The Mystery of Cancer Resistance: A Revelation Within Nature

Trivedi, Devangkumar D.; Dalai, Sarat K.; Bakshi,

doi:10.1007/s00239-023-10092-6

Cited by 7 publications

(5 citation statements)

References 203 publications

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“…In this study we used a previously established rodent model of GBM to comparatively characterize disease progression in animals with different hypoxia resistance regarded as a trait. It is known that there are organisms resistant to hypoxia and the development of cancer, for example, naked mole rat and blind mole rat, which is substantiated due to a high level of protection against oxidative stress 76 – 79 . We have demonstrated for the first time that within the same species there are also differences in resistance to tumor progression.…”

Section: Discussionmentioning

confidence: 99%

Morphological and molecular-biological features of glioblastoma progression in tolerant and susceptible to hypoxia Wistar rats

Джалилова

Золотова

Мхитаров

et al. 2023

Sci Rep

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Hypoxia is a major pathogenetic factor in many cancers. Individual resistance to suboptimal oxygen availability is subject to broad variation and its possible role in tumorigenesis remains underexplored. This study aimed at specific characterization of glioblastoma progression in male tolerant and susceptible to hypoxia Wistar rats. Hypoxia resistance was assessed by gasping time measurement in an 11,500 m altitude-equivalent hypobaric decompression chamber. Based on the outcome, the animals were assigned to three groups termed ‘tolerant to hypoxia’ (n = 13), ‘normal’, and ‘susceptible to hypoxia’ (n = 24). The ‘normal’ group was excluded from subsequent experiments. One month later, the animals underwent inoculation with rat glioblastoma 101.8 followed by monitoring of survival, body weight dynamics and neurological symptoms. The animals were sacrificed on post-inoculation days 11 (subgroup 1) and 15 (subgroup 2). Relative vessels number, necrosis areas and Ki-67 index were assessed microscopically; tumor volumes were determined by 3D reconstruction from histological images; serum levels of HIF-1α, IL-1β, and TNFα were determined by ELISA. None of the tolerant to hypoxia animals died of the disease during observation period, cf. 85% survival on day 11 and 55% survival on day 15 in the susceptible group. On day 11, proliferative activity of the tumors in the tolerant animals was higher compared with the susceptible group. On day 15, proliferative activity, necrosis area and volume of the tumors in the tolerant to hypoxia animals were higher compared with the susceptible group. ELISA revealed no dynamics in TNFα levels, elevated levels of IL-1β in the susceptible animals on day 15 in comparison with day 11 and tolerant ones. Moreover, there were elevated levels of HIF-1α in the tolerant animals on day 15 in comparison with day 11. Thus, the proliferative activity of glioblastoma cells and the content of HIF-1α were higher in tolerant to hypoxia rats, but the mortality associated with the tumor process and IL-1β level in them were lower than in susceptible animals. Specific features of glioblastoma 101.8 progression in tolerant and susceptible to hypoxia rats, including survival, tumor growth rates and IL-1β level, can become the basis of new personalized approaches for cancer diseases treatment in accordance to individual hypoxia resistance.

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Section: Discussionmentioning

confidence: 99%

Morphological and molecular-biological features of glioblastoma progression in tolerant and susceptible to hypoxia Wistar rats

Джалилова

Золотова

Мхитаров

et al. 2023

Sci Rep

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“…Il est donc essentiel de noter qu'il existe une vulnérabilité différentielle des espèces animales au cancer. Les espèces de grande taille ou à longue durée de vie ne sont pas plus sujettes au cancer, et diverses solutions au paradoxe de Peto ont été identifiées (voir aussi pour synthèses [42,43]). Cela n'est pas surprenant étant donné que des espèces de grande taille sont apparues à plusieurs reprises dans l'histoire des organismes multicellulaires.…”

Section: Le Cas Des Chauves-sourisunclassified

Évolution de la résistance au cancer dans le monde animal

Thomas,

Ujvari,

Dujon

2024

Med Sci (Paris)

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Le cancer est un dommage collatéral inévitable inhérent à l’évolution des organismes multicellulaires, apparus à la fin du Précambrien. L’exploration de la manière dont les animaux, en particulier ceux de grande taille et de longue durée de vie, font face au cancer, comporte des enjeux à la fois fondamentaux et appliqués. Dans cet article, nous commençons par présenter le cadre conceptuel nécessaire pour comprendre les théories qui traitent de l’évolution des défenses anti-cancéreuses. Nous présentons ensuite un certain nombre d’exemples, notamment les rats-taupes nus, les éléphants, les baleines, les xénarthres (paresseux, tatous et fourmiliers), les chauves-souris et les placozoaires1. Les contributions de la génomique comparative à la compréhension des convergences évolutives sont également abordées. Enfin, nous indiquons que la sélection naturelle a également favorisé des adaptations visant à éviter les zones mutagènes, par exemple, ou à maximiser l’effort de reproduction immédiat en cas de cancer. L’exploration de ces solutions, intéressante conceptuellement, pourrait aussi permettre d’envisager de nouvelles approches thérapeutiques pour la santé humaine.

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“…In the long term, it is possible that natural selection will favor the development of more powerful anticancer defenses, such as duplications of tumor suppressor genes (e.g. (Sulak et al 2016) (Trivedi et al 2023)). Thus, the consequences of anthropogenically induced oncogenic activities on wildlife are diverse and complex, warranting further in-depth research, especially in aquatic ecosystems that are particularly prone to pollution (Häder et al 2020).…”

Section: Introductionmentioning

confidence: 99%

Consequences of Cancer on ZebrafishDanio rerio: Insights into Sex Determination, Sex Ratio, and Offspring Survival

Boutry,

Douhard,

Asselin

et al. 2024

Preprint

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Offspring sex ratio has been proposed as an indicator of the risk of developing certain cancers in humans, but offspring sex ratio may also be a consequence of the disease. In this study, we delve into this subject using the fish Danio rerio as a model system. First, we explore whether inducing skin cancer at an early stage of the host's life (embryonic stage) has the potential to influence sex determination and/or sex-specific mortality. Second, we investigate whether the sex ratio in offspring produced by tumor-bearing adult females differs from that of healthy females. Third, we compare the survival (until sexual maturity) of offspring produced by cancerous and non-cancerous females. We found that skin cancer did not influence sex ratio in both experiments. However, consistent with previous studies on other model systems, the survival of offspring from cancerous females was higher, suggesting that diseased females allocate more resources to current reproductive efforts compared to their healthy counterparts. This study makes a significant contribution to our understanding of the ecological and evolutionary consequences of host-tumor interactions in animals.

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The Mystery of Cancer Resistance: A Revelation Within Nature

Cited by 7 publications

References 203 publications

Morphological and molecular-biological features of glioblastoma progression in tolerant and susceptible to hypoxia Wistar rats

Morphological and molecular-biological features of glioblastoma progression in tolerant and susceptible to hypoxia Wistar rats

Évolution de la résistance au cancer dans le monde animal

Consequences of Cancer on ZebrafishDanio rerio: Insights into Sex Determination, Sex Ratio, and Offspring Survival

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