Naturally-Occurring Xanthones: Recent Developments

Vieira, Luís; Kijjoa, Anake

doi:10.2174/092986705774370682

Cited by 173 publications

(137 citation statements)

References 131 publications

(271 reference statements)

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“…2,3 These natural derivatives can present different substitutions in the xanthone core that include hydroxyl, methoxyl, prenyl and glycosyl groups. 4,5 The inclusion of aryl groups has only been reported for a few synthetic derivatives and the 2,3-diaryl moiety has never been presented before our synthetic work. [6][7][8][9][10] The pharmacological properties of xanthones published in the last decades reveal the growing interest in this type of compounds.…”

Section: Introductionmentioning

confidence: 99%

2,3-Diarylxanthones as strong scavengers of reactive oxygen and nitrogen species: A structure–activity relationship study

Santos

Freitas

Ribeiro

et al. 2010

Bioorganic & Medicinal Chemistry

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a b s t r a c tXanthones are a class of oxygen-containing heterocyclic compounds widely distributed in nature. The natural derivatives can present different substitutions in the xanthone core that include hydroxyl, methoxyl, prenyl and glycosyl groups. The inclusion of aryl groups has only been reported for a few synthetic derivatives, the 2,3-diaryl moiety being recently introduced by our group. Xanthones are endowed with a broad spectrum of biological activities, many of them related to their antioxidant ability, including the scavenging of reactive oxygen species (ROS) and reactive nitrogen species (RNS), as well as metal chelating effects. Considering the interesting and promising antioxidant activities present in compounds derived from the xanthone core, the main goal of this work was to evaluate the scavenging activity of the new 2,3-diarylxanthones for ROS, including superoxide radical (O 2 ÁÀ ), hydrogen peroxide (H 2 O 2 ), singlet oxygen ( 1 O 2 ), peroxyl radical (ROO Å ) and hypochlorous acid (HOCl), and RNS, including nitric oxide ( Å NO) and peroxynitrite anion (ONOO À ). The obtained results revealed that the tested 2,3-diarylxanthones are endowed with outstanding ROS and RNS scavenging properties, considering the nanomolar to micromolar range of the IC 50 values found. The xanthones with two catechol rings were the most potent scavengers of all tested ROS and RNS. In conclusion, the new 2,3-diarylxanthones are promising molecules to be used for their potential antioxidant properties.

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Section: Introductionmentioning

confidence: 99%

2,3-Diarylxanthones as strong scavengers of reactive oxygen and nitrogen species: A structure–activity relationship study

Santos

Freitas

Ribeiro

et al. 2010

Bioorganic & Medicinal Chemistry

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“…Using VIFMAX value of 15 resulted in removing C4F 1 Here a is the statistical significance of the regression based on 5000 randomizations of the dependent variable [9]. Equation (3) has a higher R 2 than that for Equation (2), which implies that using VIFMAX ¼ 35 gives a better model than that obtained by using VIFMAX ¼ 15, at the cost of introducing a small colinearity.…”

Section: Resultsmentioning

confidence: 99%

QSAR of aromatic substances: MAO inhibitory activity of xanthone derivatives

Deeb¹,

Alfalah²,

Clare³

2007

Journal of Enzyme Inhibition and Medicinal Chemistry

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The flip regression procedure that we used earlier for handling the dibenzofuran system has been applied to xanthones. The MAO-A inhibitory activity expressed as IC 50 of the xanthones is known to correlate with E-state, molecular connectivity, shape indices and in this contribution it is shown that the orientation of nodes in their occupied p orbitals explain a further large portion of the variance in their inhibitory activity.

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“…These are further subdivided into various categories such as mono, di, tri, tetra, penta, and hexa oxygenated depending on the level of oxygenation [21][22][23]. For example, 2-hydroxyxanthone (3), 2-hydroxy-1-methoxyxanthone (4).…”

Section: Simple Oxygenated Xanthonementioning

confidence: 99%

Synthesis and Biological Properties of Pharmaceutically Important Xanthones and Benzoxanthone Analogs: A Brief Review.

Bedi

Gupta

Pramanik

2018

Asian J Pharm Clin Res

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Xanthones are one of the biggest classes of compounds in natural product chemistry. A number of xanthones have been isolated from natural sources of higher plants such as fungi, ferns, and lichens. Synthetic analogs of xanthones have shown a large number of pharmacological properties such as antioxidant, anti-inflammatory, antidiabetics, antihistamine, antitumoral, antiulcer, and algicidal. Moreover, they also find usages in photodynamic therapy, laser technology, and dyes. This review lays stress on various solvents, catalyst and synthetic route for synthesis of xanthones, benzoxanthones analogs. The review has also focused on the classifications of xanthone as well as extensively studied biological properties of the xanthones and benzoxanthones analogs.

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Naturally-Occurring Xanthones: Recent Developments

Cited by 173 publications

References 131 publications

2,3-Diarylxanthones as strong scavengers of reactive oxygen and nitrogen species: A structure–activity relationship study

2,3-Diarylxanthones as strong scavengers of reactive oxygen and nitrogen species: A structure–activity relationship study

QSAR of aromatic substances: MAO inhibitory activity of xanthone derivatives

Synthesis and Biological Properties of Pharmaceutically Important Xanthones and Benzoxanthone Analogs: A Brief Review.

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