Naturally occurring antinociceptive substances from plants

Calixto, João Β.; Beirith, Alessandra; Ferreira, Juliano; Santos, Adair Roberto Soares; Filho, Valdir Cechinel; Yunes, Rosendo A.

doi:10.1002/1099-1573(200009)14:6<401::aid-ptr762>3.0.co;2-h

Cited by 290 publications

(137 citation statements)

References 196 publications

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“…Considering the compounds found in essential oil, the action of α-copaene, α-cadinene, and δ-selinene in bacterial cells are not reported, it is known that the sesquiterpenes are produced by plants to exert antimicrobial activity (Buchanan et al, 2000) by means of interference in the transduction process (Calixto et al, 2000). Mojica et al (2011) assessed the correlation between the antibacterial activity and the components of the essential oil of Calycolpus moritzianus (Myrtaceae) and observed that the components that significantly influenced the antibacterial activity against S. aureus, B. subtilis, and E. faecalis were α-copaene and α-terpineol, both present in P. cattleianum.…”

Section: Resultsmentioning

confidence: 99%

Antimicrobial and antioxidant activity of essential oil and different plant extracts of Psidium cattleianum Sabine

et al. 2016

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The goals of the study were to determine: the antimicrobial and antioxidant activities of essential oil and plant extracts aqueous and ethanolic of Psidium cattleianum Sabine; the chemical composition of the essential oil of P. cattleianum; and the phytochemical screening of aqueous and ethanolic extracts of the same plant. Regarding the antimicrobial activity, the ethanolic extract exhibited moderate antimicrobial activity with respect to bacteria K. pneumoniae and S. epidermidis, whereas, regarding other microorganisms, it showed activity considered weak. The aqueous extract and the essential oil showed activity considered weak, although they inhibited the growth of microorganisms. About the antioxidant potential, the ethanolic and aqueous extracts exhibited a scavenging index exceeding 90%, while the essential oil didn´t show significant antioxidant activity. Regarding the phytochemical composition, the largest class of volatile compounds identified in the essential oil of P. cattleianum included the following terpenic hydrocarbons: α-copaene (22%); eucalyptol (15%), δ-cadinene (9.63%) and α-selinene (6.5%). The phytochemical screening of extracts showed the presence of tannins, flavonoids, and triterpenoids for aqueous and ethanolic extracts. The extracts and essential oils inhibit the growth of microrganisms and plant extracts showed significant antioxidant activity. Also, the phytochemical characterization of the essential oil showed the presence of compounds interest commercial, as well as extracts showed the presence of important classes and compounds with biological activities.Keywords: Psidium cattleianum, antimicrobial action, microdilution, GC-MS, antioxidant activity. Atividade antimicrobiana e antioxidante do óleo essencial e diferentes extratos vegetais de Psidium cattleianum Sabine ResumoOs objetivos do trabalho foram determinar: as atividades antimicrobiana e antioxidante do óleo essencial e dos extratos vegetais aquoso e etanólico de Psidium cattleianum Sabine; a composição química do óleo essencial P. cattleianum e a triagem fitoquímica dos extratos vegetais aquoso e etanólico da mesma planta. Quanto à atividade antimicrobiana, o extrato etanólico apresentou atividade antimicrobiana moderada frente as bactérias K. pneumonieae e S. epidermidis, enquanto frente aos demais micro-organismos apresentou atividade considerada fraca. O extrato aquoso e o óleo essencial apresentaram atividade considerada fraca, embora tenham inibido o crescimento dos micro-organismos. Em relação ao potencial antioxidante, os extratos etanólico e aquoso apresentaram índice de sequestro superior a 90%, enquanto o óleo essencial não apresentou atividade antioxidante significativa. Para a composição fitoquímica, a maior classe de compostos voláteis identificados no óleo essencial de P. cattleianum foram os hidrocarbonetos terpênicos, sendo eles: α-copaeno (22%), eucaliptol (15%), δ-cadineno (9,63%) e α-selineno (6,5%). Na triagem fitoquímica dos extratos verificou-se a presença de taninos, flavonóides e triterpenói...

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Section: Resultsmentioning

confidence: 99%

Antimicrobial and antioxidant activity of essential oil and different plant extracts of Psidium cattleianum Sabine

et al. 2016

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“…A high number of secondary metabolites obtained from medicinal plants, such as monoterpenes, have been extensively studied, with relevant results (Calixto et al, 2000;Almeida et al, 2001;Melo et al, 2010;Quintans-Júnior et al, 2010). In the present study, LEO and LIN demonstrated to play an antinociceptive effect using orofacial nociception tests and to inhibit hippocampal excitability.…”

Section: Discussionmentioning

confidence: 99%

Ocimum basilicum leaf essential oil and (-)-linalool reduce orofacial nociception in rodents: a behavioral and electrophysiological approach

Venâncio¹,

Marchioro²,

Estavam³

et al. 2011

Rev. bras. farmacogn.

