Naturally Leishmania infantum-infected dogs display an overall impairment of chemokine and chemokine receptor expression during visceral leishmaniasis

Nascimento, Manuela Sales Lima; Albuquerque, T.D.R.; Do-Valle-Matta, Maria Adelaide; Caldas, Ivo Santana; Diniz, Lívia de Figueiredo; Talvani, André; Bahia, Maria T.; Andrade, Cléber de Mesquita; Galvão, Lúcia Maria da Cunha; Câmara, Antônia Claudia Jácome da; Guedes, Paulo Marcos da Matta

doi:10.1016/j.vetimm.2013.02.015

Cited by 17 publications

(23 citation statements)

References 22 publications

(28 reference statements)

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“…Nascimento et al also reported changing chemokine and chemokine receptor profiles in the spleens of dogs with varying clinical forms of CanL (Nascimento et al 2013). The authors looked at chemokines from the CC-family chemokine ligand family (CCL), chemokine motif ligand (CXCL), CXC chemokine receptors (CXC) and beta chemokine receptors (CCR).…”

Section: Organ Specific Immune Responsesmentioning

confidence: 98%

“…Hosein et al also reported a significant down regulation of IL-22 transcription in both liver and spleen samples when non-infected controls were compared with L. infantum infected dogs (Hosein et al 2015). Nascimento et al investigated chemokine and cytokine receptor expression in dogs naturally infected with L. infantum (Nascimento et al 2013). In the liver of symptomatic dogs, a significant down regulation was noted for expression of beta chemokine receptors (CCR), CCR3, CCR4, CCR5, CCR6 and CCR8 when compared with expression levels in asymptomatic dogs.…”

Section: Organ Specific Immune Responsesmentioning

confidence: 99%

“…In the liver of symptomatic dogs, a significant down regulation was noted for expression of beta chemokine receptors (CCR), CCR3, CCR4, CCR5, CCR6 and CCR8 when compared with expression levels in asymptomatic dogs. These chemokines were also downregulated when symptomatic dogs were compared with healthy non-infected controls (Nascimento et al 2013). The authors concluded that the suppression of these receptors seen in symptomatic dogs was possibly due to a reduced migration of immune cells, which would normally assist with parasite clearance and granuloma formation (Nascimento et al 2013).…”

Section: Organ Specific Immune Responsesmentioning

confidence: 99%

“…These chemokines were also downregulated when symptomatic dogs were compared with healthy non-infected controls (Nascimento et al 2013). The authors concluded that the suppression of these receptors seen in symptomatic dogs was possibly due to a reduced migration of immune cells, which would normally assist with parasite clearance and granuloma formation (Nascimento et al 2013). Recently, the same authors documented that the progression of this disease was characterized not only by the down regulation of T helper (Th) 1-related cytokines, such as IFN- γ and TNF- α , but also by the down regulation of genes encoding interleukin (IL)-17A, inducible NO synthase (iNOS) and IL-10 in the spleen and liver in symptomatic dogs compared with asymptomatic dogs (Nascimento et al 2015).…”

Section: Organ Specific Immune Responsesmentioning

confidence: 99%

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Insights on adaptive and innate immunity in canine leishmaniosis

2016

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SUMMARYCanine leishmaniosis (CanL) is caused by the parasite Leishmania infantum and is a systemic disease, which can present with variable clinical signs, and clinicopathological abnormalities. Clinical manifestations can range from subclinical infection to very severe systemic disease. Leishmaniosis is categorized as a neglected tropical disease and the complex immune responses associated with Leishmania species makes therapeutic treatments and vaccine development challenging for both dogs and humans. In this review, we summarize innate and adaptive immune responses associated with L. infantum infection in dogs, and we discuss the problems associated with the disease as well as potential solutions and the future direction of required research to help control the parasite.

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Section: Organ Specific Immune Responsesmentioning

confidence: 98%

Section: Organ Specific Immune Responsesmentioning

confidence: 99%

Section: Organ Specific Immune Responsesmentioning

confidence: 99%

Section: Organ Specific Immune Responsesmentioning

confidence: 99%

See 2 more Smart Citations

Insights on adaptive and innate immunity in canine leishmaniosis

2016

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“…CCR6 and its ligand are no exception, and this study was limited to measuring the level of the gene, and this result was not verified by also measuring the protein level, which is the next stage in our study. Therefore, the influence mechanism between CCR6 and psoriasis and NB-UVB on CCR6 level of psoriasis patients needs to be studied further (Nascimento et al, 2013).…”

Section: Discussionmentioning

confidence: 99%

Effect of NB-UVB on levels of MCP-1 and CCR6 mRNA in patients with psoriasis vulgaris

Ml¹,

Ag²

2015

Genet. Mol. Res.

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ABSTRACT. The aim of this study is to explore the effect of narrow band ultraviolet B (NB-UVB) on the chemokine receptor CCR6 mRNA levels in patients with psoriasis. Psoriasis area and severity index (PASI) values were recorded before and after the treatment with NB-UVB phototherapy of 30 psoriasis vulgaris patients. The reverse transcription-polymerase chain reaction method was used to detect the expression level of CCR6 mRNA in peripheral blood mononuclear cells, and compared with 30 healthy subjects. The PASI value of the 30 psoriasis vulgaris patients decreased significantly after 15 iterations of phototherapy treatment (P < 0.01). The expression level of CCR6 mRNA in psoriasis patients was significantly higher than in the healthy controls (P < 0.01), while the expression level of CCR6 mRNA decreased significantly after phototherapy (P < 0.01). Reduction of CCR6 level may be one of the mechanisms through which NB-UVB can treat psoriasis.

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