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Eleven highly functionalized diterpenes have been isolated from two Pacific marine sponges, Acanthella spp. Each bears two or three isocyano functions, a tertiary alcohol, a tetrahydropyranyl or tetrahydrofuranyl moiety, and occasionally chlorine or isothiocyano substituents. Two representative structures were determined by X-ray diffraction studies, and the others by spectral correlation. All kalihinols inhibit the growth of three test organisms, Bacillus subtilis, Staphylococcus aureus, and Candida albicans.In two preliminary communications3,4 we reported the structures of five isocyano diterpenoid antibiotics, kalihinols A, B, C, E, and F (Chart I), isolated from a Guam sponge, Acanthella sp. This paper provides detailed data for these compounds and for six additional kalihinols, the trace constituents D, G, and H from the Guam Acanthella, and kalihinols X, Y, and Z from a Fiji Acanthella sp. Common to all eleven kalihinols is a trans-decalin bearing a tertiary alcohol at C-4 and in all but three cases isocyano functions at C-5 and C-10. The kalihinols differ in their C8 moiety,

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