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Abstract:The present study investigated the antinociceptive effects of Ocimum basilicum L. (Lamiaceae) leaf essential oil (LEO) and (-)-linalool (LIN) in formalin (2%)-, glutamate (25 μM)-and capsaicin (2.5 µg)-induced orofacial nociception models in mice. The involvement of these substances was further evaluated on the neuronal excitability of the hippocampal dentate gyrus. Male mice (n=8/group) were pretreated separately with LEO and by LIN (50, 100, and 200 mg/kg, i.p.), morphine (5 mg/kg, i.p.) and vehicle (saline + Tween 80 0.2%), before injection of nociceptive agent into the right upper lip (perinasal area). The LEO and LIN reduced the nociceptive face-rubbing behaviour in both phases on formalin test. LEO and LIN, at high doses, produced significantly antinociceptive effect in the capsaicin and glutamate tests. In hippocampal slices, LEO inhibited the population spike generated by stimulation of the hylus (antidromic stimulation), with an IC50 of 0.1±0.05 mg/mL. This response was reversibly blocked by lidocaine (0.5 mg/mL), a known voltage-dependent sodium channel antagonist and by LIN (0.5 mg/mL). Our results suggest that LEO and LIN modulate neurogenic and inflammatory pain in the tests of orofacial nociception induced by formalin, capsaicin and glutamate. Part of these effects may be associated with decreased peripheral and central neuronal excitability.

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“…The writhing test is considered a non-specific model (e.g. anticholinergic and antihistaminic and other agents show activity in this assay), but it is frequently used for analgesic screening and involves local peritoneal receptors (cholinergic and histamine receptor) and acetylcholine and histamine mediators (Calixto et al, 2000;Choi et al, 2003). The acetic acid model is generally used to evaluate the action of peripheral drugs, acting indirectly by inducing the release of endogenous mediators, which stimulate nociceptive neurons that are sensitive to non-steroidal anti-inflammatory drugs and/ or opioids (Collier et al, 1968).…”

Section: Discussionmentioning

confidence: 99%

Antinociceptive effects of Abarema cochliacarpos (B.A. Gomes) Barneby & J.W.Grimes (Mimosaceae)

Silva¹,

Esquibel²,

Alves³

et al. 2009

Rev. bras. farmacogn.

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RESUMO: "Efeito antinociceptivo de Abarema cochliacarpos (B.A. Gomes) Barneby & J.w.Grimes (Mimosaceae)". No presente trabalho foram avaliados a atividade antinociceptiva e o perfil fitoquímico dos extratos aquosos e metanólico produzidos com a casca do caule de Abarema cochliacarpos, uma espécie de Mata Atlântica com diversas indicações populares. Todos os extratos apresentaram atividade analgésica quando avaliados pelo teste das contorções abdominais induzidas pelo ácido acético via intraperitonial, apresentando respostas superiores às drogas usadas como referência, bem como no modelo da dor induzida por capsaicina. A avaliação fitoquímica demonstrou a presença de saponinas, catequinas, taninos, fenóis e antraquinonas.Unitermos: Abarema cochliacarpos, Mimosaceae, atividade analgésica, plantas medicinais, perfil fitoquímico. ABSTRACT:In this study, we investigated the analgesic activity of crude aqueous and methanol extracts obtained from Abarema cochliacarpos bark in mice, and analyzed its phytochemical profile. All the extracts exhibited analgesic properties against the writhing test in mice, but the aqueous and methanol extracts were more active, and more potent than two known analgesic and anti-inflammatory drugs used as reference. They were also active against the capsaicin-model, but inactive when evaluated in the hot-plate test. Phytochemical studies revealed the presence of saponins, catechins, tannins, phenols and anthraquinones.

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Naturally occurring antinociceptive substances from plants

Cited by 290 publications

References 196 publications

Antimicrobial and antioxidant activity of essential oil and different plant extracts of Psidium cattleianum Sabine

Antimicrobial and antioxidant activity of essential oil and different plant extracts of Psidium cattleianum Sabine

Ocimum basilicum leaf essential oil and (-)-linalool reduce orofacial nociception in rodents: a behavioral and electrophysiological approach

Antinociceptive effects of Abarema cochliacarpos (B.A. Gomes) Barneby & J.W.Grimes (Mimosaceae)

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