Naturally occurring Piper plant amides potential in agricultural and pharmaceutical industries: perspectives of piperine and piperlongumine

Jeon, Hwang‐Ju; Kim, Kyeongnam; YongDeuk, Kim; Lee, Sung‐Eun

doi:10.1186/s13765-019-0471-z

Cited by 24 publications

(14 citation statements)

References 48 publications

(48 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…These compounds increase shelf life of processed meat products, and may also exert some beneficial effects on human health as suggested by their in vitro biological properties [ 27 ]. More particularly, piperine was shown to have cytotoxic effects on cancer cells [ 27 ] and its blood levels have been associated with lower risk of breast cancer in epidemiological studies [ 28 , 29 ]. On the other hand, piperine levels in blood were found to be associated with an increased risk of diabetes [ 30 ].…”

Section: Discussionmentioning

confidence: 99%

“…These metabolites showed very high intensities in the sausage digests compared to non-processed meat digests. These compounds increase shelf life of processed meat products, and may also exert some beneficial effects on human health as suggested by their in vitro biological properties [27]. More particularly, piperine was shown to have cytotoxic effects on cancer cells [27] and its blood levels have been associated with lower risk of breast cancer in epidemiological studies [28,29].…”

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Metabolic Signatures of 10 Processed and Non-processed Meat Products after In Vitro Digestion

et al. 2020

View full text Add to dashboard Cite

The intake of processed meat has been associated with several adverse health outcomes such as type II diabetes and cancer; however, the mechanisms are not fully understood. A better knowledge of the metabolite profiles of different processed and non-processed meat products from this heterogeneous food group could help in elucidating the mechanisms associated with these health effects. Thirty-three different commercial samples of ten processed and non-processed meat products were digested in triplicate with a standardized static in vitro digestion method in order to mimic profiles of small molecules formed in the gut upon digestion. A metabolomics approach based on high-resolution mass spectrometry was used to identify metabolite profiles specific to the various meat products. Processed meat products showed metabolite profiles clearly distinct from those of non-processed meat. Several discriminant features related to either specific ingredients or processing methods were identified. Those were, in particular, syringol compounds deposited in meat during smoking, biogenic amines formed during meat fermentation and piperine and related compounds characteristic of pepper used as an ingredient. These metabolites, characteristic of specific processed meat products, might be used as potential biomarkers of intake for these foods. They may also help in understanding the mechanisms linking processed meat intake and adverse health outcomes such as cancer.

show abstract

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Metabolic Signatures of 10 Processed and Non-processed Meat Products after In Vitro Digestion

et al. 2020

View full text Add to dashboard Cite

show abstract

“…As reported in several studies, ROS generation in excess interferes with various signaling pathways of the cells [54][55][56][57]. Additionally, JNK of the MAPK family plays a pivotal role in regulating autophagy [58][59][60].…”

Section: Celastrol Induces Autophagy and Promotes G2/m Phase Arrest Vmentioning

confidence: 95%

Celastrol-mediated autophagy regulation in cancer

Haroon

Kang

2020

Appl Biol Chem

View full text Add to dashboard Cite

In the last few decades, studies on autophagy regulation and its potential role in cancer therapeutics have expanded to include detailed mechanisms. Since apoptosis exhibits drug resistance in some cancers, efforts have focused on searching for compounds with autophagy modulating properties. Numerous natural compounds have been used in cancer treatment and are considered a significant research area due to their remarkable anti-cancer properties. Celastrol, a quinone methide triterpene, derived from Tripterygium wilfordii, has recently drawn much attention because of its anticancer potential. It enhances tumor suppression and induces autophagy in cancer cells by regulating signaling pathways such as Beclin-1, Akt/mTOR, ROS, NF-κB, MAPK, HSP90, and the proteasome. In the current study, we address the anticancer potential of celastrol, its effect on various cellular pathways, and describe how it functions as an autophagy modulator in cancer therapeutics and helps diminish multidrug resistance in cancer cells.

show abstract

“…antibacterial and antioxidative effects (16)(17)(18)(19). In particular, the observed anticancer effects of herbal mixture extracts have included their ability to boost the efficacy of standard chemotherapies and reduce side effects during chemotherapy (16).…”

Section: Synergistic Effect Of the Herbal Mixture C5e On Gemcitabine mentioning

confidence: 99%

“…Several studies have reported that extracts of herbal mixtures are excellent agents for the treatment of various types of disease, including cardiovascular and Alzheimer's disease and dermatitis ( 13 – 15 ). For example, extracts of herbal mixtures have been shown to exhibit anticancer, anti-inflammatory, antibacterial and antioxidative effects ( 16 – 19 ). In particular, the observed anticancer effects of herbal mixture extracts have included their ability to boost the efficacy of standard chemotherapies and reduce side effects during chemotherapy ( 16 ).…”

Section: Introductionmentioning

confidence: 99%

Synergistic effect of the herbal mixture C5E on gemcitabine treatment in PANC‑1 cells

et al. 2021

View full text Add to dashboard Cite

The present study aimed to determine the anticancer effect of the herbal mixture extract C5E in the pancreatic cancer cell line, PANC-1, in the absence or presence of gemcitabine treatment, a chemotherapeutic drug used for the treatment of pancreatic cancer. The anticancer effects of C5E, gemcitabine and C5E plus gemcitabine in PANC-1 cells following 72 h of treatment were investigated. The effect of each treatment on cell cycle arrest, apoptosis and the proportion of side population (SP) cells was determined using flow cytometric analysis following propidium iodide (PI), Annexin V-FITC/PI double staining and Hoechst 33342 staining, respectively. SP cells share similar characteristics to cancer stem-like cells, and a reduction in the SP is considered to be indicative of an anticancer effect. The percentage of SP cells and the cell viability of general PANC-1 cells were significantly decreased in response to all treatments. The percentage of SP cells was reduced from 8.2% (control) to 3.9, 7.2 and 5.1% following the treatment with C5E, gemcitabine and the co-treatment, respectively. All three treatments were discovered to inhibit cell viability by arresting the cell cycle at the S phase and promoted cell death by inducing early apoptosis, with the levels of apoptosis being increased from 1.9% (control) to 7.3, 2.5 and 12.0% following the treatment with C5E, gemcitabine and the co-treatment, respectively. The mRNA expression levels of sonic hedgehog, which is implicated in the development of certain types of cancer, were downregulated to a greater extent following the co-treatment with C5E and gemcitabine compared with the treatment with either C5E or gemcitabine alone. As the co-treatment with gemcitabine and C5E was more effective than each individual treatment, the present study suggested that the combined treatment may exhibit synergistic effects in PANC-1 cells.

show abstract

Naturally occurring Piper plant amides potential in agricultural and pharmaceutical industries: perspectives of piperine and piperlongumine

Cited by 24 publications

References 48 publications

Metabolic Signatures of 10 Processed and Non-processed Meat Products after In Vitro Digestion

Metabolic Signatures of 10 Processed and Non-processed Meat Products after In Vitro Digestion

Celastrol-mediated autophagy regulation in cancer

Synergistic effect of the herbal mixture C5E on gemcitabine treatment in PANC‑1 cells

Contact Info

Product

Resources

About