Natural toxic background in the food of man and his animals

Crosby, Donald G.

doi:10.1021/jf60163a009

Cited by 7 publications

(1 citation statement)

References 25 publications

(33 reference statements)

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“…This may reflect an intuitive belief that foods and drugs somehow represent totally different classes of chemicals. Nevertheless, it should be noted that non nutrient compounds in the diet are a major source of exposure of man to foreign chemicals 8 , 13 and that some of the macroconstituents of the human diet (i.e., carbohydrate and protein) have been shown to alter drug disposition in man. 2 , 21 In the present study, the influence of a short period of ingestion of charcoal-broiled beef on the metabolism of theophylline and antipyrine in normal male volunteers was investigated.…”

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Effect of charcoal‐broiled beef on antipyrine and theophylline metabolism

Kappas

Alvares

Anderson

et al. 1978

Clin Pharma and Therapeutics

130

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Eight healthy volunteers were sequentially fed a control diet, a charcoal-broiled beef--containing diet, and the control diet a second time. The mean plasma half-lives (t1/2) of antipyrine and theophylline were each decreased by 22% after the subjects were fed the charcoal-broiled beed--containing diet. The main plasma t1/2s for these drugs returned to control values when the subjects were fed the control diet for a second time. Considerable individuality occurred in the responsiveness of the subjects to the charcoal-broiled beef--containing diet. The decreases in antipyrine plasma t1/2s among the 8 subjects ranged from 5% to 39%, and the decreases in theophylling t1/2s ranged from 0% to 42%.

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confidence: 99%