Naturally Occurring Renal Neurofibroma in a Laboratory Beagle

Zwicker, Gary M.; Cronin, Nancy S.

doi:10.1177/019262339202000113

Cited by 3 publications

(1 citation statement)

References 5 publications

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“…2 Research focused on canine tumours has revealed naturally occurring PNST in different organs such as the nose, neck, periorbital area, flank, colon, zygomatic arch, tongue, kidney and hindlimbs. 1,3,4 Distinct criteria for classification of benign PNST such as schwannoma or neurofibroma have not been agreed upon in the veterinary literature. 5 This is probably because of low incidence of PNST and therefore a lack of studies about these in animals.…”

Section: Intoductionmentioning

confidence: 99%

Immunohistochemical study of a canine neurofibroma

Fattahian

Mortazavi

Moosavian

et al. 2012

J. S. Afr. Vet. Assoc.

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Accurate diagnostic approaches to differentiate peripheral nerve sheet tumours from others have not been firmly established. The aim of this case report was to diagnose neurofibroma using a combination of diagnostic imaging, histopathology and immunohistochemistry, which were applied to a canine neurofibroma arising in the left mandible. The tumour was surgically excised and examined histologically. Round or spindle cells, with elongated, dense and homogenous chromatin and pale cytoplasm typical of Schwann cells in an abundant fibromyxomatous stroma, with ruby collagen fibres were seen. Immunohistochemistry demonstrated that S-100 and vimentin were more than 70% positive. Neurofibroma may therefore be recognisable using markers such as S-100 and vimentin.

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