Understanding the prevalence of such infections and the underlying genetic mechanisms of resistance may help in the implementation of adequate measures to control and prevent acquisition of nosocomial infections, especially in an intensive care unit setting. This study describes the molecular characteristics and risk factors associated with OXA-23-producing A. baumannii infections. A case-control study was undertaken from September/2013 to April/2015. Acquisition of OXA-23-producing A. baumannii was found to be associated with the use of nasogastric tubes, haemodialysis, and the use of cephalosporins. These isolates were only susceptible to amikacin, gentamicin, tigecycline, and colistin, and contained the ISAba1 insertion sequence upstream ofblaOXA-23 and blaOXA-51 genes. Twenty-six OXA-23-producing A. baumannii strains belonged to the ST79 (CC79) clonal group,and patients infected or colonised by these isolates had a higher mortality rate (34.6%). In conclusion, this study showed a dissemination of OXA-23-producing A. baumannii strains that was associated with several healthcare-related risk factors and high mortality rates among intensive care unit patients.

show abstract

“…In this context, Hamzaoui et al describe the role of association of OmpK35 and OmpK36 alteration and bla ESBL and/or bla AmpC in conferring carbapenem resistance among non-carbapenemase-producing Klebsiella pneumoniae [5] . The most recent metallo-β-lactamase, NDM-1, is particularly described in this Special Issue by Kanzari et al who describe the first report of an extensively drug-resistant Proteus mirabilis isolate carrying plasmid-mediated bla NDM-1 [6] and by Maamar et al who describe the incidence of NDM-1-and OXA-23 among clinical isolates of Acinetobacter baumannii [7] . In addition, Jaidane et al present a metagenomic analysis of the whole genome of NDM-1-producing ST85 A. baumannii isolates from Tunisia.…”

Section: Recent Advances In Antimicrobial and Bacterial Resistancementioning

confidence: 99%

Recent advances in antimicrobial and bacterial resistance

Chouchani¹,

Rolain

Ghrairi

2018

International Journal of Antimicrobial Agents

View full text Add to dashboard Cite

HAL is a multidisciplinary open access archive for the deposit and dissemination of scientific research documents, whether they are published or not. The documents may come from teaching and research institutions in France or abroad, or from public or private research centers. L'archive ouverte pluridisciplinaire HAL, est destinée au dépôt et à la diffusion de documents scientifiques de niveau recherche, publiés ou non, émanant des établissements d'enseignement et de recherche français ou étrangers, des laboratoires publics ou privés.

show abstract

NDM-1- and OXA-23-producing Acinetobacter baumannii isolated from intensive care unit patients in Tunisia

Cited by 25 publications

References 34 publications

Epidemiological Analysis of Multidrug-Resistant Acinetobacter baumannii Isolates in a Tertiary Hospital Over a 12-Year Period in China

Epidemiological Analysis of Multidrug-Resistant Acinetobacter baumannii Isolates in a Tertiary Hospital Over a 12-Year Period in China

A high mortality rate associated with multidrug-resistant Acinetobacter baumannii ST79 and ST25 carrying OXA-23 in a Brazilian intensive care unit

Recent advances in antimicrobial and bacterial resistance

Contact Info

Product

Resources

About