Nd:YAG Laser Biostimulation in the Treatment of Bisphosphonate-Associated Osteonecrosis of the Jaw: Clinical Experience in 28 Cases

Abstract

While the results reported in this study are not conclusive, they indicate that laser therapy has potential to improve management of BON.

Effects of low-level laser therapy on the proliferation and apoptosis of gingival fibroblasts treated with zoledronic acid

“…[9][10][11][12] The present study demonstrated that ZA significantly decreased the proliferation of cultured gingival fibroblasts and increased cell apoptosis. Similar data have been reported in previous studies, 8,19,21 in which the authors have stated that the decreased proliferation of epithelial cells and fibroblasts may interfere with the repair of oral mucosal tissue.…”

“…Analysis of these data may explain, at least in part, the excellent clinical results of this therapy. [9][10][11][12] Additionally, LLLT may be effective in biomodulating the oral mucosal cells adjacent to the necrotic area, thus improving the local tissue-healing process. However, further in vitro and in vivo studies are needed to elucidate the effects of bisphosphonates on oral mucosal cells and the association of these drugs with LLLT, which will certainly favour its use in the treatment of osteonecrosis.…”

“…9 Recently, low-level laser therapy (LLLT) has been used clinically as an adjuvant therapy for this pathological condition, mainly due to its positive effect on pain relief and tissue repair. [9][10][11][12] Several researchers have demonstrated the biostimulatory effects of LLLT on different cell types, such as increased cell proliferation, migration, differentiation, and protein synthesis, as well as gene expression of collagen type I and growth factors.…”

“…9 Recently, low-level laser therapy (LLLT) has been used clinically as an adjuvant therapy for this pathological condition, mainly due to its positive effect on pain relief and tissue repair. [9][10][11][12] Several researchers have demonstrated the biostimulatory effects of LLLT on different cell types, such as increased cell proliferation, migration, differentiation, and protein synthesis, as well as gene expression of collagen type I and growth factors. [13][14][15][16][17] Based on the positive effects of LLLT on bisphosphonate-induced osteonecrosis lesions and the toxic effects of these types of drugs on cells, the aim of the present study was to evaluate the proliferation and apoptosis rates of gingival fibroblasts exposed to ZA treatment and subjected to LLLT according to specific parameters.…”

Intérêt de l’oxygénothérapie hyperbare dans la prévention et le traitement des ostéonécroses des maxillaires dues aux bisphosphonates

“…Certains auteurs préconisent une approche chirurgicale dont le but est d'obtenir une fermeture muqueuse pérenne et donc un isolement de l'os par rapport à la cavité buccale, évitant ainsi les surinfections secondaires [5]. Dans ce cas, l'association d'un traitement conservateur au laser à la chirurgie d'exérèse donnerait les meilleurs résultats [30,31]. Les lasers sont utilisés à faible intensité (low level laser therapy -LLLT) [9].…”