Natural rubber latex allergy

Kahn, Steven L.; Podjasek, Joshua O.; Dimitropoulos, Vassilios; Brown, C. W.

doi:10.1016/j.disamonth.2015.11.002

Cited by 39 publications

(45 citation statements)

References 88 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Latex allergy and anaphylaxis to contrast media are more common in patients with a history of atopy. They are also more common in patients with an allergy to fruits, especially banana, chestnut and avocado .…”

Section: Factors Contributing To Adverse Drug Reactionssupporting

confidence: 78%

“…Healthcare professionals and patients undergoing multiple procedures, such as those with spina bifida, are at increased risk of latex allergy. This also applies to workers who have an occupational exposure to latex . However, unlike those high‐risk patients where environmental sensitisation from a young age is the primary mechanism, there may be a genetic component predisposing healthcare workers in addition to prior exposure .…”

Section: Factors Contributing To Adverse Drug Reactionsmentioning

confidence: 99%

See 1 more Smart Citation

Adverse drug reactions

Patton¹,

Borshoff

2018

Anaesthesia

View full text Add to dashboard Cite

SummaryAdverse drug reactions are a cause of significant morbidity and mortality to patients and a source of financial burden to the healthcare system. Of the wide spectrum of adverse drug reactions, the most concerning to the anaesthetist remain anaphylaxis and malignant hyperthermia. Although the incidence of anaphylaxis under anaesthesia is difficult to ascertain, it occurs commonly enough that most anaesthetists will manage at least one case in their career. The wide range of drugs given in the peri-operative period and the variable presentation in the anaesthetised patient can delay diagnosis and treatment, and adversely affect outcome. Furthermore, despite improvements in testing, causative drugs can still be difficult to identify, as adverse reactions may be mediated by mechanisms other than IgE activation. With an increase in the reporting of anaphylaxis to newer anaesthetic drugs such as sugammadex, combined with change over the recent decades in the most likely causative peri-operative agents, it is imperative anaesthetists remain up to date on recent developments. In addition, they should be vigilant to patient characteristics, including pharmacogenetic variations that may predispose to adverse drug reactions, in order to help minimise risks of a reaction. The severity of adverse drug reactions to peri-operative drugs means morbidity and mortality remain high.

show abstract

Section: Factors Contributing To Adverse Drug Reactionssupporting

confidence: 78%

Section: Factors Contributing To Adverse Drug Reactionsmentioning

confidence: 99%

Adverse drug reactions

Patton¹,

Borshoff

2018

Anaesthesia

View full text Add to dashboard Cite

show abstract

“…Si bien la alergia a látex ha decaído en Estados Unidos en los últimos años, de 150,000 a 1'000,000 de trabajadores de la salud, cerca de 15 millones de personas en el mundo aún sufren alergia al látex. 5 La alergia al látex es un problema de salud pública en pacientes de riesgo. Aunque en la actualidad la alergia al látex se reconoce como poco frecuente 1 a 2% de la población en general, aún existen grupos de riesgo bien diferenciados.…”

Section: Introductionunclassified

Prevalencia de sensibilización al látex mediante prueba cutánea (prick test) en pacientes con malformaciones genitourinarias con más de tres intervenciones quirúrgicas

