2012
DOI: 10.1292/jvms.10-0504
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Histopathological, Immunohistochemical and Ultrastructural Studies of a Renal Mesenchymal Tumor in a Young Beagle Dog

Abstract: ABSTRACT. A 15-month-old male beagle dog used in a toxicity study had a primary renal mesenchymal tumor. Macroscopically, the tumor was a gray-white mass which was found in the right kidney, and extended from the capsule to a position slightly compressing the medulla. Microscopically, most of the tumor cells showed a myxoid pattern, in which the matrix was positive for alcian blue staining. In the other parts of the tumor, a fascicular and wavy pattern was observed, and the matrix was full of collagen fibrils.… Show more

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Cited by 5 publications
(7 citation statements)
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“…5,10 Most renomedullary interstitial cells express high levels of cyclooxygenase-2 (COX-2), which is the inducible isoform of prostaglandin-endoperoxide synthase 2. 5,13 In humans, renal interstitial cell tumors are known to be COX-2 positive. 10 Moreover, in humans, these mesenchymal tumors are known as renomedullary interstitial cell tumors, which are benign neoplasms diagnosed only rarely prior to death; they were previously described as medullary fibromas or hamartomas.…”
mentioning
confidence: 99%
“…5,10 Most renomedullary interstitial cells express high levels of cyclooxygenase-2 (COX-2), which is the inducible isoform of prostaglandin-endoperoxide synthase 2. 5,13 In humans, renal interstitial cell tumors are known to be COX-2 positive. 10 Moreover, in humans, these mesenchymal tumors are known as renomedullary interstitial cell tumors, which are benign neoplasms diagnosed only rarely prior to death; they were previously described as medullary fibromas or hamartomas.…”
mentioning
confidence: 99%
“…Congenital mesoblastic nephroma has been previously described in a 7‐month‐old male beagle dog, in a 10‐month‐old male beagle dog and in a 15‐month‐old male beagle dog. These dogs were kept in a laboratory animal facility, were clinically healthy, and in all cases the renal mass was observed incidentally during necropsy after experimental use (Takeda and others , Yoshizawa and others , Suzuki and others ). A tumour with similar histological features, but which was diagnosed as a mixed mesenchymal tumour, has also been described in an 11‐month‐old female beagle dog used in a toxicity study (Robison and others ).…”
Section: Discussionmentioning
confidence: 99%
“…α‐Smooth muscle actin (α‐SMA) represents a marker of fibroblastic cells, that is, Ac‐HSCs, whereas desmin is a marker of quiescent HSC and stains many pericentral fat‐storing cells in normal rat liver . Moreover, immunohistochemical staining for α‐SMA (Dako, Kyoto, Japan) and desmin (Nichirei, Tokyo, Japan) was carried out . Stained sections were analyzed using ImageJ software (version 1.47; https://imagej.nih.gov/ij/; National Institutes of Health, Bethesda, MD, USA).…”
Section: Methodsmentioning
confidence: 99%
“…24 Moreover, immunohistochemical staining for α-SMA (Dako, Kyoto, Japan) and desmin (Nichirei, Tokyo, Japan) was carried out. [25][26][27] Stained sections were analyzed using ImageJ software (version 1.47; https://imagej.nih.gov/ij/; National Institutes of Health, Bethesda, MD, USA). Six microscopic visual fields (magnification ×40) per specimen from 10 rats were used for ImageJ analysis, as previously described.…”
Section: Histological and Immunohistochemical Analysesmentioning
confidence: 99%