Natural terpenes: Self-assembly and membrane partitioning

Turina, Anahi del Valle; Nolan, M Verónica; Zygadlo, Julio Alberto; Perillo, Marı́a A.

doi:10.1016/j.bpc.2006.02.007

Cited by 247 publications

(163 citation statements)

References 37 publications

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“…However, Turina et al (2006) reported that owing the high hydrophobicity of monoterpenes, their toxic effects on the bacterial cell membrane result in its expansion, fluidity, and permeability, in addition to causing inhibition of respiration and change in the process of ions transport.…”

Section: Resultsmentioning

confidence: 99%

Antimicrobial and antioxidant activity of essential oil and different plant extracts of Psidium cattleianum Sabine

et al. 2016

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The goals of the study were to determine: the antimicrobial and antioxidant activities of essential oil and plant extracts aqueous and ethanolic of Psidium cattleianum Sabine; the chemical composition of the essential oil of P. cattleianum; and the phytochemical screening of aqueous and ethanolic extracts of the same plant. Regarding the antimicrobial activity, the ethanolic extract exhibited moderate antimicrobial activity with respect to bacteria K. pneumoniae and S. epidermidis, whereas, regarding other microorganisms, it showed activity considered weak. The aqueous extract and the essential oil showed activity considered weak, although they inhibited the growth of microorganisms. About the antioxidant potential, the ethanolic and aqueous extracts exhibited a scavenging index exceeding 90%, while the essential oil didn´t show significant antioxidant activity. Regarding the phytochemical composition, the largest class of volatile compounds identified in the essential oil of P. cattleianum included the following terpenic hydrocarbons: α-copaene (22%); eucalyptol (15%), δ-cadinene (9.63%) and α-selinene (6.5%). The phytochemical screening of extracts showed the presence of tannins, flavonoids, and triterpenoids for aqueous and ethanolic extracts. The extracts and essential oils inhibit the growth of microrganisms and plant extracts showed significant antioxidant activity. Also, the phytochemical characterization of the essential oil showed the presence of compounds interest commercial, as well as extracts showed the presence of important classes and compounds with biological activities.Keywords: Psidium cattleianum, antimicrobial action, microdilution, GC-MS, antioxidant activity. Atividade antimicrobiana e antioxidante do óleo essencial e diferentes extratos vegetais de Psidium cattleianum Sabine ResumoOs objetivos do trabalho foram determinar: as atividades antimicrobiana e antioxidante do óleo essencial e dos extratos vegetais aquoso e etanólico de Psidium cattleianum Sabine; a composição química do óleo essencial P. cattleianum e a triagem fitoquímica dos extratos vegetais aquoso e etanólico da mesma planta. Quanto à atividade antimicrobiana, o extrato etanólico apresentou atividade antimicrobiana moderada frente as bactérias K. pneumonieae e S. epidermidis, enquanto frente aos demais micro-organismos apresentou atividade considerada fraca. O extrato aquoso e o óleo essencial apresentaram atividade considerada fraca, embora tenham inibido o crescimento dos micro-organismos. Em relação ao potencial antioxidante, os extratos etanólico e aquoso apresentaram índice de sequestro superior a 90%, enquanto o óleo essencial não apresentou atividade antioxidante significativa. Para a composição fitoquímica, a maior classe de compostos voláteis identificados no óleo essencial de P. cattleianum foram os hidrocarbonetos terpênicos, sendo eles: α-copaeno (22%), eucaliptol (15%), δ-cadineno (9,63%) e α-selineno (6,5%). Na triagem fitoquímica dos extratos verificou-se a presença de taninos, flavonóides e triterpenói...

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Section: Resultsmentioning

confidence: 99%

Antimicrobial and antioxidant activity of essential oil and different plant extracts of Psidium cattleianum Sabine

et al. 2016

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“…Thymol's main mode of action is believed to involve outer and inner membrane disruptions, as well as, binding to intracellular targets disrupting a variety of cellular functions (Walsh et al, 2003;Turina et al, 2006;Xu et al, 2008). Relating the resistance phenotype of microorganisms with the activity of phyto-constituents is conflict ridden.…”

Section: Discussionmentioning

confidence: 99%

Combined efficacy of thymol and silver nanoparticles against Staphylococcus aureus

Abdelhamid¹,

El‐Hosseiny²

2017

Afr. J. Microbiol. Res.

