Natural resistance-associated macrophage protein 1 gene polymorphisms in rheumatoid arthritis

Yen, Jeng‐Hsien; Lin, Chia Hui; Tsai, Wen Chun; Ou, Tsan‐Teng; Wu, Cheng Chin; Hu, Chaur Jong; Liu, Hong Wen

doi:10.1016/j.imlet.2005.07.008

Cited by 16 publications

(15 citation statements)

References 36 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…1 Although the exact SNPs underlying such differential responsiveness are under investigation, one genetic variation involved in the control of immune inflammatory reactions between AIRmin and AIRmax strains is well known and involves the gene SLC11A1 (NRAMP1). 28,37 Interestingly, SNPs in SLC11A1 have been associated with the resistance/ susceptibility to human RA development, [38][39][40] but unfortunately no data regarding SLC11A1 association with human PD is available in the literature. Accordingly, with the shared genetic susceptibility hypothesis, preliminary data from our group 41 point to a significant higher frequency of the 3/3 genotype of SLC11A1 rs34448891 SNP (earlier associated to RA) 38 in chronic PD patients.…”

Section: Discussionmentioning

confidence: 99%

Periodontitis and arthritis interaction in mice involves a shared hyper-inflammatory genotype and functional immunological interferences

Trombone¹,

Claudino²,

Colavite³

et al. 2010

Genes Immun

View full text Add to dashboard Cite

Periodontitis (PD) and rheumatoid arthritis (RA) have been found to be clinically associated and to share the chronic nature of the inflammatory reaction associated with bone resorption activity. However, the mechanisms underlying such association are unknown. Therefore, we examined the basis of Actinobacillus actinomycetemcomitans-and Porphyromonas gingivalis-induced PD and pristane-induced arthritis (PIA) interaction in mice. Higher severity PD in the genetically inflammation prone acute inflammatory reactivity maximum (AIRmax) mice strain was associated with higher levels of TNF-a, IL-1b, IL-17, matrix metalloproteinase (MMP)-13, and RANKL, whereas PD/PIA co-induction resulted in even higher levels of IL-1b, IFN-g, IL-17, RANKL, and MMP-13 levels. Conversely, PD/PIA co-induction in AIRmin strain did not alter the course of both pathologies. PIA/PD co-induction resulted in altered expression of T-cell subsets transcription factors expression, with T-bet and RORg levels being upregulated, whereas GATA-3 levels were unaltered. Interestingly, PIA induction resulted in alveolar bone loss, such response being highly dependent on the presence of commensal oral bacteria. No differences were found in PIA severity parameters by PD co-induction. Our results show that the interaction between experimental PD and arthritis in mice involves a shared hyper-inflammatory genotype and functional interferences in innate and adaptive immune responses.

show abstract

Section: Discussionmentioning

confidence: 99%

Periodontitis and arthritis interaction in mice involves a shared hyper-inflammatory genotype and functional immunological interferences

Trombone¹,

Claudino²,

Colavite³

et al. 2010

Genes Immun

View full text Add to dashboard Cite

show abstract

“…We found no significant association between INT4 polymorphism and TB, but there was a significant association between INT4 polymorphism and RA. This contrasts with the studies reporting no association between INT4 polymorphism and RA from countries like Taiwan (Yen et al ., 2006), Canada (Singal et al ., 2000) and Korea (Yang et al ., 2000). A link between INT4 polymorphism and TB was reported from West Africa (Bellamy et al ., 1998) but studies from other countries failed to show this association (Ryu et al ., 2000; Puzyrev et al ., 2002; Soborg et al ., 2002; Zhang et al ., 2005; Vejbaesya et al ., 2007).…”

Section: Discussionmentioning

confidence: 99%

NRAMP1 (SLC11A1) gene polymorphisms that correlate with autoimmune versus infectious disease susceptibility in tuberculosis and rheumatoid arthritis

Ateş

Dalyan

Müsellim³

et al. 2009

Int J Immunogenetics

View full text Add to dashboard Cite

NRAMP1 gene has multiple pleiotropic effects on macrophage activation pathways. These pleiotropic effects may increase resistance to infections such as tuberculosis (TB), but may also lead to susceptibility of autoimmune diseases such as rheumatoid arthritis (RA). It has been hypothesized that allele 3 would be associated with autoimmune diseases, whereas allele 2 would be associated with infectious diseases, and genetic factors that enhanced survival in the epidemics of TB might have led to susceptibility for the development of RA. We analysed four NRAMP1 gene polymorphisms including 5' promoter (GT)(n) (rs34448891), INT4 (469 + 14G/C) (rs3731865), 3'UTR (1729 + 55del4) (rs17235416) and D543N (codon 543, Asp to Asn) (rs17235409) in 112 patients with TB, 98 patients with RA, 80 healthy controls for TB and 122 healthy controls for RA using ARMS-PCR and PCR-RFLP. We found a significant association between INT4 and RA (P = 0.004, odds ratio: 2.06, 95% CI: 1.24-3.41), but no significant differences between 5' promoter, D543N, 3'UTR polymorphisms and RA. There were no associations between NRAMP1 gene polymorphisms and TB. Similarly, no significant differences were observed between NRAMP1 polymorphisms and rheumatoid factor positivity and erosive disease in RA and localization of TB. INT4 polymorphism may be associated with RA in Turkish patients.

show abstract

“…Nine single nucleotide polymorphisms (SNPs) were selected from the HapMap database (http:// hapmap.ncbi.nlm.nih.gov) and the remaining variants were selected from the dbSNP (http://www.ncbi.nlm.nih.gov/projects/ SNP), the JSNP database (http://snp.ims.u-tokyo.ac.jp), or the published literature including 4 frequently reported polymorphisms: rs17235416 in the 3= UTR, rs17235409 (D543N), rs3731865 in INT4, and rs34448891 (5=(GT)n) [19,31,32].…”

Section: Selection Of Polymorphic Loci For Genotypic Analysismentioning

confidence: 99%

Association of SLC11A1 (NRAMP1) polymorphisms with pulmonary Mycobacterium avium complex infection

et al. 2012

View full text Add to dashboard Cite

Natural resistance-associated macrophage protein 1 gene polymorphisms in rheumatoid arthritis

Cited by 16 publications

References 36 publications

Periodontitis and arthritis interaction in mice involves a shared hyper-inflammatory genotype and functional immunological interferences

Periodontitis and arthritis interaction in mice involves a shared hyper-inflammatory genotype and functional immunological interferences

NRAMP1 (SLC11A1) gene polymorphisms that correlate with autoimmune versus infectious disease susceptibility in tuberculosis and rheumatoid arthritis

Association of SLC11A1 (NRAMP1) polymorphisms with pulmonary Mycobacterium avium complex infection

Contact Info

Product

Resources

About