Natural Variation of Canine Parvovirus

Parrish, Colin R.; O'Connell, Priscilla H.; Evermann, James F.; Carmichael, L E

doi:10.1126/science.4059921

Cited by 256 publications

(206 citation statements)

References 9 publications

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“…After its emergence in the late 1970s [2] CPV-2 underwent a rapid evolution and, within few years, new antigenic types termed CPV-2a and CPV-2b, completely replaced the original CPV-2 [3]. Few years back an antigenic variant had been reported in Italy [4].…”

Section: Introductionmentioning

confidence: 99%

Isolation and Typing of Canine Parvovirus in CRFK Cell Line in Puducherry, South India

Parthiban

Mukhopadhyay²,

Panneer³

et al. 2011

Indian J Microbiol

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A total of 128 faecal samples/rectal swabs were collected from dogs showing signs of diarrhea/enteritis in and around Puducherry, South India. Eighteen clinical samples, showing high HA titre of 1:512 and above and positivity by polymerase chain reaction (PCR) with CPV2ab primers, were subjected to virus isolation in CRFK cell line. Of the 18 samples processed, 3 samples (16.6%) were positive for CPV and were confirmed by haemagglutination, dot-ELISA, and IFAT. The three cell culture isolates were characterized as CPV-2b types by multiplex PCR as well as by monoclonal antibody typing.

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Section: Introductionmentioning

confidence: 99%

Isolation and Typing of Canine Parvovirus in CRFK Cell Line in Puducherry, South India

Parthiban

Mukhopadhyay²,

Panneer³

et al. 2011

Indian J Microbiol

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“…Mouse monoclonal antibody (Mab) A3B10, which neutralizes CPV2 [15], was prepared as previously described [29][30][31]. This antibody, Mab A3B10 is the same as Mab 8 described in [15,30].…”

Section: Virus and Monoclonal Antibody Productionmentioning

confidence: 99%

The structure of a neutralized virus: canine parvovirus complexed with neutralizing antibody fragment

et al. 1994

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Background-Members of the Parvovirus genus cause a variety of diseases in mammals, including humans. One of the major defences against viral infection is the presence of neutralizing antibodies that prevent virus particles from infecting target cells. The mechanism of neutralization is not well understood. We therefore studied the structure of canine parvovirus (CPV) complexed with the Fab fragment of a neutralizing antibody, A3B10, using image reconstruction of electron micrographs of vitrified samples, together with the already known structure of CPV from X-ray crystallographic data.

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“…The appearance of new subtype of this virus generally present less severe disease in dogs that have a better survival rate [24,26]. However, puppies born in breeding populations have greater risk of infections that are often fatal [5].…”

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confidence: 99%

Clinical Effects of the Recombinant Feline Interferon-.OMEGA. on Experimental Parvovirus Infection in Beagle Dogs.

Ishiwata

Minagawa

Kajimoto

1998

The Journal of Veterinary Medical Science

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ABSTRACT. The clinical effects of recombinant feline interferon-ω (rFeIFN-ω), produced in silkworm by recombinant baculovirus, were examined in 3-4 month-old beagle dogs given an experimental canine parvovirus type-2 (CPV-2) infection. Clinical symptoms, such as pyrexia, vomiting, anorexia and diarrhea, were observed on day 4 after oral inoculation of 10 7 TCID 50 of CPV-2 (cc 238 strain) in almost all the inoculated dogs. From day 4, rFeIFN-ω (1 mega units/kg/day) or physiological saline was administered intravenously to infected dogs for 3 consecutive days. Seven out of 17 dogs treated with physiological saline showed hemorrhagic diarrhea and continuously expressed severe clinical enteritis; one dog died with a large amount of hemorrhagic rice-water stool on day 6 after viral exposure. In contrast, 4 out of 12 dogs treated with rFeIFN-ω showed severe clinical enteritis associated with intermittent diarrhea. Scoring of fecal condition revealed that treatment with rFeIFN-ω significantly shifted the enteritis from a severe to mild form. Furthermore, rFeIFN-ω administered in the morning decreased the number of dogs expressing clinical enteritis in the evening suggesting a rapid effect. Vomiting and anorexia were also improved by treatment with rFeIFN-ω. These results suggest that rFeIFN-ω can reduce severe enteritis caused by CPV-2 infection in dogs. -KEY WORDS: beagle dog, canine parvovirus, enteritis, experimental infection, recombinant feline interferon-ω.J.

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Natural Variation of Canine Parvovirus

Cited by 256 publications

References 9 publications

Isolation and Typing of Canine Parvovirus in CRFK Cell Line in Puducherry, South India

Isolation and Typing of Canine Parvovirus in CRFK Cell Line in Puducherry, South India

The structure of a neutralized virus: canine parvovirus complexed with neutralizing antibody fragment

Clinical Effects of the Recombinant Feline Interferon-.OMEGA. on Experimental Parvovirus Infection in Beagle Dogs.

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