Amelioration of radiation-induced hematopoietic syndrome by an antioxidant chlorophyllin through increased stem cell activity and modulation of hematopoiesis

Suryavanshi, Shweta; Sharma, Deepak; Checker, Rahul; Thoh, Maikho; Gota, Vikram; Sandur, Santosh K.; Sainis, Krishna B.

doi:10.1016/j.freeradbiomed.2015.04.007

Cited by 46 publications

(30 citation statements)

References 42 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…It also stimulates the production of haemoglobin and erythrocytes in anaemia [92]. Chlorophyllin [93] (Figure 4) administration has shown to increase the abundance of Hematopoietic stem progenitor cell. Also, it is observed that there was activation of pro-survival transcription factors Nrf-2 and NF-κB, which in turn increased the survival of bone marrow cells.…”

Section: Herbal Remedy For the Treatment Of Pancytopenia Wheatgrassmentioning

confidence: 99%

Herbal approach in the treatment of pancytopenia

Bagwe

Kale

Bhatt

et al. 2017

Journal of Complementary and Integrative Medicine

View full text Add to dashboard Cite

Abstract:Pancytopenia is a health condition in which there is a reduction in the amount of leucocytes, erythrocytes and thrombocytes. If more than one of the blood cells is low then the condition is called as bicytopenia. The pancytopenic condition is observed in treatment of diseased conditions like thalassemia and hepatitis C. Iatrogenically pancytopenia is caused by some antibiotics and anti-HCV drugs. Medical conditions like aplastic anaemia, lymphoma, copper deficiency, and so forth can also cause pancytopenia. Pancytopenia can in turn decrease the immunity of the person and thereby can be fatal. Current therapies for pancytopenia include bone marrow stimulant drugs, blood transfusion and bone marrow transplant. The current therapies are very excruciating and have long-term side-effects. Therefore, treating these condition using herbal drugs is very important. Herbs like wheatgrass, papaya leaves and garlic are effective in treating single lineage cytopenias. The present review is focused on the potential effects of natural herbs for the treatment of pancytopenia.

show abstract

Section: Herbal Remedy For the Treatment Of Pancytopenia Wheatgrassmentioning

confidence: 99%

Herbal approach in the treatment of pancytopenia

Bagwe

Kale

Bhatt

et al. 2017

Journal of Complementary and Integrative Medicine

View full text Add to dashboard Cite

show abstract

“…A recent study examined patients treated with capecitabine and radiation for rectal cancer (similar to our cohort) and found that there are decreases to the mean proton density fat fraction (PDFF), crucial for supporting hematopoiesis, when comparing MRIs before and after CRT (22). For these two reasons, the BM may have less marrow reserve to tolerate ensuing insults (19,23,24). There are no uniform tables to guide clinicians about pelvic bone marrow sparing, as the bone marrow was not allotted dose constraints in the original normal tissue toxicity from radiation tables by Emami (25).…”

Section: Discussionmentioning

confidence: 78%

Bone marrow tolerance during postoperative chemotherapy in colorectal carcinomas

Newman

Moss

Maloney-Patel

et al. 2017

J. Gastrointest. Oncol.

View full text Add to dashboard Cite

Background: This study seeks to quantify and compare bone marrow tolerance during postoperative chemotherapy therapy between rectal cancer vs. colon cancer patients. During rectal cancer treatment, patients receive neoadjuvant chemoradiation (CRT) irradiation which can exacerbate the hematologic toxicity (HT) via incidental irradiation of the pelvic bone marrow (PBM) during myelosuppressive postoperative chemotherapy.In contrast, colon cancer patients receive the same postoperative myelosuppressive chemotherapy but do not routinely receive preoperative chemoradiation therapy. This comparison will help elucidate the lasting myelosuppressive effects of incidental pelvic bone marrow (PBM) irradiation on rectal cancer patients during neoadjuvant preoperative chemoradiation therapy.Methods: Rectal cancer patients treated with preoperative CRT followed by postoperative 5-Fluorouracil and oxaliplatin (OxF) chemotherapy (n=35) were compared to colon cancer patients who received only postoperative OxF chemotherapy (n=42). End points were ≥ grade 3 hematologic toxicity (HT3) or hematologic event (HE) defined as ≥ grade 2 HT and a dose reduction in OxF. Wilcoxon rank sum test tested continuous variables and Chi-squared test measured differences in categorical variables. HT3 and HE probability during postoperative chemotherapy was estimated with Kaplan-Meier curves and Cox regression analysis.Results: During OxF chemotherapy, 40.0% (n=14) of rectal cancer patients experienced HT3 compared to 26.1% (n=11) of colon cancer patients (P=0.4). HE was experienced by 48% (n=17) of rectal cancer patients compared to 36% (n=15) of colon cancer patients (P=0.36). Rectal cancer patients were likelier to experience HT3 on multivariable cox regression analysis, controlling for several clinical covariates, with a hazard ratio (HR) of 2.49, [(95% CI: 1.02-6.02), P=0.045] than colon cancer patients. While rectal cancer patients were more likely to experience HE than colon cancer patients on multivariable Cox regression analysis with a HR of 1.8 (95% CI: 0.95-3.75), this only trended in statistical significance, P=0.07. Conclusions:Rectal cancer patients are more likely than colon cancer patients to experience hematologic toxicities impacting the tolerance of standard of care chemotherapeutics during adjuvant therapy. Focused PBM sparing during radiation therapy for rectal cancer patients may improve tolerance of myelosuppressive chemotherapeutic agents delivered in the postoperative setting.

show abstract

“…Irradiation‐induced body injury is becoming an increasingly serious problem in patients receiving irradiation as it might induce immunosuppression as well. Recently, several natural bioactive substances have shown promising irradiation protective effects, such as resveratrol (Zhang et al., ) and chlorophyllin (Suryavanshi et al., ). The survival rate of whole–body‐irradiation mice was assessed to evaluate the protective effect of COS on mice subjected to irradiation injury.…”

Section: Resultsmentioning

confidence: 99%