Naturally Derived a-Tricalcium Phosphate Based Porous Composite Bead Production

Abstract

In this study, a simple, innovative approach is applied to produce porous a-TCP-CeO2-Al2O3 composite beads via using bovine bone-derived hydroxyapatite, cerium oxide, and alumina ceramics. Bovine-bone derived hydroxyapatite was obtained via calcination of bones at 950°C for 3 hours. Hydroxyapatite is a thermally unstable biomaterial at high temperatures, and depending on its stoichiometry decomposes at 800-1200°C. Sodium alginate was successfully used as an in situ gelling templates for the production of the ceramic beads and starch, an environmentally friendly and economic pore-forming agent, is used to achieve interconnected, highly open porosity containing composite beads. Sintering of the ceramic−starch−alginate green composite beads at 1200°C for 1 hour resulted in the decomposition of the hydroxyapatite phase and formation of a-TCP. XRD analysis revealed that a-TCP-CeO2-Al2O3 composite beads were achieved. XRD analysis confirmed the formation of a-TCP phase in all composite compositions. SEM investigations of the produced composite beads revealed that bimodal pore size distribution, fine and coarse, was achieved.

Biomedical applications of three‐dimensional bioprinted craniofacial tissue engineering

“…In one of the approaches, AYDIN et al fabricated the porous a‐TCP‐CeO 2 ‐Al 2 O 3 composite via using bovine bone‐derived HA and alumina ceramics. 129 Several other reports also confirmed the role of calcium phosphate in bone reconstruction. The use of nanomaterials also offers an excellent method for bone tissue scaffold generation.…”

“…Hence attempts were made to combine alumina and HA to form the bioinert but at the same time, bone and tissue interacting composite. In one of the approaches, AYDIN et al fabricated the porous a‐TCP‐CeO 2 ‐Al 2 O 3 composite via using bovine bone‐derived HA and alumina ceramics 129 . Several other reports also confirmed the role of calcium phosphate in bone reconstruction.…”