Naturally occurring and artificially induced tumor-like formations in marine invertebrates: A search for permanent cell lines

Odintsova, N. A.; Usheva, L. N.; Yakovlev, Konstantin V.; Kiselev, Konstantin V.

doi:10.1016/j.jembe.2011.06.020

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Cited by 13 publications

(2 citation statements)

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“…There have been attempts to produce a permanent cell line of bivalve neoplastic cells (Walker et al, 2009;Odintsova et al, 2011). Encouraging results involving in vitro proliferation of M. arenaria neoplastic cells through various passages (subculture), which kept tumorigenic ability, were reported by Walker et al (2009).…”

Section: Geneticmentioning

confidence: 99%

Neoplastic diseases of marine bivalves

Carballal

Barber

Iglesias

et al. 2015

Journal of Invertebrate Pathology

116

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Section: Geneticmentioning

confidence: 99%

Neoplastic diseases of marine bivalves

Carballal

Barber

Iglesias

et al. 2015

Journal of Invertebrate Pathology

116

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“…Most genes responsible for the biosynthesis of drugs have been indentified and sequenced (Molinski et al 2009). At present, scientists are working on the development of permanent cell lines of marine invertebrates (Odintsova et al 2011).…”

Section: Introductionmentioning

confidence: 99%

Biologically active substances from water invertebrates: a review

Šinko¹,

Rajchard²,

Balounová³

et al. 2012

Vet. Med. - Czech

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Some species of invertebrates especially bryozoans (Bryozoa syn. Ectoprocta) and marine sponges (Porifera) are very important sources of pharmacologically exploitable compounds. These substances are probably produced to protect themselves from fish predators and may be an advantage in competition. The real sources of compounds with these antipredatory effects are probably not marine invertebrates themselves, but microscopic symbionts or food which they feed on. Bryostatins from bryozoan species Bugula neritina are produced by a bacterial symbiont called Candidatus Endobugula sertula. They have significant anti-cancer effects, but also other therapeutic benefits. Compounds with the structure of bryostatins were also discovered in some other invertebrates. Sponges are a source of many compounds, e.g., ara-A (vidarabine), manzamine, lasonolides, spongistatins, peloruside and others with antimicrobial, anti-cancer, immunosuppressive and similar activities. Other important sources of compounds with medical effects are tunicates (Tunicata syn. Urochordata) and some snails (Mollusca). One drug was developed from tunicates – Yondelis against refractory soft-tissue sarcomas. Certain other drugs originate from snails: e.g., prialt, which acts against chronic pain in spinal cord injury.  

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