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Due to the looming spread of resistance to classical antimicrobial agents, innovative therapeutic methods are in dire need to combat the onslaught of resistant bacterial pathogens. This study examines the antimicrobial efficacy of a phytochemical and a metallic nanoparticle against the top Gram positive resistant pathogen. The potential synergy of these two agents was also evaluated. The antibacterial activity of thymol and silver nanoparticles were tested individually using disc diffusion technique. The extent of synergy of their combination was evaluated using the checkerboard assay. Twenty clinical isolates of Staphylococcus aureus characterized as methicillin resistant or methicillin sensitive Staphylococcus aureus were utilized and the extent of synergism was calculated from fractional inhibitory concentration indices. Thymol exhibited an antistaphylococcal activity regardless of whether the isolates were phenotypically resistant or sensitive to methicillin. Combining thymol with silver nanoparticles resulted in at least additive or synergistic effect for all the examined strains and methicillin resistant strains were inhibited in the combinatorial assays to a greater extent comparative to when silver nanoparticles or thymol were used singly.

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“…Our results are compatible with Hicham et al [51] who concluded that antifungal activity increased by the combination between clove oil and coconut oil. The lipophilic effect of the monoterpenes that found in essential oils give them the antimicrobial activity by disrupting microbial cytoplasmic membrane, then loss of impermeability for bigger ions and protons; it's function are compromised in barrier as well as the matrix of enzymes, and as an energy transducer if disturbance of membrane integrity occurs [50]. The combination result between plant oils and vinegar (Table 9) showed that vinegar doesn't increase the activity of clove oil at a same time appeared antagonism effect by decrease zone of inhibition when used vinegar with (clove oil with coconut oil) from 50mm into 22mm and (thyme oil) from 35 into 14mm.…”

Section: Activity Assay By Agar Diffusion Well Methodsmentioning

confidence: 99%

Activity of Some Disinfectants, Detergents and Essential Oils on Growth of the yeast Candida albicans

AL-Salihi

Jumaah

2017

MJS

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The study was conducted for estimating antifungal activity against Candida albicans of ten essential oil, garlic and onion juice, eight disinfectants and detergents by using agar diffusion well method. The results showed high activity of clove oil, onion juice 50%, thyme oil, hydrogen peroxide (H 2 O 2 ), lugol's iodine and detol for all the five concentration, sodium chloride (NaCl) and sodium carbonate (Na 2 CO 3 ) at 5%, while the effect of apple cider vinegar were at 60% and 80%. Sodium hypochlorite showed moderate activity at all concentration. The result of combination between clove oil and coconut oil led to synergistic effect while the combination between each of (1, 2, 3 % H 2 O 2 with each of apple cider vinegar and NaCl), (sodium chloride with apple cider vinegar) and (pumpkin oil with clove oil) lead to antagonism as well as the same results were reported when apple cider vinegar mixed with each of (thyme oil) and (clove oil with coconut oil). On the other hand, there is no synergistic or antagonistic effect of combination between 4-5% of H 2 O 2 with apple cider vinegar and NaCl solution to the growth of C. albicans. It was concluded that solitary use of compounds (clove oil, onion juice, thyme oil, H 2 O 2 , NaCl, lugol's iodine, detol, and apple cider vinegar) was associated with high antifungal response regarding C. albicans; efficacy was reduced when used in combination. In exception to above finding synergistic effect was identified when a combination between clove oil and coconut oil.

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Natural terpenes: Self-assembly and membrane partitioning

Cited by 247 publications

References 37 publications

Antimicrobial and antioxidant activity of essential oil and different plant extracts of Psidium cattleianum Sabine

Antimicrobial and antioxidant activity of essential oil and different plant extracts of Psidium cattleianum Sabine

Combined efficacy of thymol and silver nanoparticles against Staphylococcus aureus

Activity of Some Disinfectants, Detergents and Essential Oils on Growth of the yeast Candida albicans

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