Nd:YAG laser irradiation in conjunction with cryogen spray cooling induces deep and spatially selective photocoagulation in animal models

Anvari, Bahman; Tanenbaum, B. Samuel; Hoffman, Wendy B.; Said, Samireh; Milner, Thomas E.; Liaw, Lih‐Huei L.; Nelson, J. Stuart

doi:10.1088/0031-9155/42/2/001

Cited by 34 publications

(19 citation statements)

References 27 publications

(28 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The cooling mechanism removes heat from the probe-tissue interface and minimizes carbonization or vaporization and allows for creation of larger treated volumes. 1,38 The cooled probe surface further minimizes probe adherence to treated tissues and decreases the incidence of probe failure.…”

Section: Litt Probesmentioning

confidence: 99%

Renaissance of laser interstitial thermal ablation

Missios

Bekelis

Barnett

2015

FOC

162

124

View full text Add to dashboard Cite

Laser interstitial thermal therapy (LITT) is a minimally invasive technique for treating intracranial tumors, originally introduced in 1983. Its use in neurosurgical procedures was historically limited by early technical difficulties related to the monitoring and control of the extent of thermal damage. The development of magnetic resonance thermography and its application to LITT have allowed for real-time thermal imaging and feedback control during laser energy delivery, allowing for precise and accurate provision of tissue hyperthermia. Improvements in laser probe design, surgical stereotactic targeting hardware, and computer monitoring software have accelerated acceptance and clinical utilization of LITT as a neurosurgical treatment alternative. Current commercially available LITT systems have been used for the treatment of neurosurgical soft-tissue lesions, including difficult to access brain tumors, malignant gliomas, and radiosurgery-resistant metastases, as well as for the ablation of such lesions as epileptogenic foci and radiation necrosis. In this review, the authors aim to critically analyze the literature to describe the advent of LITT as a neurosurgical, laser excision tool, including its development, use, indications, and efficacy as it relates to neurosurgical applications.

show abstract

Section: Litt Probesmentioning

confidence: 99%

Renaissance of laser interstitial thermal ablation

Missios

Bekelis

Barnett

2015

FOC

162

124

View full text Add to dashboard Cite

show abstract

“…These complications, along with cosmetic disfigurement, are a clear indication for treatment and should immediately lead to a suitable therapy [4-8]. Although laser irradiation has been used to induce photo-thermal destruction of hemangiomas, thermal damage to the epidermis remains a concern [6,9,10]. The objective of this study was to determine the efficacy of combining Nd:YAG photocoagulation with the protective use of ice for definitive treatment of hemangiomas in the pediatric population.…”

Section: Introductionmentioning

confidence: 99%

Treatment of hemangiomas in children using a Nd:YAG laser in conjunction with ice cooling of the epidermis: techniques and results

et al. 2003

View full text Add to dashboard Cite

Background: Hemangiomas are the most common type of congenital anomaly in childhood. Although many resolve spontaneously, intervention is required when their growth could damage vital adjacent structures. Various therapeutic approaches to childhood hemangiomas with different types of laser have been described previously. The objective of this study was to determine whether the cooling of the epidermis during irradiation of hemangiomas with a Nd:YAG laser prevents thermal damage and decreases the number of sessions required to treat these lesions.

show abstract

“…Perhaps the most important design enhancement is the active cooling of the applicator tip (cooling or diffusion sheath), which results in peak temperatures that occur away from the laser probe tip. This enables an increase in the diameter of the kill zone and a larger ablation volume, while at the same time protecting the lesion-normal tissue interface [51,52]. Commercial fiber optic tips are presently cooled via gas or liquids, enabling higher initial power use without damage to the fiber optic tip.…”

Section: Technical Developments Of Laser Fiber Applicators For Cerebrmentioning

confidence: 99%

MRI-Guided Laser Interstitial Thermal Therapy in Neuro-Oncology: A Review of Its Current Clinical Applications

et al. 2014

View full text Add to dashboard Cite

Magnetic resonance imaging-guided laser interstitial thermal therapy (LITT) is a minimally invasive treatment modality with recent increasing use to ablate brain tumors. When originally introduced in the late 1980s, the inability to precisely monitor and control the thermal ablation limited the adoption of LITT in neuro-oncology. Popularized as a means of destroying malignant hepatic and renal metastatic lesions percutaneously, its selective thermal tumor destruction and preservation of adjacent normal tissues have since been optimized for use in neuro-oncology. The progress made in real-time thermal imaging with MRI, laser probe design, and computer algorithms predictive of tissue kill has led to the resurgence of interest in LITT as a means to ablate brain tumors. Current LITT systems offer a surgical option for some inoperable brain tumors. We discuss the origins, principles, current indications, and future directions of MRI-guided LITT in neuro-oncology.

show abstract

Nd:YAG laser irradiation in conjunction with cryogen spray cooling induces deep and spatially selective photocoagulation in animal models

Cited by 34 publications

References 27 publications

Renaissance of laser interstitial thermal ablation

Renaissance of laser interstitial thermal ablation

Treatment of hemangiomas in children using a Nd:YAG laser in conjunction with ice cooling of the epidermis: techniques and results

MRI-Guided Laser Interstitial Thermal Therapy in Neuro-Oncology: A Review of Its Current Clinical Applications

Contact Info

Product

Resources

About