Naturally Occurring Isocyano/Isothiocyanato and Related Compounds*

Trichoderma species are free-living fungi that are highly interactive in root, soil and foliar environments and have been used successfully in field trials to control many crop pathogens. Structural and biological studies of the metabolites isolated from Trichoderma species are reviewed. This review, encompassing all the literature in this field up to the present and in which 269 references are cited, also includes a detailed study of the biological activity of the metabolites, especially the role of these metabolites in biological control mechanisms. Some aspects of the biosynthesis of these metabolites and related compounds are likewise discussed.

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“…17) and trichoviridin-type (104) (Fig. 18), with a b-propionic acid or ethyl residue respectively (Chang 2000).…”

Section: Isocyano Metabolitesmentioning

confidence: 99%

Secondary metabolites from species of the biocontrol agent Trichoderma

et al. 2007

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“…In 1988, Breakman reported the isolation of an isonitrile, an isothiocyanate, and an isocyanate from the sponge Acanthella acuta (Banyuls, France) bearing the nitrogen functionality at C-1 instead of C-10 of the aromadendrane skeleton. Due to a misassigned reference substance, a wrong relative configuration was initially published [ 9 , 57 ], which was corrected two years later [ 67 ]. The first two compounds were found in parallel in an Acanthella acuta sponge collected in the Bay of Naples (Italy) by Mayol who elucidated the correct relative stereochemistry of Ar13 and Ar14 [ 62 ].…”

Section: Marine Isonitriles and Related Compoundsmentioning

confidence: 99%

“…The first review about isonitrile natural products was published by Edenborough and Herbert in 1988 [ 7 ] while the first review on marine isonitriles and related compounds by Chang and Scheuer appeared five years later [ 8 ]. Chang also published a review on marine and terrestrial isonitriles along with their congeners in 2000 [ 9 ]. In the same year Garson et al published a review about the structures, biosynthesis and ecology of marine isonitriles [ 10 ].…”

Section: Introductionmentioning

confidence: 99%

Marine Isonitriles and Their Related Compounds

2016

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Marine isonitriles represent the largest group of natural products carrying the remarkable isocyanide moiety. Together with marine isothiocyanates and formamides, which originate from the same biosynthetic pathways, they offer diverse biological activities and in spite of their exotic nature they may constitute potential lead structures for pharmaceutical development. Among other biological activities, several marine isonitriles show antimalarial, antitubercular, antifouling and antiplasmodial effects. In contrast to terrestrial isonitriles, which are mostly derived from α-amino acids, the vast majority of marine representatives are of terpenoid origin. An overview of all known marine isonitriles and their congeners will be given and their biological and chemical aspects will be discussed.

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“…Isocyano natural products, most of them terpenoids of marine origin, have blossomed during the past 20 years into a fruitful area of research. The biological activities of isocyano compounds include antifouling and antimalarial activities [ 24 ]. The trivial name pupukeanane for this new sesquiterpene skeleton continues my practice, begun in 1961, of paying tribute to the rich fl ora and fauna of Hawai'i by coining names that use the sonorous Hawaiian language.…”

Section: Chemical Marine Ecologymentioning

confidence: 99%