Congenital mesoblastic nephroma in a young beagle dog.

Yoshizawa, Katsuhiko; Oishi, Yuji; Makino, Natsuyo; Suzuki, Junya; Matsumoto, Masahiro; Fukuhara, Yoshifumi; Fujihira, Shiro; Fujii, Toshiyuki

doi:10.1293/tox.9.101

Cited by 5 publications

(4 citation statements)

References 10 publications

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“…The other 2 renal mesenchymal tumors in beagle dogs were reported to have areas composed of leiomyomatous and primitive mesenchyme-like cells which resembled canine CMN [1,12]. Our case was different from the previous cases with regard to its immunohistochemical characteristics: it was negative for S-100, αSMA and desmin staining [14].…”

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confidence: 72%

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Histopathological, Immunohistochemical and Ultrastructural Studies of a Renal Mesenchymal Tumor in a Young Beagle Dog

Suzuki

Takaba

Yamaguchi

et al. 2012

The Journal of Veterinary Medical Science

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ABSTRACT. A 15-month-old male beagle dog used in a toxicity study had a primary renal mesenchymal tumor. Macroscopically, the tumor was a gray-white mass which was found in the right kidney, and extended from the capsule to a position slightly compressing the medulla. Microscopically, most of the tumor cells showed a myxoid pattern, in which the matrix was positive for alcian blue staining. In the other parts of the tumor, a fascicular and wavy pattern was observed, and the matrix was full of collagen fibrils. Immunohistochemically, tumor cells were positive for vimentin and fibronectin, and negative for cytokeratin, desmin, α-smooth muscle actin, Von Willebrand factor, cyclooxigenase-2 and myelin basic protein. As a result, we diagnosed this case to be a renal mesenchymal tumor. Based on the microscopic findings, interstitial characteristics and immunohistochemical features, the present case was classified as a congenital mesoblastic tumor.KEY WORDS: canine, congenital mesoblastic nephroma, renal mesenchymal tumor.

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confidence: 72%

“…Only 2 previous cases of CMN in beagle dogs have been reported [13,14]. In these reports, the spindle tumor cells had spindle-shaped or oval basophilic nuclei and scant cytoplasm with a few mitotic figures.…”

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confidence: 98%

Histopathological, Immunohistochemical and Ultrastructural Studies of a Renal Mesenchymal Tumor in a Young Beagle Dog

Suzuki

Takaba

Yamaguchi

et al. 2012

The Journal of Veterinary Medical Science

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“…Sequential sections of nodules were stained with periodic acid Schiff (PAS). Immunohistochemistry was performed with antibodies to proliferating cell nuclear antigen (PCNA) to detect the proliferative activity 14 , pancytokeratin (CK) as an epithelial cell marker, vimentin as a mesenchymal cell marker 15 , the common acute lymphoblastic leukemia antigen 10 (CD10) as a uterine interstitial cell marker 16 , α-smooth muscle actin (SMA) and desmin as muscular cell markers 15 , S-100 as a Schwann cell and adipocyte marker 17 , and estrogen receptor α (ER) and progesterone receptor (PgR) to detect steroid hormone receptors 18 . Detailed staining protocols for all antibodies are listed in Table 1…”

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confidence: 99%

Histopathological and Immunohistochemical Characterization of Spontaneously Occurring Uterine Deciduomas in Young Adult Rats

et al. 2013

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Uterine deciduomas were found in two female virgin rats, a 15-week-old Lewis rat and a 7-week-old Sprague-Dawley rat. The firm white nodules were located at the base of unilateral uterine horns and were approximately 6 mm and 4 mm in diameter. Histopathologically, the nodules were composed of three areas, each with a distinct type of proliferating cells: large epithelioid decidual cells with round nuclei, prominent nucleoli and abundant eosinophilic cytoplasm (antimesometrial region); compact spindle-shaped cells with oval nuclei and vacuolar cytoplasm (transitional region); and pleomorphic and spiny cells with round to oval nuclei and compact eosinophilic cytoplasm (mesometrial region). These cells proliferated in sheet-like arrangements and transformed into the other types of cells located in surrounding regions. Immunohistochemically, proliferating cells in all regions were strongly positive for proliferating cell nuclear antigen. The proliferating cells were positive for vimentin, and large decidual cells were positive for common acute lymphoblastic leukemia antigen 10, a marker of uterine interstitial cells. Large decidual cells were positive for α-smooth muscle actin and desmin, suggesting differentiation into muscular cells. Progesterone receptor was expressed in all cell types; however, estrogen receptor α was not expressed in the antimesometrial region. These extremely rare tumor-like nodules represent nonneoplastic lesions referred as decidual reactions of endometrial interstitial cells, and their biological behavior is that of a space-occupying benign tumor in young rats. Our cases might provide information as a historical control in toxicity and pharmacological studies in rats.

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“…Congenital mesoblastic nephroma has been previously described in a 7‐month‐old male beagle dog, in a 10‐month‐old male beagle dog and in a 15‐month‐old male beagle dog. These dogs were kept in a laboratory animal facility, were clinically healthy, and in all cases the renal mass was observed incidentally during necropsy after experimental use (Takeda and others , Yoshizawa and others , Suzuki and others ). A tumour with similar histological features, but which was diagnosed as a mixed mesenchymal tumour, has also been described in an 11‐month‐old female beagle dog used in a toxicity study (Robison and others ).…”

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confidence: 99%

Congenital mesoblastic nephroma in a young basset hound dog

Soldati¹,

Radælli

Mazzuti³

et al. 2012

J of Small Animal Practice

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An 18-month-old male basset hound was presented with vomiting, diarrhoea and depression. Abdominal ultrasonography revealed a mass in the left kidney. An ultrasound-guided core-biopsy indicated aggregates of spindle cells, but did not allow a definitive diagnosis. Nephrectomy was performed after a period of six months, when ultrasound examination revealed a slight increase in mass dimensions. Histologically the mass was composed of neoplastic spindle cells forming interlacing fascicles, bundles and whorls, within a loose myxoid to dense collagenous stroma. Immunohistochemically neoplastic cells were positive for vimentin and smooth muscle actin. Based on these findings the tumour was diagnosed as a congenital mesoblastic nephroma, classical variant. After a two-and-a-half-year follow-up the dog was clinically healthy, indicating a benign behaviour. To the authors' knowledge, this report describes the first case of canine congenital mesoblastic nephroma successfully treated surgically, with a reasonable postsurgical follow-up.

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Congenital mesoblastic nephroma in a young beagle dog.

Cited by 5 publications

References 10 publications

Histopathological, Immunohistochemical and Ultrastructural Studies of a Renal Mesenchymal Tumor in a Young Beagle Dog

Histopathological, Immunohistochemical and Ultrastructural Studies of a Renal Mesenchymal Tumor in a Young Beagle Dog

Histopathological and Immunohistochemical Characterization of Spontaneously Occurring Uterine Deciduomas in Young Adult Rats

Congenital mesoblastic nephroma in a young basset hound dog

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