Nature’s Anti-inflammatory agent and its use as a Local drug delivery agent for treatment of chronic periodontitis: A clinical, microbiological and biochemical study

Abstract

Periodontal disease can lead to progressive loss of tooth-supporting tissues and alveolar bone. Due to the clinical limitations of scaling and root planing and recolonization of bacteria, the use of systemic and local administration of antimicrobial agents as adjuncts seems beneficial. In recent years, herbal and ayurvedic remedies are being researched to treat common infections and inflammatory conditions. Here an attempt was made to evaluate the effect of curcumin 10mg (Curenext) (CU) used as an adjunct to non-surgical periodontal therapy. A total of 10-15 sites in 14 patients with probing pocket depth 5-7mm were included. In experimental group, sites were treated with SRP+CU and in control group sites were treated with SRP alone. Plaque index, gingival bleeding index, gingival index, probing pocket depth and clinical attachment level were assessed at baseline, 21st day, 30th day, and 90th day. Subgingival plaque samples were collected to assess periodontal pathogens like Porphyromonas gingivalis, Prevotella intermedia and Fusobacterium nucleatum by anaerobic culture. GCF samples were collected to assess lactate dehydrogenase at baseline and 21st day. Results showed significant reduction in clinical parameters (PI, GBI, GI, PPD and CAL) and high statistically significant reduction in periodontal pathogens and lactate dehydrogenase in both the treatment groups, significant difference was seen in SRP+CU group. To conclude, the adjunctive use of curcumin 10mg (curenext* ) as an anti-inflammatory, antimicrobial, and antiplaque agent along with routine mechanical debridement is definitely a promising therapy that would add to the potential benefits of the periodontal treatment.

The Effects of Curcumin Gel Against Tannerella Forsythia (Clinical and Microbiological study)

“…This is due to the elimination of plaque and irritant factors by SRP results in a reduction of a BOP. This finding was in disagreement with studies done by Bhatia et al, Vijayapremakumar et al, and Pandy et al (5,9,10) which showed a significant difference in the BOP between groups.…”

“…Subjects who had used antibiotics or other medications in the previous three months, smokers, and pregnant or lactating women were excluded. The primary outcome in this study was the reduction in p.gingivalis and we determine the sample size by the use of https://gpower.software.informer.com/3.1/ Depending on the SD and mean of SD of p. gingivalis of test group (5) .…”

“…Curcumin (CU) is a diferuloyl methane found in plant extracts (turmeric or rhizome). Three main curcuminoids are found in CU longa (approximately 77 percent CU, 17 percent demethoxycurcumin, and 3 percent bisdemethoxycurcumin) (5) .…”