Naturally occurring chlorophyll derivatives inhibit aflatoxin B1-DNA adduct formation in hepatoma cells

Hsu, Ching‐Yun; Chen, Yue‐Hwa; Chao, Pi-Yu; Chen, Chiao‐Ming; Hsieh, Ling‐Ling; Hu, Shene-Pin

doi:10.1016/j.mrgentox.2008.08.001

Cited by 35 publications

(32 citation statements)

References 34 publications

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“…Chlorophyllin is consumed by humans for a variety of health benefits including prevention of body odour, enhanced wound healing and as a chemopreventive drug in people who are at high risk of exposure to aflatoxin B1 [30][31][32]. It has also been shown to possess anti-oxidant, anti-apoptotic and immunostimulatory effects in experimental animal models [21,33].…”

Section: ϯϭmentioning

confidence: 99%

Amelioration of radiation-induced hematopoietic syndrome by an antioxidant chlorophyllin through increased stem cell activity and modulation of hematopoiesis

Suryavanshi

Sharma

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et al. 2015

Free Radical Biology and Medicine

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Section: ϯϭmentioning

confidence: 99%

Amelioration of radiation-induced hematopoietic syndrome by an antioxidant chlorophyllin through increased stem cell activity and modulation of hematopoiesis

Suryavanshi

Sharma

Checker

et al. 2015

Free Radical Biology and Medicine

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“…Another plant-based chemoprotective strategy against aflatoxin-induced cancer using chlorophyll (chl) and derivatives, such as the natural metabolites chlorophyllides (chlide) and pheophorbides (pho) [230][231][232], and the semi-synthetic chlorophyllin (chln) is attracting increased commercial and scientific interest [230,233]. The antimutagenic and antigenotoxic activities of chl have long been known, and its anti-carcinogenicity has been extensively demonstrated in experimental animals or in vitro on cancer cell-lines [231,[233][234][235][236][237][238].…”

Section: Natural and Socioeconomic Challengesmentioning

confidence: 99%

Retrospective and Prospective Look at Aflatoxin Research and Development from a Practical Standpoint

Benkerroum

2019

Preprint

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Among the array of structurally and toxicologically diverse mycotoxins, aflatoxins have attracted the most interest of scientific research due to their high toxicity and incidence in foods and feeds. Despite the undeniable progress made in various aspects related to aflatoxins, the ultimate goal consisting of reducing the associated public health risks worldwide is far from being reached due to multiplicity of social, political, economic, geographic, climatic, and development factors. However, a reasonable degree of health protection is attained in industrialized countries owing to their scientific, administrative, and financial capacities allowing them to use high-tech agricultural management systems. Less fortunate situation exists in equatorial and sub-equatorial developing countries mainly practicing traditional agriculture managed by smallholders for subsistence, and where the climate is suitable for mould growth and aflatoxin production. A situation that worsens by the climatic change being increasingly suitable for aflatoxigenic mold growth and toxin production. Accordingly, it is difficult to harmonize the regulatory standards of aflatoxins worldwide, which prevents agri-foods of developing countries from access to the market of industrialized countries. To tackle the multi-facetted aflatoxin problems, actions should be taken collectively by the international community involving scientific research, technological and social development, environment protection, awareness promotion, etc. International cooperation should foster technology transfer and exchange of pertinent technical information. This review presents the main historical discoveries leading to our present knowledge on aflatoxins and the challenges that should be addressed presently and in the future at various levels to ensure higher health protection for everybody. In short, it aims to elucidate where we come from and where we should go in terms of aflatoxin research/development.

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“…Another plant-based chemoprotective strategy against aflatoxin-induced cancer using chlorophyll (chl) and derivatives, such as the natural metabolites chlorophyllides (chlide) and pheophorbides (pho) [192][193][194], and the semi-synthetic chlorophyllin (chln) is attracting increased commercial and scientific interest [192,195]. The antimutagenic and antigenotoxic activities of chl have long been known, and its anti-carcinogenicity has been extensively demonstrated in experimental animals or in vitro on cancer cell-lines [193,[195][196][197][198][199][200].…”

Section: Reducing the Risk By Interfering With The Toxicity Of Aflatomentioning

confidence: 99%

Retrospective and Prospective Look at Aflatoxin Research and Development from a Practical Standpoint

Benkerroum¹

2019

Preprint

View full text Add to dashboard Cite

Among the array of structurally and toxicologically diverse mycotoxins, aflatoxins have attracted the most interest of scientific research due to their high toxicity and incidence in foods and feeds. Despite the undeniable progress made in various aspects related to aflatoxins, the ultimate goal consisting of reducing the associated public health risks worldwide is far from being reached due to multiplicity of social, political, economic, geographic, climatic, and development factors. However, a reasonable degree of health protection is attained in industrialized countries owing to their scientific, administrative, and financial capacities allowing them to use high-tech agricultural management systems. Less fortunate situation exists in equatorial and sub-equatorial developing countries mainly practicing traditional agriculture managed by smallholders for subsistence, and where the climate is suitable for mould growth and aflatoxin production. Accordingly, it is difficult to harmonize the regulatory standards of aflatoxins worldwide, which prevents agri-foods of developing countries from access to the market of industrialized countries. To tackle the multi-facetted aflatoxin problems, actions should be taken collectively by the international community involving scientific research, technological and social development, environment protection, etc. International cooperation should foster technology transfer and exchange of pertinent technical information. This review presents the main historical discoveries leading to our present knowledge on aflatoxins and the challenges that should be addressed presently and in the future at various levels to ensure higher health protection for everybody. In short, it aims to elucidate where we come from and where we should go in terms of aflatoxin research/development.

show abstract

Naturally occurring chlorophyll derivatives inhibit aflatoxin B1-DNA adduct formation in hepatoma cells

Cited by 35 publications

References 34 publications

Amelioration of radiation-induced hematopoietic syndrome by an antioxidant chlorophyllin through increased stem cell activity and modulation of hematopoiesis

Amelioration of radiation-induced hematopoietic syndrome by an antioxidant chlorophyllin through increased stem cell activity and modulation of hematopoiesis

Retrospective and Prospective Look at Aflatoxin Research and Development from a Practical Standpoint

Retrospective and Prospective Look at Aflatoxin Research and Development from a Practical Standpoint

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