Pancreatic Disease: A Casualty of Hepatic "Detoxification"?

Braganza, J. M.

doi:10.1016/s0140-6736(83)90983-2

Cited by 109 publications

(46 citation statements)

References 44 publications

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“…Indirect evidence supporting this hypothesis comes from a study reporting increased biliary levels of malonyldialdehyde, an index of lipid peroxidation, in rats treated with ethanol and/or intron dextran (40). Excretion of lipid peroxides, toxic epoxides, carcinogens, and free radicals into bile has been hypothesized to be the cause of pancreatic disease (41).…”

Section: Discussionmentioning

confidence: 99%

Potential role of conjugated bilirubin and copper in the metabolism of lipid peroxides in bile.

Stocker

Ames

1987

Proc. Natl. Acad. Sci. U.S.A.

125

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Conjugated bilirubin and copper ions at their physiological concentrations in bile may play an important role in hydroperoxide and other detoxification. Conjugated bilirubin may also be an important chain-breaking antioxidant preventing lipid peroxidation. Bilirubin ditaurine (BR-DT), a water-soluble model compound of conjugated bilirubin, completely prevents the peroxyl radical-induced oxidation of phosphatidylcholine in either multilamellar liposomes or micelles. This antioxidant activity is associated with the bilirubin moiety of BR-DT, since taurine alone is inefficient in scavenging peroxyl radicals. The number of peroxyl radicals trapped per molecule of BR-DT is 1.9, compared to 4.7 trapped per molecule of biliverdin, the water-soluble physiological precursor of bilirubin. Peroxyl radical-induced oxidation of BR-DT results in a spectral shift in maximal absorbance toward shorter wavelengths; biliverdin is not formed as a major oxidation product. BR-DT, but neither taurine nor biliverdin, greatly accelerates the cupric ion-catalyzed decomposition of linoleic acid hydroperoxide. In the presence of ferric ion, BR-DT shows no lipid hydroperoxide-degrading activity. Addition of cupric ion to BR-DT results in formation of a complex with spectral features similar to that of a biliverdin-cupric ion complex, indicating that BR-DT and cupric ion undergo redox reactions.

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Section: Discussionmentioning

confidence: 99%

Potential role of conjugated bilirubin and copper in the metabolism of lipid peroxides in bile.

Stocker

Ames

1987

Proc. Natl. Acad. Sci. U.S.A.

125

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“…The fourth hypothesis, the 'oxidative stress hypothesis', 79 postulates that oxidative stress in pancreatic acinar cells induced by excess free radicals causes a blockade of the intracellular pathway, fusion of lysosomal and zymogenic compartments, and membrane lipid oxidation. These events then lead to an inflammatory response.…”

Section: Pathogenesismentioning

confidence: 99%

Chronic pancreatitis, pseudotumors and other tumor-like lesions

2007

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“…The potential role of metabolic enzyme genetic polymorphisms in increasing or decreasing the risk of pancreatic cancer remains unclear. Few studies on this subject exist, and their methods allow no conclusions to be drawn (22,25,26).…”

Section: Genetic Aspectsmentioning

confidence: 99%

“…El papel que puedan tener los polimorfos genéticos de enzimas metabolizadoras, aumentando o disminuyendo el riesgo de cáncer de páncreas, no está aún claro. Existen pocos estudios al respecto y la metodología empleada en ellos no permite establecer conclusiones (22,25,26).…”

Section: Ink4aunclassified