Recent advances in antimicrobial and bacterial resistance

Chouchani, Chedly; Rolain, Jean‐Marc; Ghrairi, Taoufik

doi:10.1016/j.ijantimicag.2018.11.021

Cited by 7 publications

(4 citation statements)

References 13 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The ubiquitous foodborne pathogen-Bacillus cereus, which contaminates a range of edible products, including our-based items and dairy products, poses a signi cant health threat to both adults and children [2]. Research has elucidated that this bacterial species is ubiquitous in diverse environments, such as soil, water, air, and food matrices, existing in various forms, including vegetative cells, endospores, and bio lms [3,4].…”

Section: Introductionmentioning

confidence: 99%

Towards new bioactive fluorine-containing 1,3,4-oxadiazole-amide derivatives: Synthesis, antibacterial activity, molecular docking and molecular dynamics simulation study

Xiong,

Zhang,

Jiao

et al. 2024

Preprint

View full text Add to dashboard Cite

Through the approach of molecular hybridization, this study rationally designed and synthesized new trifluoromethyl-1,3,4-oxadiazole amide derivatives, denoted as 1a-1n. The findings reveal that these novel molecules exhibit potent inhibitory effects against various bacterial strains. Thereinto, compounds 1c, 1d, 1i, 1j and 1n, demonstrate relatively superior antimicrobial performance against B. cereus FM314, with a minimum inhibitory concentration (MIC) of 0.03907 µg/mL. Molecular docking analysis suggests the potential importance of the Ser57 and Thr125 amino acid residues in contributing to the inhibitory activity against B. cereus. The consistency of these results was further corroborated through subsequent molecular dynamics simulations and MMPBSA validations. The insights gained from this study serve to facilitate the rational design and efficient development of novel eco-friendly antimicrobial inhibitors based on the trifluoromethyl-1,3,4-oxadiazole amide scaffold.

show abstract

Section: Introductionmentioning

confidence: 99%

Towards new bioactive fluorine-containing 1,3,4-oxadiazole-amide derivatives: Synthesis, antibacterial activity, molecular docking and molecular dynamics simulation study

Xiong,

Zhang,

Jiao

et al. 2024

Preprint

View full text Add to dashboard Cite

show abstract

“…The unsatisfactory result in combating MDR could mean a literal return to pre-antibiotic era for many infections [ 3 ]. Countries already started protocols to prevent further spread of resistant bacterial strains, with non-consistent results [ 4 ]. The alarming rate of MDR made it obligatory to search for new approaches to combat MDR [ 5 ].…”

Section: Introductionmentioning

confidence: 99%

A Metagenomic Nanopore Sequence Analysis Combined with Conventional Screening and Spectroscopic Methods for Deciphering the Antimicrobial Metabolites Produced by Alcaligenes faecalis Soil Isolate MZ921504

Eltokhy

Saad²,

Eltayeb

et al. 2021

Antibiotics

View full text Add to dashboard Cite

The continuous development of multidrug resistance pathogens with limited therapeutic options has become a great problem globally that impose sever health hazards. Accordingly, searching for of new antimicrobials became an urgent demand and great challenge. Soil significantly have been associated with several species that are antibiotic producers. In this study, combination of conventional screening methods with Liquid chromatography- Mass spectroscopy (LC/MS) and metagenomic nanopore sequence analysis have been conducted for the deciphering the active metabolites produced by soil isolate(s). Preliminary soil screening resulted in a Gram-negative isolate identified via 16S ribosomal RNA as Alcaligenes faecalis isolate MZ921504 with promising antimicrobial activities against wide range of MDR gram-positive and gram-negative pathogens. The LC/MS analysis of the metabolites of A. faecalis isolate MZ921504 confirmed the presence of ectoine, bacillibactin, quinolobactin and burkholderic acid. Metagenomics sequence analysis of the soil sample (NCBI GenBank accession PRJNA771993) revealed the presence of conserved biosynthetic gene clusters of ectoine, bacteriocin, bacillibactin, quinolobactin, terpene and burkholderic acid of A. faecalis. In conclusion, A. faecalis isolate MZ921504 is a promising source for antimicrobial metabolites. LC/MS spectral analysis and third generation sequencing tools followed by secondary metabolite gene clusters analysis are useful methods to predict the nature of the antimicrobial metabolites.

show abstract

“…MDR is not just a national problem but a very complex global phenomenon. 1 Biofilms play an important role in infection caused by MDR bacteria: they are communities of surface attachment formed by microorganisms. 2 It produces an extracellular matrix that protects microbes from drugs and host immunity leading to persistent infections.…”

Section: Introductionmentioning

confidence: 99%

Coating CoCrMo Alloy with Graphene Oxide and ϵ-Poly-L-Lysine Enhances Its Antibacterial and Antibiofilm Properties

Guo¹,

Cao²,

Wang³

et al. 2021

IJN

View full text Add to dashboard Cite

Introduction:With increases in implant infections, the search for antibacterial and biofilm coatings has become a new interest for orthopaedists and dentists. In recent years, graphene oxide (GO) has been extensively studied for its superior antibacterial properties. However, most of these studies have focused on solutions and there are few antibacterial studies on metal surfaces, especially the surfaces of cobalt-chromium-molybdenum (CoCrMo) alloys. ε-Poly -L-lysine (ε-PLL), as a novel food preservative, has a spectrum of antimicrobial activity; however, its antimicrobial activity after coating an implant surface is not clear. Methods: In this study, for the first time, a two-step electrodeposition method was used to coat GO and ε-PLL on the surface of a CoCrMo alloy. Its antibacterial and antibiofilm properties against S. aureus and E. coli were then studied. Results:The results show that the formation of bacteria and biofilms on the coating surface was significantly inhibited, GO and ε-PLL composite coatings had the best antibacterial and antibiofilm effects, followed by ε-PLL and GO coatings. In terms of classification, the coatings are antiadhesive and contact-killing/inhibitory surfaces. In addition to oxidative stress, physical damage to GO and electrostatic osmosis of ε-PLL are the main antibacterial and antibiofilm mechanisms. Discussion: This is the first study that GO and ε-PLL coatings were successfully prepared on the surface of CoCrMo alloy by electrodeposition. It provides a promising new approach to the problem of implant infection in orthopedics and stomatology.

show abstract

Recent advances in antimicrobial and bacterial resistance

Cited by 7 publications

References 13 publications

Towards new bioactive fluorine-containing 1,3,4-oxadiazole-amide derivatives: Synthesis, antibacterial activity, molecular docking and molecular dynamics simulation study

Towards new bioactive fluorine-containing 1,3,4-oxadiazole-amide derivatives: Synthesis, antibacterial activity, molecular docking and molecular dynamics simulation study

A Metagenomic Nanopore Sequence Analysis Combined with Conventional Screening and Spectroscopic Methods for Deciphering the Antimicrobial Metabolites Produced by Alcaligenes faecalis Soil Isolate MZ921504

Coating CoCrMo Alloy with Graphene Oxide and ϵ-Poly-L-Lysine Enhances Its Antibacterial and Antibiofilm Properties

Contact Info

Product

Resources

About