Congenital exposure to Schistosoma mansoni infection: Impact on the future immune response and the disease outcome

Othman, Ahmad A.; Shoheib, Zeinab Salah; Saied, Eman M.; Soliman, Rabie

doi:10.1016/j.imbio.2009.04.004

Cited by 17 publications

(21 citation statements)

References 57 publications

(61 reference statements)

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“…Chronic morbidity during infection with S. mansoni develops as a result of schistosome worms and eggs lodging in the liver and causing granulomatous inflammation that ends with fibrosis [33]. This result is in supported by the worm and ova counts observed in S. mansoni infected mice (Table 3).…”

Section: Resultsmentioning

confidence: 63%

Potency of detergents in enhancing Schistosoma mansoni tegumental antigens

Hamed

2011

J Infect Dev Ctries

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Introduction: Vaccine strategies represent an essential component for the future control of schistosomiasis. This work aimed to evaluate the role of detergents for potentiating the effect of Schistosoma mansoni tegumental antigens (TA) against challenge infection. Methodology: Two detergents; Triton X-100 (TX-100) and sodium dodecyl sulfate (SDS), were selected for extraction of tegumental proteins. Mice were vaccinated with two doses of each preparation (100 μg protein) at time intervals 15 days before infection. Evaluation was performed by estimating particular metabolic pathways, including the Krebs cycle (via succinate dehydrogenase); glycolysis (lactate dehydrogenase); gluconeogenesis (glucose-6-phosphatase); hydrolytic enzymes (acid phosphatase); and nucleic acid catabolic enzymes (5`-nucleotidase). Serum protein profiles, worm burden, ova counts, spleen and relative liver weights were also investigated. The work was extended to study the histopathological picture of the liver including granuloma count, and total infection area. Vaccinated post-challenged mice showed amelioration of the selected biochemical parameters and reduction in worm and ova count (P ≤ 0.0001) as well as improvement in the histological features of the liver. Results: Triton X-100 potentiated the protective effect of S. mansoni tegumental antigen and extracted effective proteins better than SDS, while TA alone recorded the lowest level of protection. Conclusion: TX-100 will be more efficient for future studies in molecular identification of novel candidate tegumental proteins.

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Section: Resultsmentioning

confidence: 63%

Potency of detergents in enhancing Schistosoma mansoni tegumental antigens

Hamed

2011

J Infect Dev Ctries

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“…39,41 In several animal models, littermates born to mothers with schistosomiasis show limited infection and reduced pathologic changes when exposed for the first time. 2,5,11,17,42 Furthermore, the effector phase components 43,44 required for IgE-mediated immunity are already functional. 42 Therefore, SEA-specific IgE may also play an important role in the immune system of human newborns.…”

Section: Discussionmentioning

confidence: 99%

“…However, there is increasing evidence of in utero sensitization as a result of maternal helminth infections. [2][3][4][5][6][7] The question of how infections and/or microbial products in the mother might affect the development of the fetal immune system is of particular interest because it may explain disease patterns later in life.…”

Section: Introductionmentioning

confidence: 99%

“…Some studies have suggested that prenatal priming might be beneficial and lead to protection against infections or to reduced pathologic changes, [2][3][4][5][6]8 and other studies have suggested that prenatal exposure might be detrimental and lead to development of allergic responses 3,9 or to unresponsiveness 3,8,10,11 and therefore inadequate reactivity of the immune system to infections or immunizations. 8,12,13 It has also been suggested that prenatal sensitization rather than exposure to helminths during childhood is important in determining the initial immune response elicited by natural infection.…”

Section: Introductionmentioning

confidence: 99%

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Association of In Utero Sensitization to Schistosoma haematobium with Enhanced Cord Blood IgE and Increased Frequencies of CD5– B Cells in African Newborns

Seydel

Petelski²,

Dam³

et al. 2012

The American Journal of Tropical Medicine and Hygiene

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Abstract. This study investigated in utero priming as a consequence of maternal parasitic infections. Cord blood plasma samples of 63 African newborns were assessed by enzyme-linked immunosorbent assay for their content of total and schistosome-specific or filaria-specific IgE and IgG4. The frequencies of lymphocyte phenotypes in cord blood were also determined by using flow cytometry, and were compared with those of European newborns. We found significantly increased schistosome soluble egg antigen (SEA)-specific IgE in cord plasma of those born to mothers with schistosome infections and correlations between fetal and maternal SEA-specific and filaria antigen-specific IgE. These data are evidence for in utero priming of the fetal immune system to maternal helminth infections. Furthermore, we show significantly enhanced percentages of CD5-B cells in African newborns cord blood compared with Europeans, which is consistent with earlier maturation of the African fetal immune system.

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“…In mice, infection with S. mansoni during pregnancy and breastfeeding modulates the immunity against homologous antigen in postnatal infection leading to a reduction in granuloma size and number in the offspring. These findings were associated with early sensitization through transfer of circulating schistosomal antigens and maternal parasite-specific antibodies via the placenta and breast milk [69,76,77].…”

Section: Schistosomiasismentioning

confidence: 99%