Macías-Robles

Morán-Mendoza

2016

RAM

View full text Add to dashboard Cite

154www.nietoeditores.com.mx R Re ev vi is st ta a M Mé éx xi ic co o artículo original Prevalencia de sensibilización al látex mediante prueba cutánea (prick test) en pacientes con malformaciones genitourinarias con más de tres intervenciones quirúrgicas Resumen INTRODUCCIÓN: la alergia al látex tiene alta prevalencia en grupos de riesgo conocidos, especialmente en pacientes con espina bífida, malformaciones urinarias y ortopédicas con múltiples cirugías. En Mé-xico no se cuenta con suficientes estudios que reporten la prevalencia y factores de riesgo asociados.OBJETIVO: determinar la prevalencia de sensibilización al látex mediante prueba de prick con extracto de látex en pacientes con malformaciones genitourinarias y más de tres cirugías en la Unidad Médica de Alta Especialidad de Pediatría del Centro Médico Nacional de Occidente, así como los factores asociados.RESULTADOS: la prevalencia encontrada fue de 30.7% y los factores de riesgo asociados: atopia personal (p=0.047), antecedente de reacción previa con productos con látex (p=0.003), específicamente con globos (p=0.000) y guantes (p=0.002). No hubo asociación entre el número de cirugías e intervenciones quirúrgicas a edades tempranas, tampoco con concentraciones elevadas de IgE sérica total. Tuvieron reacción cruzada a frutas-látex 25% de los pacientes, los alimentos asociados fueron: aguacate, papaya, fresa y kiwi. CONCLUSIÓN: la prevalencia de sensibilización al látex es alta en los grupos de riesgo, sobre todo con antecedente de atopia, por lo que es importante que el personal de salud identifique a estos pacientes a fin de implementar oportunamente las medidas de prevención primaria y secundaria; evitar efectos severos potencialmente mortales, como la anafilaxia, para disminuir la morbilidad y la mortalidad y los costos sanitarios.PALABRAS CLAVE: sensibilización a látex, alergia, prueba de PRICK, atopia, cirugías. Rev Alerg Méx 2016 abr-jun;63(2):154-162.

show abstract

“…Irritant contact dermatitis is caused by a nonimmunological inflammation of the skin [5, 6]. Typical symptoms are dry, erythematous, thickened, scaling and fissuring skin, typically accompanied by an itching or burning sensation [5-7].…”

Section: Introductionmentioning

confidence: 99%

“…Type IV allergy is caused by a T-cell-mediated reaction to the chemicals used in the manufacturing process of NRL and not the NRL itself [6]. Typical type IV symptoms are itchy, eczematous rashes, usually confined to the areas of exposed skin, developing within 24–48 h of exposure [5-7].…”

Section: Introductionmentioning

confidence: 99%

The Clinical Relevance of Natural Rubber Latex-Specific IgE in Patients Sensitized to Timothy Grass Pollen

Brandi

Poulsen

Garvey

2019

Int Arch Allergy Immunol

View full text Add to dashboard Cite

Background: In pollen-allergic patients, cross-reacting allergens including cross-reactive carbohydrate determinants (CCDs) and profilins may result in positive natural rubber latex (NRL)-specific IgE (sIgE) antibody tests but the relationship between this sensitization and clinical NRL type 1 allergy is poorly described. Objective: The aims of this study were to determine the frequency and clinical relevance of NRL sIgE in grass pollen-sensitized individuals and to investigate which NRL allergen components these individuals were sensitized to. Methods: A total of 383 grass-sensitized patients answered questions about NRL allergy symptoms and their stored sera from previous investigations were analyzed for NRL sIgE. Patients with NRL sIgE (n = 32) underwent further investigations comprising medical history, skin prick test with NRL and inhalational allergens, and an additional blood sample. The additional blood samples were analyzed for total IgE and sIgE against NRL, timothy grass, birch, rHev b 1, 3, 5, 6.01, 6.02, 8, 9, 11, rPhl p 12, and MUXF3, which was used as a marker of CCD sensitization. Results: Overall, 9.4% of all grass pollen-sensitized individuals showed IgE sensitization to NRL but only 1.6% had a confirmed type I NRL allergy. CCD and Hev b 8 explained the clinically irrelevant NRL IgE sensitization in 65% of the cases. We found a highly significant correlation between NRL profilin (Hev b 8) sensitization and grass profilin (Phl p 12) sensitization (p < 0.0001). Conclusions: Data from this study support the hypothesis that in patients with grass pollen sensitization, Hev b 8 mono-sensitization has little or no clinical relevance and is caused by cross sensitization from grass profilin (Phl p 12).

show abstract

Natural rubber latex allergy

Cited by 39 publications

References 88 publications

Adverse drug reactions

Adverse drug reactions

Prevalencia de sensibilización al látex mediante prueba cutánea (prick test) en pacientes con malformaciones genitourinarias con más de tres intervenciones quirúrgicas

The Clinical Relevance of Natural Rubber Latex-Specific IgE in Patients Sensitized to Timothy Grass Pollen

Contact Info

Product

Resources

About