Natural Schistosoma mansoni infection in Nectomys squamipes: histopathological and morphometric analysis in comparison to experimentally infected N. squamipes and C3H/He mice

Costa-Silva, Michele; Rodrigues-Silva, Rosângela; Hulstijn, Maarten; Neves, Renata Heisler; Panasco, Mônica de Souza; Lenzi, Henrique Leonel; Machado-Silva, José Roberto

doi:10.1590/s0074-02762002000900026

Cited by 21 publications

(14 citation statements)

References 45 publications

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“…In the present study, naturally infected animals showed an immune response characterized by the strong presence of macrophages in the formation of different developmental stages of granulomas. The same finding was reported by Costa-Silva et al (2002), who studied N. squamipes naturally infected by S. mansoni. According to those authors, histopathological changes -both qualitative and quantitative -were less marked in naturally infected animals than in the experimental groups, suggesting that the intensity of the response to infection depends on the host species, the S. mansoni strain, and the number of cercariae.…”

Section: Discussionsupporting

confidence: 87%

Biochemical and histological changes in liver ofNectomys squamipes naturally infected bySchistosoma mansoni

Neto

Alves

et al. 2013

Rev. Bras. Parasitol. Vet.

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The South American water rat Nectomys squamipes is a wild mammal reservoir of Schistosoma mansoni in Brazil. In the present study, wild rodents were collected in the field and categorized into two groups: infected and uninfected by S. mansoni. Blood was collected to analyze changes in the serum glucose level (mg/dL) and liver fragments were used to determine the hepatic glycogen content (mg of glucose/g tissue). The histological examination showed inflammatory granulomatous lesions in different phases of development in the liver of rodents naturally infected with S. mansoni, in some cases with total or partial occlusion of the vascular lumen. Early lesions were characterized by the presence of inflammatory infiltrate around morphologically intact recently deposited eggs. Despite the significance of these histological lesions, the biochemical changes differed in extent. N. squamipes naturally infected by S. mansoni showed no variation in hepatic glycogen reserves. These findings were accompanied by a significant increase in plasma glucose contents, probably as a consequence of amino acids deamination, which are degraded, resulting in the formation of intermediates used as precursors for the glucose formation, without compromising the reserves of liver glycogen. In the wild, naturally infected N. squamipes can maintain S. mansoni infections without undergoing alterations in its carbohydrate metabolism, which minimizes the deleterious effects of S. mansoni.Keywords: Biochemical alterations, rodents, wild reservoirs, alternative model. ResumoNectomys squamipes é um mamífero silvestre reservatório de Schistosoma mansoni no Brasil. No presente estudo, os roedores silvestres, colhidos no campo, foram classificados em dois grupos: infectado e não infectado por S. mansoni. O sangue foi colhido para análise da alteração no nível de glicose sérico (mg/dL) e fragmentos de fígado foram usados para determinar o conteúdo de glicogênio hepático (mg de glicose/g tecido). A análise histológica demonstrou lesões granulomatosas em diferentes fases de desenvolvimento no tecido hepático dos roedores naturalmente infectados com S. mansoni, localizados principalmente na região periportal, com total ou parcial oclusão do lúmen vascular. As lesões foram caracterizadas por presença de infiltrado inflamatório ao redor de ovos morfologicamente intactos recentemente depositados. Apesar da grande significância das lesões histológicas, as alterações bioquímicas não diferiram no mesmo

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Section: Discussionsupporting

confidence: 87%

Biochemical and histological changes in liver ofNectomys squamipes naturally infected bySchistosoma mansoni

Neto

Alves

et al. 2013

Rev. Bras. Parasitol. Vet.

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“…Reactions were classified as the pre-granulomatous stage (weakly reactive or nonreactive and exudative stages) or the granulomatous stage (exudative-productive, productive and involutional granulomas). The area, perimeter and major and minor diameter of individual granulomas were measured by computed image analysis (Image Pro-Plus Media Cybernetics, US), as described previously (Costa-Silva et al 2002).…”

Section: Methodsmentioning

confidence: 99%

The outcome of acute schistosomiasis infection in adult mice with postnatal exposure to maternal malnutrition

Corrêa

Lisboa

Oliveira

et al. 2011

Mem. Inst. Oswaldo Cruz

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“…granulomas was assessed and the granulomas were classified into three types (fibrous, cellular, and fibrocellular) according to the predominant component (Costa-Silva et al 2002). …”

Section: Article In Pressmentioning

confidence: 99%

Congenital exposure to Schistosoma mansoni infection: Impact on the future immune response and the disease outcome

et al. 2010

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Natural Schistosoma mansoni infection in Nectomys squamipes: histopathological and morphometric analysis in comparison to experimentally infected N. squamipes and C3H/He mice

Abstract: Histopathologic and morphometric (area, perimeter, major and minor diameters)

Cited by 21 publications

References 45 publications

Biochemical and histological changes in liver ofNectomys squamipes naturally infected bySchistosoma mansoni

Biochemical and histological changes in liver ofNectomys squamipes naturally infected bySchistosoma mansoni

The outcome of acute schistosomiasis infection in adult mice with postnatal exposure to maternal malnutrition

Congenital exposure to Schistosoma mansoni infection: Impact on the future immune response and the disease outcome

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